| Size | Price | Stock | Qty |
|---|---|---|---|
| 50g |
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| Other Sizes |
| ln Vitro |
A biochemical reagent called nonan-1-ol can be utilized in life science research as an organic substance or biological material.
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|---|---|
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Skin absorption is low; in vitro studies show that the dermal flux of 1-nonanol in human skin (epidermis) is 0.003 mg/cm²/hr. Metabolism/Metabolites Like other primary alcohols, nonanol undergoes two main reactions in vivo. First, it is oxidized to form carboxylic acid derivatives, and then it directly binds to glucuronic acid. The extent to which nonanol directly binds to glucuronic acid has been reported to be 4.1%. Compared to methylpentanol and 2-ethylbutanol, which form ester glucuronides, the oxidation of nonanol is almost uninhibited. |
| Toxicity/Toxicokinetics |
Toxicity Data
LC50 (mice) = 5,500 mg/m³/2h Non-human toxicity values Mouse inhalation LC50: 5500 mg/m²/hour Rat oral LD50: 3.56 g/kg Rabbit dermal 24-hour LD50: 5.66 ml/kg Mouse intraperitoneal injection LD50: 0.8 g/kg /Nonanol/ For more complete non-human toxicity data for 1-nonanol (10 in total), please visit the HSDB record page. |
| Additional Infomation |
Nonanol is a colorless liquid with a rose or fruity odor, floats on water, and has a freezing point of -5°C (23°F). (US Coast Guard, 1999)
Non-1-ol is a nonane derivative with a hydroxyl group substituted at the 1-position. It has been isolated from the volatile oils of plants such as barley. Nonanol can be used as a plant metabolite, volatile oil component, flavoring agent, and antifungal agent. It is a nonanol and also a primary alcohol. Non-1-ol has been reported in Francisella tularensis, Humulus lupulus, and several other organisms with relevant data. Mechanism of Action...Medium-chain alcohols (pentanol to octanol) cause the channel current to fluctuate between fully open and fully closed states, causing the channel opening to occur in the form of a burst of pulses, accompanied by brief gaps...The number of gaps in the burst depends on the concentration of the alcohol, while the duration of the gaps is independent of concentration but increases with increasing alcohol chain length, up to octanol. Nonanol and decanol shortened the average duration of pulse train open time but did not increase the number of brief off intervals within the pulse train. Beyond decanol, the ability of n-alcohols to affect channel function began to decline. Saturated undecyl alcohol solution (0.07 mM) reduced the average open time by 33 ± 17%, while saturated dodecanol solution had no significant effect. All n-alcohols from pentanol to undecyl alcohol reduced the current integral per pulse. The IC50 values are as follows: hexanol, 0.53 ± 0.14 mM; heptanol, 0.097 ± 0.02 mM; octanol, 0.04 mM; nonanol, 0.16 ± 0.035 mM… The calculated blocking rate constant (k+B) for pentanol to nonanol ranges from 2.8 to 5.7 × 10⁶ /M/s… The equilibrium dissociation constant (KD) (KD = kB/k+B), calculated from the blocking rate constant and the dissociation rate constant, decreases with increasing chain length, from 8 mM for pentanol to 0.15 mM for octanol. The calculated standard free energy of each methylene group adsorbed to the adsorption site is approximately -3.3 kJ/mol. |
| Molecular Formula |
C9H20O
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|---|---|
| Molecular Weight |
144.26
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| Exact Mass |
144.151
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| CAS # |
143-08-8
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| Related CAS # |
Nonan-1-ol-d19;349553-86-2;Nonan-1-ol-d4;33975-46-1
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| PubChem CID |
8914
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| Appearance |
Colorless to yellowish liquid
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| Density |
0.827 g/mL at 25 °C(lit.)
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| Boiling Point |
215 °C(lit.)
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| Melting Point |
−8-−6 °C(lit.)
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| Flash Point |
208 °F
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| Vapour Pressure |
13 mm Hg ( 104 °C)
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| Index of Refraction |
n20/D 1.433(lit.)
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| LogP |
2.729
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
10
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| Complexity |
52.7
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
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| InChi Key |
ZWRUINPWMLAQRD-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C9H20O/c1-2-3-4-5-6-7-8-9-10/h10H,2-9H2,1H3
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| Chemical Name |
nonan-1-ol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.9319 mL | 34.6596 mL | 69.3193 mL | |
| 5 mM | 1.3864 mL | 6.9319 mL | 13.8639 mL | |
| 10 mM | 0.6932 mL | 3.4660 mL | 6.9319 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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