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| Other Sizes |
| Targets |
5-Methylpyridin-2(1H)-one does not have a well-defined biological target, as it is primarily used as a chemical reagent and synthetic intermediate. The pyridone scaffold is found in various bioactive molecules, and this compound may serve as a building block for the synthesis of compounds that target specific receptors or enzymes. However, the compound itself is not a therapeutic agent, and its biological targets are not characterized. Its utility lies in its role as a versatile synthetic intermediate.
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| ln Vitro |
In vitro activity is not assessed for this compound, as it is a synthetic intermediate rather than a therapeutic agent. Its reactivity is characterized by its ability to undergo various chemical transformations, including N-alkylation, electrophilic aromatic substitution, and metal-catalyzed cross-coupling reactions. The compound's pyridone core makes it a valuable building block for the synthesis of pharmaceuticals and other bioactive molecules. Systematic in vitro pharmacological profiling is not performed.
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| ln Vivo |
In vivo biological activity is not applicable for this compound, as it is a chemical reagent used in synthesis rather than a therapeutic agent. Its applications are confined to chemical synthesis and laboratory research. No in vivo efficacy or pharmacological studies in animal models are available. The compound is not designed for systemic administration and should be handled as a chemical reagent with appropriate safety precautions.
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| Enzyme Assay |
Non-cellular experiments for this compound typically involve its use as a starting material in organic synthesis. A typical protocol includes using the compound in N-alkylation reactions with alkyl halides to form N-substituted pyridones, or in electrophilic aromatic substitution to introduce additional substituents. The compound can also be used in metal-catalyzed cross-coupling reactions after conversion to the corresponding halide. Analytical methods such as TLC, HPLC, and NMR are used to monitor reactions.
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| Cell Assay |
Cell-based assays are not applicable for this compound, as it is a synthetic intermediate rather than a pharmacological agent. It is not tested in cell culture models for biological activity. The compound is used exclusively in chemical synthesis. Researchers should handle this compound with appropriate safety precautions.
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| Animal Protocol |
In vivo animal studies are not performed with this compound in a therapeutic context. Its applications are confined to chemical synthesis and laboratory research. No efficacy or safety studies in animal models are available. The compound is not intended for human or veterinary use. Researchers should consult safety data sheets for handling and disposal guidelines.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties are not characterized for this compound, as it is a synthetic intermediate rather than a therapeutic agent. Its molecular weight is 109.13 g/mol, and it has a melting point of 183-187°C. The compound is soluble in organic solvents and slightly soluble in water. No data on absorption, distribution, metabolism, or excretion are available.
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| Toxicity/Toxicokinetics |
Toxicological data for this compound are limited. It should be handled with appropriate safety precautions, as it may be irritating to skin, eyes, and respiratory tract. The compound is stable under recommended storage conditions. No carcinogenic or reproductive toxicity data are available. Researchers should consult the safety data sheet for specific hazard information and handling guidelines. The compound is not intended for human use.
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| Additional Infomation |
5-Methyl-2-pyridinol is a type of methylpyridine compound.
5-Methylpyridin-2(1H)-one is a pyridine derivative used as a biochemical reagent and synthetic intermediate. Its CAS number is 1003-68-5. The compound is available with a purity of ≥98% from various suppliers. It is widely used in biochemical experiments and drug synthesis research. The compound is not approved for therapeutic use but is an important building block for pharmaceutical development. It should be stored in a cool, dry place. |
| Molecular Formula |
C6H7NO
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|---|---|
| Molecular Weight |
109.13
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| Exact Mass |
109.052
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| CAS # |
1003-68-5
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| PubChem CID |
70482
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| Appearance |
Off-white to yellow solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
304.2±15.0 °C at 760 mmHg
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| Melting Point |
183-187 °C(lit.)
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| Flash Point |
170.6±5.3 °C
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| Vapour Pressure |
0.0±0.6 mmHg at 25°C
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| Index of Refraction |
1.500
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| LogP |
0.01
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
8
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| Complexity |
167
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CC1=CNC(=O)C=C1
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| InChi Key |
SOHMZGMHXUQHGE-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H7NO/c1-5-2-3-6(8)7-4-5/h2-4H,1H3,(H,7,8)
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| Chemical Name |
5-methyl-1H-pyridin-2-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 9.1634 mL | 45.8169 mL | 91.6338 mL | |
| 5 mM | 1.8327 mL | 9.1634 mL | 18.3268 mL | |
| 10 mM | 0.9163 mL | 4.5817 mL | 9.1634 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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