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| Other Sizes |
| Targets |
(2S,3S)-2-amino-3-methylpentan-1-ol does not have a specific biological target itself but serves as a chiral building block for organic synthesis. Its structural similarity to L-isoleucine allows it to be used as a probe for studying BCAA metabolism. The compound may interact with enzymes involved in amino acid metabolism, such as aminotransferases and dehydrogenases, but these interactions are not therapeutic targets. Its primary utility is in chemical synthesis as a chiral reagent.
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| ln Vitro |
In vitro activity of this compound is characterized by its use as a chiral building block in organic synthesis. The compound's reactivity is determined by its amino and hydroxyl functional groups, which can be selectively modified. It can be used in the synthesis of chiral ligands, pharmaceuticals, and other complex molecules. The compound's stereochemistry makes it valuable for the preparation of enantiomerically pure compounds. Systematic in vitro pharmacological profiling is not performed.
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| ln Vivo |
In vivo biological activity of this compound is limited to its potential use as a probe for studying BCAA metabolism. As it is structurally similar to L-isoleucine, it may be taken up by cells and metabolized by enzymes in the BCAA pathway. However, the compound is not used as a therapeutic agent, and its biological effects are not the focus of its applications. Its primary use is in chemical synthesis.
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| Enzyme Assay |
Non-cellular experiments for this compound typically involve its use as a chiral building block in organic synthesis. A typical protocol includes using the compound in the synthesis of amides, esters, or other derivatives by reacting the amino or hydroxyl groups with appropriate reagents. The compound can also be used as a chiral auxiliary or ligand in asymmetric synthesis. Analytical methods such as TLC, HPLC, and NMR are used to monitor reactions and confirm product identity.
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| Cell Assay |
Cell-based assays are not typically performed with this compound, as it is primarily used as a chiral building block in organic synthesis. However, its structural similarity to L-isoleucine may allow it to be used in studies of amino acid transport and metabolism in cell culture models. The compound is not tested in cell culture models for pharmacological activity.
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| Animal Protocol |
In vivo animal studies are not performed with this compound in a therapeutic context. Its applications are confined to chemical synthesis and research. No efficacy or safety studies in animal models are available for therapeutic use. The compound is not intended for human or veterinary use as a drug. Researchers should consult safety data sheets for handling and disposal guidelines.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of this compound are not extensively characterized. Its molecular weight is 117.19 g/mol, and it is very soluble in water. The compound has a melting point of 36-39°C and a boiling point of 97°C at 14 mmHg. No detailed pharmacokinetic data are available.
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| Toxicity/Toxicokinetics |
Toxicological data for this compound are limited. It should be handled with appropriate safety precautions, as it may be irritating to skin, eyes, and respiratory tract. The compound is stable under recommended storage conditions. No carcinogenic or reproductive toxicity data are available. Researchers should consult the safety data sheet for specific hazard information and handling guidelines. The compound is not intended for human use.
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| Additional Infomation |
(2S,3S)-2-amino-3-methylpentan-1-ol is a chiral amino alcohol used as a building block in organic synthesis. Its CAS number is 24629-25-2. The compound is available with a purity of ≥97% from various suppliers. It is used in the synthesis of chiral ligands, pharmaceuticals, and other complex molecules. The compound is not approved for therapeutic use but is an important tool for asymmetric synthesis. It should be stored in a cool, dry place.
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| Molecular Formula |
C6H15NO
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|---|---|
| Molecular Weight |
117.19
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| Exact Mass |
117.115
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| CAS # |
24629-25-2
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| PubChem CID |
2724027
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| Appearance |
<36°C Solid Powder,>39°C Liquid
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| Density |
0.9±0.1 g/cm3
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| Boiling Point |
196.9±0.0 °C at 760 mmHg
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| Melting Point |
36-39 °C(lit.)
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| Flash Point |
100.6±0.0 °C
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| Vapour Pressure |
0.1±0.8 mmHg at 25°C
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| Index of Refraction |
1.450
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| LogP |
0.45
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
8
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| Complexity |
56.5
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| Defined Atom Stereocenter Count |
2
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| SMILES |
O([H])C([H])([H])[C@]([H])([C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])N([H])[H]
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| InChi Key |
VTQHAQXFSHDMHT-NTSWFWBYSA-N
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| InChi Code |
InChI=1S/C6H15NO/c1-3-5(2)6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t5-,6+/m0/s1
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| Chemical Name |
(2S,3S)-2-amino-3-methylpentan-1-ol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.5332 mL | 42.6658 mL | 85.3315 mL | |
| 5 mM | 1.7066 mL | 8.5332 mL | 17.0663 mL | |
| 10 mM | 0.8533 mL | 4.2666 mL | 8.5332 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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