| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
1,2-Dilaurin does not have a defined pharmacological target as it is a biochemical reagent and internal standard. As a diacylglycerol, it may interact with enzymes involved in lipid metabolism such as lipases and diacylglycerol kinases. The compound is used as an internal standard for the quantification of diglycerides and as a substrate for measuring lipase activity in membrane studies.
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| ln Vitro |
No specific in vitro pharmacological activity data are available for 1,2-dilaurin as a drug candidate. In research applications, the compound is used as an internal standard for the quantification of diacylglycerol in biological samples. Monomolecular films containing 1,2-dilauroyl-rac-glycerol have been used as substrates to measure surface pressure and the effects of membrane-associated lipases on pancreatic lipase activity.
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| ln Vivo |
No specific in vivo pharmacological activity data have been documented for 1,2-dilaurin as a therapeutic agent. The compound is used as an internal standard in analytical studies of lipid metabolism. It has been used to quantify diacylglycerol in rat desheathed sciatic nerve. The compound is not developed as a therapeutic agent and is not administered for pharmacological evaluation.
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| Enzyme Assay |
For non-cellular assays, 1,2-dilaurin is characterized by standard analytical techniques including HPLC, LC-MS, and NMR to confirm identity and purity. The compound is used as an internal standard for the quantification of diacylglycerols in biological samples. Typical protocols involve extracting lipids from samples, adding 1,2-dilaurin as an internal standard, and analyzing by LC-MS or HPLC. The compound is also used in lipase activity assays with monomolecular films.
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| Cell Assay |
For in vitro cell-based studies, 1,2-dilaurin is not typically used as a direct test compound. It may be used in lipid metabolism studies as a reference standard or as a component of lipid mixtures for cell culture experiments. If used in cell-based assays, the compound is typically dissolved in organic solvents such as ethanol or DMSO and diluted in cell culture medium. Appropriate controls should be included in the experimental design.
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| Animal Protocol |
For in vivo animal studies, 1,2-dilaurin has been used as an internal standard for the quantification of diacylglycerol in rat desheathed sciatic nerve. The compound is extracted from tissue samples along with endogenous lipids for analytical quantification. It is not administered as a therapeutic agent. Standard animal handling and tissue collection protocols should be followed.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of 1,2-dilaurin are not characterized as it is a biochemical reagent. The compound has a molecular weight of 456.70 and molecular formula C27H52O5. Storage: -20°C, sealed storage, away from moisture. In solvent: stable at -20°C for 1 month (sealed storage, away from moisture). The compound is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions.
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| Toxicity/Toxicokinetics |
Toxicity Summary
The expert panel concluded that glyceryl dilaurate is safe as a cosmetic ingredient under the usage methods and concentrations described in this safety assessment, provided that its 1,2-diester content is insufficient to induce epidermal hyperplasia. It can be safely used in cosmetics under specific conditions. 1,2-Dilaurin is for research use only and not for human consumption. Standard laboratory safety practices should be followed when handling this chemical. Appropriate personal protective equipment including gloves and safety glasses should be worn. Specific LD50 values and detailed toxicological profiles have not been extensively reported. The compound should be handled with care as with all laboratory chemicals. |
| References |
[1]. Zhu X, et al. 1,2-diacylglycerol content and its arachidonyl-containing molecular species are reduced in sciatic nerve from streptozotocin-induced diabetic rats. J Neurochem. 1990 Sep;55(3):1087-90.
[2]. Wieloch T, et al. Porcine pancreatic procolipase and its trypsin-activated form: lipid binding and lipase activation on monomolecular films. FEBS Lett. 1981 Jun 15;128(2):217-20. |
| Additional Infomation |
1,2-Dilaurin is safe. The RN indicated here refers to compounds without specified isomers.
1,2-Dilaurin (CAS 17598-94-6) is also known as (rac)-1,2-didodecanoylglycerol, dilaurin, diglyceride, didodecanoin, and 1,2-dilaurin (C12:0). It is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions. The compound is commonly used in the food and cosmetic industries and as an internal standard for lipid quantification. No clinical or therapeutic applications exist. |
| Molecular Formula |
C27H52O5
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|---|---|
| Molecular Weight |
456.70
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| Exact Mass |
456.381
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| CAS # |
17598-94-6
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| PubChem CID |
33979
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| Appearance |
White to off-white solid powder
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| Density |
0.953g/cm3
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| Boiling Point |
531ºC at 760mmHg
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| Flash Point |
158ºC
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| LogP |
7.275
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
26
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| Heavy Atom Count |
32
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| Complexity |
424
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CCCCCCCCCCCC(OCC(OC(CCCCCCCCCCC)=O)CO)=O
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| InChi Key |
OQQOAWVKVDAJOI-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C27H52O5/c1-3-5-7-9-11-13-15-17-19-21-26(29)31-24-25(23-28)32-27(30)22-20-18-16-14-12-10-8-6-4-2/h25,28H,3-24H2,1-2H3
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| Chemical Name |
(2-dodecanoyloxy-3-hydroxypropyl) dodecanoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 50 mg/mL (109.48 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1896 mL | 10.9481 mL | 21.8962 mL | |
| 5 mM | 0.4379 mL | 2.1896 mL | 4.3792 mL | |
| 10 mM | 0.2190 mL | 1.0948 mL | 2.1896 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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