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| Other Sizes |
| Targets |
Sodium stearate does not have a defined biological target as a therapeutic agent. It is an excipient and a surfactant used in pharmaceutical formulations. The compound is not intended to exert pharmacological effects. Its primary applications are as a gelling agent, emulsifier, and lubricant in various products. It is generally regarded as safe for use in food and pharmaceutical applications when used in accordance with good manufacturing practices.
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| ln Vitro |
Specific in vitro activity data for Sodium stearate as a pharmacological agent are not documented in the literature. It is used as an excipient and surfactant rather than as a drug substance. The compound is not characterized for direct biological activities such as enzyme inhibition or receptor modulation. Its effects in biological systems are primarily related to its physical properties as a surfactant and emulsifier.
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| ln Vivo |
Sodium stearate is not used for in vivo pharmacological activity assessment as a drug compound. It is an excipient and a surfactant used in pharmaceutical formulations. The compound is not intended to be administered as a therapeutic agent. Its presence in pharmaceutical products is as an inactive ingredient. Its safety and tolerability have been established through its use in approved products.
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| Enzyme Assay |
Sodium stearate is not typically used in enzyme/receptor binding assays as a test compound. Its primary applications are as an excipient and surfactant. When used in research, it may be employed in studies of surfactant properties or as a component of formulations. Standard chemical and pharmaceutical protocols are employed for its use, rather than biochemical assay procedures.
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| Cell Assay |
Sodium stearate is not used in cell-based assays as a test compound. Its primary applications are as an excipient and surfactant. The compound is not characterized for direct cellular effects. It may be used in studies of cell membrane interactions or as a component of cell culture media, but it is not a pharmacological agent. Its effects on cells are primarily related to its surfactant properties.
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| Animal Protocol |
Sodium stearate is not used in animal studies as a pharmacological agent. Its primary applications are as an excipient and surfactant. The compound may be present in animal studies as a component of formulations or diets. Its safety has been established through its use in approved products. It is not administered as a test compound for efficacy evaluations.
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| ADME/Pharmacokinetics |
Sodium stearate has a molecular weight of 306.46 g/mol and a molecular formula of C₁₈H₃₅NaO₂. It is a white, odorless solid with a melting point of 270°C and a density of 1.07 g/cm³. The compound is used as a surfactant, emulsifier, thickening agent, and lubricant. It is typically stored under standard laboratory conditions.
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| Toxicity/Toxicokinetics |
Toxicity Summary
The CIR expert panel concluded that, at the current methods of use and concentrations described in the safety assessment, the following ingredients are safe when formulated as non-irritating and non-allergenic. This conclusion may be based on a quantitative risk assessment (QRA)... Sodium stearate... Safe for use in cosmetics, subject to specific conditions. Toxicity Data Acute oral toxicity (LD50): 4640 mg/kg [rat]. Acute dermal toxicity (LD50): >5000 mg/kg [rabbit]. Sodium stearate is generally recognized as safe (GRAS) for use in food and pharmaceutical applications. It is non-irritating to the skin and is one of the least allergy-causing sodium salts of fatty acids. As an excipient, it has been evaluated for safety in pharmaceutical products. Standard safety precautions should be observed when handling this compound, including the use of appropriate personal protective equipment. |
| Additional Infomation |
Sodium octadecanoate is an organic sodium salt composed of equal amounts of sodium ions and stearate ions. It is a detergent. It contains octadecanoate ions.
Sodium stearate (Stearic acid sodium salt) (CAS#: 822-16-2) has a molecular formula of C₁₈H₃₅NaO₂ and a molecular weight of 306.46 g/mol. It is a white, odorless solid used as a surfactant, emulsifier, thickening agent, and lubricant in cosmetics, pharmaceuticals, and food additives. In pharmaceuticals, it functions as a lubricant in tablet manufacturing. This compound is not a drug and is an excipient. |
| Molecular Formula |
C18H35NAO2
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|---|---|
| Molecular Weight |
306.46
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| Exact Mass |
306.253
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| CAS # |
822-16-2
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| Related CAS # |
Stearate-d35 sodium;1219794-97-4
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| PubChem CID |
2724691
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| Appearance |
WHITE POWDER
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| Density |
1.103 g/cm3
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| Boiling Point |
359.4ºC at 760 mmHg
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| Melting Point |
245 - 255ºC
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| Flash Point |
162.4ºC
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| LogP |
4.997
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
16
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| Heavy Atom Count |
21
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| Complexity |
207
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| Defined Atom Stereocenter Count |
0
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| SMILES |
[Na].O=C(CCCCCCCCCCCCCCCCC)O
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| InChi Key |
RYYKJJJTJZKILX-UHFFFAOYSA-M
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| InChi Code |
InChI=1S/C18H36O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2-17H2,1H3,(H,19,20);/q;+1/p-1
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| Chemical Name |
sodium;octadecanoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2631 mL | 16.3153 mL | 32.6307 mL | |
| 5 mM | 0.6526 mL | 3.2631 mL | 6.5261 mL | |
| 10 mM | 0.3263 mL | 1.6315 mL | 3.2631 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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