| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Dextrosil KA does not have a biological target as it is an industrial chemical used in polymer modification. Its primary function is to introduce cationic quaternary ammonium groups onto cellulose, starch, and other polymers, improving their properties for various applications. The compound's cationic nature allows it to bind to negatively charged surfaces and improve the performance of materials in papermaking, textile finishing, and water treatment.
|
|---|---|
| ln Vitro |
In vitro biological activity is not assessed for this compound, as it is an industrial chemical rather than a therapeutic agent. Its reactivity is characterized by its ability to react with hydroxyl groups on polymers under alkaline conditions, forming ether bonds. The compound's quaternary ammonium group provides permanent positive charge to the modified materials. Systematic in vitro pharmacological profiling is not performed.
|
| ln Vivo |
In vivo biological activity is not applicable for this compound, as it is an industrial chemical used in polymer modification rather than a therapeutic agent. Its applications are confined to industrial processes. No in vivo efficacy or pharmacological studies in animal models are available. The compound is not designed for systemic administration.
|
| Enzyme Assay |
Non-cellular experiments for this compound typically involve its use in the modification of polymers. A typical protocol includes dissolving the compound in water and adding it to a cellulose or starch slurry under alkaline conditions. The reaction proceeds at elevated temperatures, and the degree of substitution is determined by titration or elemental analysis. The modified polymer's properties, such as charge density and viscosity, are characterized.
|
| Cell Assay |
Cell-based assays are not applicable for this compound, as it is an industrial chemical rather than a pharmacological agent. It is not tested in cell culture models for biological activity. The compound is used exclusively in industrial applications. Researchers should handle this compound with appropriate safety precautions.
|
| Animal Protocol |
In vivo animal studies are not performed with this compound in a therapeutic context. Its applications are confined to industrial processes. No efficacy or safety studies in animal models are available for therapeutic use. The compound is not intended for human or veterinary use as a drug. Researchers should consult safety data sheets for handling and disposal guidelines.
|
| ADME/Pharmacokinetics |
Pharmacokinetic properties are not characterized for this compound, as it is an industrial chemical rather than a therapeutic agent. Its molecular weight is 188.09 g/mol, and it is supplied as an aqueous solution. The compound is highly soluble in water. No data on absorption, distribution, metabolism, or excretion are available.
|
| Toxicity/Toxicokinetics |
Toxicological data for Dextrosil KA indicate that it is corrosive and can cause severe skin and eye irritation. The compound decomposes on heating, producing toxic and flammable vapors. It should be handled with appropriate personal protective equipment. The compound is toxic to aquatic organisms. No carcinogenic or reproductive toxicity data are available. Researchers should consult the safety data sheet for specific hazard information.
|
| Additional Infomation |
Structure in the first source
Dextrosil KA is a quaternary ammonium compound used in polymer modification. Its CAS number is 3327-22-8. The compound is typically supplied as a 65% aqueous solution. It is used in the production of cationic starches and other modified polymers for papermaking, textiles, and water treatment. The compound is not approved for therapeutic use. It should be stored in a cool, well-ventilated area away from heat and incompatible materials. |
| Molecular Formula |
C6H15CL2NO
|
|---|---|
| Molecular Weight |
188.10
|
| Exact Mass |
187.053
|
| CAS # |
3327-22-8
|
| PubChem CID |
18732
|
| Appearance |
Typically exists as solid at room temperature
|
| Density |
1.154 g/mL at 25 °C
|
| Boiling Point |
190-209ºC
|
| Melting Point |
191-193°C
|
| Flash Point |
>230 °F
|
| Index of Refraction |
n20/D 1.4541
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
3
|
| Heavy Atom Count |
10
|
| Complexity |
79.6
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
C[N+](C)(C)CC(O)CCl.[Cl-]
|
| InChi Key |
CSPHGSFZFWKVDL-UHFFFAOYSA-M
|
| InChi Code |
InChI=1S/C6H15ClNO.ClH/c1-8(2,3)5-6(9)4-7;/h6,9H,4-5H2,1-3H3;1H/q+1;/p-1
|
| Chemical Name |
(3-chloro-2-hydroxypropyl)-trimethylazanium;chloride
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.3163 mL | 26.5816 mL | 53.1632 mL | |
| 5 mM | 1.0633 mL | 5.3163 mL | 10.6326 mL | |
| 10 mM | 0.5316 mL | 2.6582 mL | 5.3163 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
