| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Diallyldimethylammonium chloride does not have a defined pharmacological target as it is a chemical reagent and cationic monomer. The compound is used as a monomer for synthesizing water-soluble polymers and in the synthesis of coagulants and retention aids. It is used as a cationic monomer solution for the fabrication of ion-selective polyelectrolytic anodized aluminium oxide membranes for electrical power generation systems. The compound is also used as an absorbent for cationic dyes.
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| ln Vitro |
Diallyldimethylammonium chloride (60 percent in water) is a biochemical reagent that can be utilized in research pertaining to life sciences as an organic compound or biological material.
No specific in vitro pharmacological activity data are available for Diallyldimethylammonium chloride as it is a chemical reagent and industrial chemical. In research settings, the compound is used as a monomer for polymer synthesis and as a flocculant. Its activity is assessed in terms of polymerization efficiency, flocculating properties, and antimicrobial applications rather than direct biological activity. The compound is used in water treatment, paper production, and as a coagulant. |
| ln Vivo |
No specific in vivo pharmacological activity data have been documented for Diallyldimethylammonium chloride as it is not a therapeutic agent. The compound is used primarily in industrial applications including water treatment, paper production, and polymer chemistry. It is not administered to animals for pharmacological evaluation. Its applications are limited to industrial processes and research laboratories.
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| Enzyme Assay |
For non-cellular assays, Diallyldimethylammonium chloride is characterized by standard analytical techniques including NMR, HPLC, and titration to confirm identity and purity. The compound can be evaluated as a monomer in polymerization reactions and as a flocculant in water treatment studies. Typical protocols involve dissolving the compound in aqueous solutions and testing its polymerization or flocculation efficiency. Purity: typically supplied as 65 wt% in water.
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| Cell Assay |
For in vitro cell-based studies, Diallyldimethylammonium chloride is not typically used as a direct test compound. The compound is intended for industrial and polymer chemistry applications. If handled in a biological laboratory context, appropriate safety precautions should be taken due to the cationic nature and potential irritant effects. The compound should be stored in a cool, dry place protected from light and moisture.
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| Animal Protocol |
For in vivo animal studies, Diallyldimethylammonium chloride is not typically administered as a test compound. The compound is used in industrial applications and polymer research. If used in toxicological studies, it would be administered via appropriate routes with suitable formulations. Adverse effects after intermittent oral doses of 42 grams/kg over 6 weeks include weight loss and changes in the liver and renal tubules.
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| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Male albino rats were placed in metabolic cages. Following perfusion with 14C-diallyldimethylammonium chloride (DADMAC), one animal was collected at each time point, and urine and feces were collected at 24, 48, and 72 hours. Animals were treated with 656 mg/kg (24 hours), 1585 mg/kg (48 hours), or 1591 mg/kg (72 hours) of 14C-DADMAC (100 μCurie/mL: 100 μCurie/0.9 g, purity not specified). Animal carcasses were frozen, and radioactivity was subsequently measured in blood, spleen, liver, kidneys, bone marrow, and three gastrointestinal segments. After removal of skin and feet, the carcasses were homogenized and radioactivity was measured. Despite significant limitations in this study, it demonstrates that DADMAC uptake is low. No changes in clinical symptoms were observed in the treated animals. Slight weight loss occurred during the study period. DADMAC monomer-derived 14C is primarily excreted in feces. …Merzontal tissue concentrations were extremely low at all time points and did not accumulate in any organ. The highest concentration was observed in the liver, reaching 0.0034% of the administered radioactivity at 24 hours. DADMAC uptake is low. The liver showed the highest uptake among the tissues studied. The primary route of excretion is via feces, followed by urine, with only a very small amount expelled through exhaled air. Maximum clearance was observed within the first 24 hours. Diallyldimethylammonium chloride has a molecular weight of 161.67 and molecular formula C8H16ClN. It is typically supplied as a 65 wt% solution in water. Storage: keep in a cool, dry place protected from light and moisture. The compound is a hydrophilic quaternary ammonium compound that can be dissolved in an aqueous solution as a positively charged colloid. |
| Toxicity/Toxicokinetics |
Non-Human Toxicity Values
Oral LD50 in rats (Wistar): 3930 mg/kg Oral LD50 in rats (Sprague-Dawley): 2520 mg/kg Diallyldimethylammonium chloride is classified as an irritant. The compound is for research and industrial use only and not for human consumption. Standard laboratory safety practices should be followed when handling this chemical. Appropriate personal protective equipment including gloves and safety glasses should be worn. Specific LD50 values and detailed toxicological profiles have been established for regulatory purposes. |
| Additional Infomation |
See also: Polyquaternium-6 (15000 MW) (Note moved to).
Diallyldimethylammonium chloride (CAS 7398-69-8) is also known as DADMAC and N,N-dimethyl-N-2-propenyl-2-propen-1-aminium chloride. It is used as a cationic monomer for water-soluble polymers, flocculants, and coagulants for water treatment. Applications include paper production, textiles, personal care products, and as a conditioning agent, emulsifier, and antistatic agent. No clinical trials or therapeutic approvals exist. |
| Molecular Formula |
C8H16CLN
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|---|---|
| Molecular Weight |
161.67
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| Exact Mass |
161.097
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| CAS # |
7398-69-8
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| Related CAS # |
26062-79-3;28301-34-0 (Parent)
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| PubChem CID |
33286
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| Appearance |
Solid
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| Density |
(25ºC)=1.04
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| Boiling Point |
100ºC
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| Melting Point |
140-148 °C
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| Index of Refraction |
n20/D 1.460
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
10
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| Complexity |
91.1
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C=CC[N+](C)(C)CC=C.[Cl-]
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| InChi Key |
GQOKIYDTHHZSCJ-UHFFFAOYSA-M
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| InChi Code |
InChI=1S/C8H16N.ClH/c1-5-7-9(3,4)8-6-2;/h5-6H,1-2,7-8H2,3-4H3;1H/q+1;/p-1
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| Chemical Name |
dimethyl-bis(prop-2-enyl)azanium;chloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.1854 mL | 30.9272 mL | 61.8544 mL | |
| 5 mM | 1.2371 mL | 6.1854 mL | 12.3709 mL | |
| 10 mM | 0.6185 mL | 3.0927 mL | 6.1854 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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