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| Targets |
Sulfonated castor oil does not have a defined pharmacological target as it is a surfactant and industrial chemical. The compound is used as an anionic surfactant due to its amphiphilic nature, combining hydrophilic sulfonate and hydroxyl groups with a hydrophobic alkyl chain. It functions as a wetting agent, dispersing agent, levelling agent, and detergent in various applications including textiles, paints, inks, and metalworking oils.
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| ln Vitro |
No specific in vitro pharmacological activity data are available for sulfonated castor oil as it is a surfactant and industrial chemical. In research settings, the compound is used as a biochemical reagent for biomedical research. Its activity is assessed in terms of surface activity, wetting ability, emulsifying properties, and dispersing efficiency rather than direct biological activity. The compound is used as an oil agent for fiber fabrics and dyeing auxiliary.
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| ln Vivo |
No specific in vivo pharmacological activity data have been documented for sulfonated castor oil as it is not a therapeutic agent. The compound is used in industrial applications and as a research reagent. It is not administered to animals for pharmacological evaluation. Its applications are limited to industrial processes and laboratory research including textiles, cosmetics, and pesticide formulation.
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| Enzyme Assay |
For non-cellular assays, sulfonated castor oil is characterized by standard analytical techniques including HPLC, FTIR, and surface tension measurements. The compound can be evaluated for its emulsifying properties, wetting ability, and surface activity. Typical protocols involve preparing serial dilutions of the compound in aqueous buffer and measuring surface tension using a tensiometer. The compound has a water solubility of 1g/L at 25°C and a LogP of 1.4 at 25°C. Purity: typically 75% organically combined sulphate.
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| Cell Assay |
For in vitro cell-based studies, sulfonated castor oil is not typically used as a direct test compound. The compound is intended for industrial and biochemical research applications. If handled in a biological laboratory context, appropriate safety precautions should be taken due to the surfactant properties. Storage: 2-8°C. The compound should be stored in a sealed container away from moisture and incompatible materials.
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| Animal Protocol |
For in vivo animal studies, sulfonated castor oil is not typically administered as a test compound. The compound is used in industrial applications and as a research reagent. If used in formulation studies, it would be incorporated into topical or other formulations at appropriate concentrations. Standard handling procedures for surfactants should be followed.
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| ADME/Pharmacokinetics |
Sulfonated castor oil has a molecular weight of 422.49 and molecular formula C18H32Na2O6S. It is a light yellow to yellow viscous liquid with a density of 1.06 g/mL at 20°C, boiling point of 121.7°C, and flash point of 109°C. It has a water solubility of 1g/L at 25°C and LogP of 1.4 at 25°C. Storage: 2-8°C. The compound has a pH (10% in water) of 6-8 and non-volatile content of 70-85%.
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| Toxicity/Toxicokinetics |
Sulfonated castor oil is generally considered safe for its intended industrial uses. The compound is for research use only and not for human consumption. Standard laboratory safety practices should be followed when handling this chemical. Appropriate personal protective equipment including gloves and safety glasses should be worn. Specific LD50 values and detailed toxicological profiles have been established for regulatory purposes.
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| Additional Infomation |
Sulfonated castor oil (CAS 8002-33-3) is also known as Turkey red oil, sulphated castor oil, castor oil sulfated sodium salt, and sulforicinolate sodium salt. It has an EINECS number of 232-306-7 and MDL number MFCD00132540. The compound is used as a wetting agent, dispersing agent, levelling agent, detergent, pesticide emulsifier, and metal processing emulsifier. No clinical or therapeutic applications exist.
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| Molecular Formula |
C18H32NA2O6S
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| Molecular Weight |
422.488
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| Exact Mass |
422.171
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| CAS # |
8002-33-3
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| PubChem CID |
167994304
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| Appearance |
Light yellow to yellow liquid
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| Density |
1.06 g/mL at 20 °C
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| Flash Point |
109 °C
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| LogP |
3.35
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
15
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| Heavy Atom Count |
27
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| Complexity |
434
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C(CCC/C=C/CC(CCCCCCS(=O)(=O)[O-])O)CCCC(=O)[O-].[Na+].[Na+]
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| InChi Key |
GBHFRFNAIRYOIZ-KJDUPKRESA-L
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| InChi Code |
InChI=1S/C18H34O6S.2Na/c19-17(14-10-7-8-12-16-25(22,23)24)13-9-5-3-1-2-4-6-11-15-18(20)21;;/h5,9,17,19H,1-4,6-8,10-16H2,(H,20,21)(H,22,23,24);;/q;2*+1/p-2/b9-5+;;
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| Chemical Name |
disodium;(E)-12-hydroxy-18-sulfonatooctadec-9-enoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3669 mL | 11.8346 mL | 23.6692 mL | |
| 5 mM | 0.4734 mL | 2.3669 mL | 4.7338 mL | |
| 10 mM | 0.2367 mL | 1.1835 mL | 2.3669 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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