| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| 1g |
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| 5g | |||
| Other Sizes |
| Targets |
MEGA-8 does not have a defined biological target as a therapeutic agent. It is a non-ionic detergent used for the solubilization of membrane proteins in biochemical research. The compound is not intended to exert pharmacological effects. Its utility lies in its ability to solubilize proteins without denaturing them, making it valuable for protein purification and structural studies.
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|---|---|
| ln Vitro |
Specific in vitro activity data for MEGA-8 as a pharmacological agent are not documented in the literature. It is used as a research reagent rather than as a drug substance. The compound is not characterized for direct biological activities such as enzyme inhibition or receptor modulation. Its effects in biological systems are related to its detergent properties and its ability to solubilize membrane proteins.
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| ln Vivo |
MEGA-8 is not used for in vivo pharmacological activity assessment as a drug compound. Its primary applications are as a non-ionic detergent for protein solubilization in biochemical research. The compound is not intended to be administered to animals for pharmacological studies. Its use is limited to in vitro applications in protein biochemistry.
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| Enzyme Assay |
MEGA-8 is not typically used in enzyme/receptor binding assays as a test compound. Its primary application is as a detergent for protein solubilization. When used in research, it is employed in protocols for membrane protein extraction and purification. Standard biochemical protocols are employed for its use, including its incorporation into lysis buffers and solubilization solutions.
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| Cell Assay |
MEGA-8 is used in cell-based assays as a detergent for cell lysis and protein extraction. Cells are treated with buffers containing MEGA-8 to solubilize membrane proteins for downstream analysis. The compound is not characterized as a pharmacological agent for direct cellular effects. Its use is limited to sample preparation for protein biochemistry studies.
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| Animal Protocol |
MEGA-8 is not used in animal studies as a pharmacological agent. Its primary applications are as a non-ionic detergent for protein solubilization in biochemical research. The compound is not intended to be administered to animals for efficacy evaluations. Its use is limited to in vitro applications in protein biochemistry.
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| ADME/Pharmacokinetics |
MEGA-8 has a molecular formula of C₁₅H₃₁NO₆ and a molecular weight of 321.41 g/mol. It is also known as N-Octanoyl-N-methylglucamine. The compound is a non-ionic detergent used for the solubilization of membrane proteins. It is typically stored under standard laboratory conditions and is intended for research use only.
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| Toxicity/Toxicokinetics |
MEGA-8 is intended for research use only and is not approved for human therapeutic applications. As a research reagent, comprehensive toxicological data are not extensively documented in the publicly accessible literature. Standard safety precautions should be observed when handling this compound, including the use of appropriate personal protective equipment. The compound should be handled in well-ventilated areas with proper waste disposal procedures.
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| Additional Infomation |
The structure given in the first document
MEGA-8 (N-Octanoyl-N-methylglucamine) (CAS#: 85316-98-9) is a non-ionic detergent used for the solubilization of membrane proteins in biochemical research. It is a mild detergent suitable for protein purification and structural studies. This compound is not a drug and is a research reagent. |
| Molecular Formula |
C15H31NO6
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|---|---|
| Molecular Weight |
321.41
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| Exact Mass |
321.215
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| CAS # |
85316-98-9
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| PubChem CID |
160091
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| Appearance |
White to off-white solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
581.8±50.0 °C at 760 mmHg
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| Flash Point |
305.6±30.1 °C
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| Vapour Pressure |
0.0±3.7 mmHg at 25°C
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| Index of Refraction |
1.526
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| LogP |
-0.28
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| Hydrogen Bond Donor Count |
5
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
12
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| Heavy Atom Count |
22
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| Complexity |
302
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| Defined Atom Stereocenter Count |
4
|
| SMILES |
[C@@H](O)([C@@H](O)CN(C)C(=O)CCCCCCC)[C@H](O)[C@H](O)CO
|
| InChi Key |
SBWGZAXBCCNRTM-CTHBEMJXSA-N
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| InChi Code |
InChI=1S/C15H31NO6/c1-3-4-5-6-7-8-13(20)16(2)9-11(18)14(21)15(22)12(19)10-17/h11-12,14-15,17-19,21-22H,3-10H2,1-2H3/t11-,12+,14+,15+/m0/s1
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| Chemical Name |
N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]octanamide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1113 mL | 15.5565 mL | 31.1129 mL | |
| 5 mM | 0.6223 mL | 3.1113 mL | 6.2226 mL | |
| 10 mM | 0.3111 mL | 1.5556 mL | 3.1113 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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