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| Other Sizes |
| ADME/Pharmacokinetics |
Metabolism / Metabolites
Carbon disulfide and its major metabolite, 2-thiothiazolidin-4-carboxylic acid, are common metabolites of almost all dithiocarbamates. Significantly elevated concentrations of these compounds in urine have been observed under various exposure conditions and for different dithiocarbamates. Zinc can enter the body via the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is regulated by the zinc carrier protein CRIP. Zinc can also bind to metallothioneins, thus helping to prevent excessive zinc absorption. Zinc is widely distributed in all tissues and tissue fluids, with higher concentrations in the liver, gastrointestinal tract, kidneys, skin, lungs, brain, heart, and pancreas. In the blood, zinc binds to carbonic anhydrase in erythrocytes and also to albumin, β2-macroglobulin, and amino acids in plasma. Albumin- and amino acid-bound zinc can diffuse across tissue membranes. Zinc is excreted in urine and feces. (L49) |
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| Toxicity/Toxicokinetics |
Toxicity Summary
Anemia is caused by excessive zinc absorption inhibiting the absorption of copper and iron, likely through competitive binding with intestinal mucosal cells. An imbalance in the binding levels of copper and zinc with copper-zinc superoxide dismutase is associated with amyotrophic lateral sclerosis (ALS). Gastric acid dissolves metallic zinc to form corrosive zinc chloride, which damages the gastric mucosa. Metal fume fever is thought to be an immune response following zinc inhalation. (L48, L49, A49) Toxicity Data LD50: 142 mg/kg (oral, mouse) (T14) Non-human Toxicity Values Rabbit oral LD50: 400 mg/kg body weight Rat oral LD50: 3340 mg/kg Mouse oral LD50: 142 mg/kg |
| Additional Infomation |
Zinc diethyldithiocarbamate is a dithiocarbamate, specifically the zinc salt of diethyldithiocarbamate. It is an accelerator and activator for natural rubber and also has antifungal properties. It is a dithiocarbamate and a zinc molecular entity. It contains a diethyldithiocarbamate ion and a zinc ion (Zn²⁺). It is functionally related to diethyldithiocarbamate. Zinc dithiocarbamate, also known as zinc diethyldithiocarbamate salt, is a known copper and zinc chelating agent. It is also a skin sensitizer and allergen. Sensitivity to zinc dithiocarbamate can be identified through clinical patch testing. Zinc diethyldithiocarbamate is a standardized chemical allergen. The physiological effects of zinc diethyldithiocarbamate are achieved through increased histamine release and cell-mediated immune responses. Zinc diethyldithiocarbamate is chemically classified as an allergen. Zinc diethyldithiocarbamate is a zinc compound. Zinc is a metallic element with atomic number 30. Its most common form in nature is sphalerite. While excessive zinc is harmful, small amounts are essential for life because it is a cofactor for over 300 enzymes and is present in just as many transcription factors (L48, L49). It is a chelating agent used to remove toxic metals from tissues in humans and laboratory animals. It is the major metabolite of disulfiram. Drug Indications Disulfiram is approved for use in allergic skin patch testing, an auxiliary diagnostic test for allergic contact dermatitis (ACD) in individuals aged 6 years and older. Mechanism of Action Carbamates, when used alone, have a weak activation of estrogen- or progesterone-responsive reporter genes in breast and endometrial cancer cells. All carbamates reduce estradiol- or progesterone-induced reporter gene activity in breast and endometrial cancer cells. In whole-cell competitive binding assays, carbamates have limited ability to displace radiolabeled estrogen or progesterone from estrogen or progesterone receptors.
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| Molecular Formula |
C10H20N2S4ZN
|
|---|---|
| Molecular Weight |
361.92
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| Exact Mass |
359.98
|
| CAS # |
14324-55-1
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| PubChem CID |
26633
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| Appearance |
White powder
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| Density |
1,48 g/cm3
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| Boiling Point |
176.4ºC at 760 mmHg
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| Melting Point |
178-181 °C(lit.)
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| Flash Point |
60.5ºC
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| Vapour Pressure |
1.1mmHg at 25°C
|
| LogP |
2.317
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
4
|
| Heavy Atom Count |
17
|
| Complexity |
73
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
[Zn+2].[S-]C(N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=S.[S-]C(N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=S
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| InChi Key |
RKQOSDAEEGPRER-UHFFFAOYSA-L
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| InChi Code |
InChI=1S/2C5H11NS2.Zn/c2*1-3-6(4-2)5(7)8;/h2*3-4H2,1-2H3,(H,7,8);/q;;+2/p-2
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| Chemical Name |
zinc;N,N-diethylcarbamodithioate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7630 mL | 13.8152 mL | 27.6304 mL | |
| 5 mM | 0.5526 mL | 2.7630 mL | 5.5261 mL | |
| 10 mM | 0.2763 mL | 1.3815 mL | 2.7630 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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