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| Other Sizes |
| Targets |
Dansyl hydrazine does not have a defined biological target as a therapeutic agent. It is a fluorescent labeling reagent used in analytical chemistry. The compound reacts with carbonyl-containing compounds to form fluorescent derivatives that can be detected by chromatography or fluorescence spectroscopy. Its utility lies in its chemical properties rather than biological activity.
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| ln Vitro |
Specific in vitro activity data for Dansyl hydrazine as a pharmacological agent are not documented in the literature. It is a fluorescent labeling reagent used in analytical chemistry. The compound is not characterized for direct biological activities such as enzyme inhibition or receptor modulation. Its primary applications are in the detection and quantification of carbonyl-containing compounds in biological and environmental samples.
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| ln Vivo |
Dansyl hydrazine is not used for in vivo pharmacological activity assessment as a drug compound. It is a fluorescent labeling reagent used in analytical chemistry. The compound is not intended to be administered to animals for pharmacological studies. Its use in biological research is as a reagent for the detection of carbonyl compounds in samples.
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| Enzyme Assay |
Dansyl hydrazine is not typically used in enzyme/receptor binding assays as a test compound. Its primary application is as a fluorometric labeling reagent for carbonyl compounds. When used in research, it is employed to derivatize aldehydes and ketones for detection by HPLC or other chromatographic methods. Standard analytical protocols are employed for its use.
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| Cell Assay |
Dansyl hydrazine is not used in cell-based assays as a test compound. Its primary application is as a fluorescent labeling reagent for carbonyl compounds in analytical chemistry. The compound may be used to detect carbonyl-containing metabolites in cell culture media or lysates, but it is not characterized as a pharmacological agent for direct cellular effects.
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| Animal Protocol |
Dansyl hydrazine is not used in animal studies as a pharmacological agent. Its primary application is as a fluorescent labeling reagent in analytical chemistry. The compound may be used to detect carbonyl compounds in biological samples from animal studies, but it is not administered as a test compound for efficacy evaluations. Its use is limited to analytical detection.
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| ADME/Pharmacokinetics |
Dansyl hydrazine has a molecular weight of 265.33 g/mol and a molecular formula of C₁₂H₁₅N₃O₂S. It appears as a light yellow to brown solid powder with a melting point of 126-130°C. The compound is slightly soluble in alcohol. It is used as a fluorometric reagent for carbonyl compounds and is intended for research and analytical use only.
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| Toxicity/Toxicokinetics |
Dansyl hydrazine is intended for research and analytical use only and is not approved for human therapeutic applications. As a fluorescent labeling reagent, comprehensive toxicological data are not extensively documented in the publicly accessible literature. Standard safety precautions should be observed when handling this compound, including the use of appropriate personal protective equipment. The compound should be handled in well-ventilated areas with proper waste disposal procedures.
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| Additional Infomation |
Dansyl hydrazine (Dansylhydrazine) (CAS#: 33008-06-9) has a molecular formula of C₁₂H₁₅N₃O₂S and a molecular weight of 265.33 g/mol. It is a UV-excited fluorescent dye used for derivatizing ketones and aldehydes for chromatographic analysis. The compound is widely used as a fluorometric reagent for carbonyl compounds. This compound is not a drug and is a fluorescent labeling reagent.
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| Molecular Formula |
C12H15N3O2S
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|---|---|
| Molecular Weight |
265.33
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| Exact Mass |
265.088
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| CAS # |
33008-06-9
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| PubChem CID |
94442
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| Appearance |
Light yellow to brown solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
450.8±37.0 °C at 760 mmHg
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| Melting Point |
126-130 °C(lit.)
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| Flash Point |
226.4±26.5 °C
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| Vapour Pressure |
0.0±1.1 mmHg at 25°C
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| Index of Refraction |
1.660
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| LogP |
1.54
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
18
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| Complexity |
377
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| Defined Atom Stereocenter Count |
0
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| SMILES |
NNS(C1=CC=CC2=C(C=CC=C21)N(C)C)(=O)=O
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| InChi Key |
KPQYDVAFRDWIBW-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C12H15N3O2S/c1-15(2)11-7-3-6-10-9(11)5-4-8-12(10)18(16,17)14-13/h3-8,14H,13H2,1-2H3
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| Chemical Name |
5-(dimethylamino)naphthalene-1-sulfonohydrazide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7689 mL | 18.8445 mL | 37.6889 mL | |
| 5 mM | 0.7538 mL | 3.7689 mL | 7.5378 mL | |
| 10 mM | 0.3769 mL | 1.8844 mL | 3.7689 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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