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| Other Sizes |
| Targets |
Pyren-1-ylmethanamine hydrochloride does not have a defined biological target as a therapeutic agent. It is a fluorescent compound used as a probe and label in biochemical research. The compound is not intended to exert pharmacological effects. Its utility lies in its fluorescent properties, which enable the detection and visualization of biomolecules in various research applications, including fluorescence microscopy and flow cytometry.
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| ln Vitro |
For life science-related study, pyren-1-ylmethanamine hydrochloride is a biochemical reagent that can be utilized as an organic substance or biological material.
Specific in vitro activity data for Pyren-1-ylmethanamine hydrochloride as a pharmacological agent are not documented in the literature, as it is primarily used as a fluorescent probe. The compound is not characterized for direct biological activities such as enzyme inhibition, receptor modulation, or antimicrobial effects. Its utility lies in its fluorescent properties for labeling and detection applications. |
| ln Vivo |
Pyren-1-ylmethanamine hydrochloride is not used for in vivo pharmacological activity assessment as a drug compound. Its primary applications are as a fluorescent probe and label in biochemical research. The compound is not intended to be administered to animals for pharmacological studies. Its use is limited to in vitro applications as a fluorescent label.
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| Enzyme Assay |
Pyren-1-ylmethanamine hydrochloride is not used in enzyme/receptor binding assays as a test compound. Its primary applications are as a fluorescent probe for labeling biomolecules. When used in research, it is employed to label proteins, nucleic acids, or other biomolecules for detection by fluorescence. Standard biochemical protocols for fluorescent labeling are employed for its use, rather than enzyme binding assays.
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| Cell Assay |
Pyren-1-ylmethanamine hydrochloride is used in cell-based assays as a fluorescent probe for labeling and imaging cellular components. Cells are treated with the compound or its conjugates to visualize specific cellular structures or biomolecules using fluorescence microscopy or flow cytometry. Standard cell culture conditions (37°C, 5% CO₂) with appropriate media are employed. The compound itself is not characterized as a pharmacological agent.
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| Animal Protocol |
Pyren-1-ylmethanamine hydrochloride is not used in animal studies as a pharmacological agent. Its primary applications are as a fluorescent probe for in vitro research. The compound may be used in animal studies as a tracer or label for imaging applications, but it is not administered as a test compound for efficacy evaluations. Its use is limited to research applications.
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| ADME/Pharmacokinetics |
Pyren-1-ylmethanamine hydrochloride has a molecular weight of 267.75 g/mol and a molecular formula of C₁₇H₁₄ClN. It is a white to light yellow crystalline solid. The compound is a pyrene derivative with strong fluorescence properties. It is used as a fluorescent probe and label in biochemical research. It is typically stored under standard laboratory conditions, protected from light, as pyrene derivatives can be photosensitive.
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| Toxicity/Toxicokinetics |
Pyren-1-ylmethanamine hydrochloride is intended for research use only and is not approved for human therapeutic applications. As a fluorescent probe, comprehensive toxicological data are not extensively documented in the publicly accessible literature. Standard safety precautions should be observed when handling this compound, including the use of appropriate personal protective equipment. The compound should be handled in well-ventilated areas with proper waste disposal procedures.
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| Additional Infomation |
Pyren-1-ylmethanamine hydrochloride (1-Pyrenemethylamine hydrochloride) (CAS#: 93324-65-3) is a fluorescent compound used as a probe and label in biochemical and biophysical research. It is a pyrene derivative with strong fluorescence properties used for labeling biomolecules. This compound is not a drug and has not undergone clinical trials.
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| Molecular Formula |
C17H14CLN
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| Molecular Weight |
267.75
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| Exact Mass |
267.081
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| CAS # |
93324-65-3
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| PubChem CID |
11601427
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| Appearance |
Light brown to brown solid powder
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| Boiling Point |
437.9ºC at 760 mmHg
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| Melting Point |
258ºC (dec.)(lit.)
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| Flash Point |
223.5ºC
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| LogP |
5.545
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
19
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| Complexity |
313
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)CN.Cl
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| InChi Key |
RGNMXKKNDSHTFD-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C17H13N.ClH/c18-10-14-7-6-13-5-4-11-2-1-3-12-8-9-15(14)17(13)16(11)12;/h1-9H,10,18H2;1H
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| Chemical Name |
pyren-1-ylmethanamine;hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7348 mL | 18.6741 mL | 37.3483 mL | |
| 5 mM | 0.7470 mL | 3.7348 mL | 7.4697 mL | |
| 10 mM | 0.3735 mL | 1.8674 mL | 3.7348 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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