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| Other Sizes |
| Targets |
Tetrabutylammonium tetrahydroborate does not have a defined pharmacological target as it is a chemical reagent. Its primary function is as a reducing agent and catalyst in organic synthesis. The compound is a strong reducing agent used in the synthesis of hyperbranched polyglycerol and other organic compounds. It reacts with trifluoroacetic acid to form hydrogen borohydride. Its applications are limited to chemical synthesis and research laboratories.
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| ln Vitro |
A biochemical reagent called tetrabutylammonium tetrahydroborate can be utilized in life science research as an organic compound or biological material.
No specific in vitro pharmacological activity data are available for tetrabutylammonium tetrahydroborate as it is a chemical reagent. In research settings, the compound is used as a biochemical reagent for life science research. Its activity is assessed in terms of reducing power, selectivity, and synthetic utility rather than direct biological activity. The compound is used for the selective reduction of aldehydes, ketones, and imines under mild conditions. |
| ln Vivo |
No specific in vivo pharmacological activity data have been documented for tetrabutylammonium tetrahydroborate as it is not a therapeutic agent. The compound is used exclusively as a chemical reagent and reducing agent. It is not administered to animals for pharmacological evaluation. Its applications are limited to organic synthesis and chemical analysis laboratories.
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| Enzyme Assay |
For non-cellular assays, tetrabutylammonium tetrahydroborate is characterized by standard analytical techniques including NMR, HPLC, and titration to confirm identity and purity. The compound can be evaluated as a reducing agent in various organic reactions. Typical protocols involve dissolving the compound in appropriate organic solvents and testing its ability to reduce substrates such as esters, aldehydes, and ketones. Purity is typically ≥95% to ≥98%. The compound has a molecular weight of 257.31 and molecular formula C16H40BN.
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| Cell Assay |
Tetrabutylammonium tetrahydroborate is not used in cell-based assays as it is a chemical reagent. The compound is intended for synthetic chemistry applications. If handled in a biological laboratory context, appropriate safety precautions should be taken due to the reducing properties and potential reactivity. The compound should be stored in a cool, dry place protected from moisture.
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| Animal Protocol |
Tetrabutylammonium tetrahydroborate is not used in animal studies as it is a chemical reagent. The compound is handled in chemistry laboratories with appropriate personal protective equipment. Storage: keep in a cool, dry place protected from moisture. The compound should be stored in a tightly sealed container. Standard handling procedures for reducing agents should be followed.
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| ADME/Pharmacokinetics |
Tetrabutylammonium tetrahydroborate has a molecular weight of 257.31 and molecular formula C16H40BN. It has an EINECS number of 251-658-2 and MDL number MFCD00012035. Storage: keep in a cool, dry place protected from moisture. The compound is stable under recommended storage conditions. Solubility: soluble in organic solvents due to the lipophilic tetrabutylammonium cation.
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| Toxicity/Toxicokinetics |
Tetrabutylammonium tetrahydroborate is for research use only and not for human consumption. Standard laboratory safety practices should be followed when handling this chemical. The compound is a reducing agent and should be handled with care. Appropriate personal protective equipment including gloves and safety glasses should be worn. Specific LD50 values and detailed toxicological profiles have not been extensively reported.
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| Additional Infomation |
Structure in the first source
Tetrabutylammonium tetrahydroborate (CAS 33725-74-5) is also known as tetrabutylammonium borohydride and 1-butanaminium, N,N,N-tributyl-, tetrahydroborate(1-). It has an EINECS number of 251-658-2 and MDL number MFCD00012035. The compound is used as a strong reducing agent in organic synthesis, for the synthesis of hyperbranched polyglycerol, and in phase-transfer catalysis. No clinical trials or therapeutic approvals exist. |
| Molecular Formula |
C16H40BN
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|---|---|
| Molecular Weight |
257.31
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| Exact Mass |
257.325
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| CAS # |
33725-74-5
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| PubChem CID |
169536
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| Appearance |
White to off-white solid powder
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| Melting Point |
124-128 °C(lit.)
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| Flash Point |
140ºC ( 284.00 °F)
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| LogP |
3.819
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
12
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| Heavy Atom Count |
18
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| Complexity |
116
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CCCC[N+](CCCC)(CCCC)CCCC.[B-]
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| InChi Key |
GMBOFJFPOCGSOI-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H36N.BH4/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;/h5-16H2,1-4H3;1H4/q+1;-1
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| Chemical Name |
boranuide;tetrabutylazanium
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.8864 mL | 19.4318 mL | 38.8636 mL | |
| 5 mM | 0.7773 mL | 3.8864 mL | 7.7727 mL | |
| 10 mM | 0.3886 mL | 1.9432 mL | 3.8864 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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