| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
N-Caproicacid sodium targets Hydroxycarboxylic acid receptor 2 (HCAR2) as an agonist with an EC50 of 113 μM. The compound is an anionic surfactant and sodium salt of caproic acid. It is used in drug formulation to enhance solubility and bioavailability.
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|---|---|
| ln Vitro |
N-caproicacidsodium salt is a biochemical reagent that can be utilized in studies pertaining to life sciences as an organic compound or biological material.
In vitro studies have characterized N-Caproicacid sodium as an agonist for Hydroxycarboxylic acid receptor 2 with an EC50 of 113 μM. The compound is used as a biochemical reagent in life science research. Its activity is assessed in receptor activation assays and surfactant applications. |
| ln Vivo |
No specific in vivo pharmacological activity data have been documented for N-Caproicacid sodium as a therapeutic agent. The compound is used as a biochemical reagent and food preservative. If used in animal studies, it would be administered via appropriate routes for receptor agonist studies or formulation research.
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| Enzyme Assay |
For non-cellular assays, N-Caproicacid sodium is characterized by standard analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity and purity. The compound can be evaluated as a receptor agonist in binding assays. Typical protocols involve dissolving the compound in appropriate buffers. Purity: 99%.
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| Cell Assay |
For in vitro cell-based studies, N-Caproicacid sodium can be used to assess Hydroxycarboxylic acid receptor 2 activation. Cells expressing HCAR2 are cultured under standard conditions and treated with the compound to evaluate receptor activation and downstream signaling. The compound is typically dissolved in aqueous buffers. Appropriate controls should be included.
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| Animal Protocol |
For in vivo animal studies, N-Caproicacid sodium can be formulated using standard injection vehicles. The compound is a solid at room temperature. Dosing solutions should be freshly prepared and administered according to specific protocols with appropriate control groups.
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| ADME/Pharmacokinetics |
N-Caproicacid sodium has a molecular weight of 138.14 and molecular formula C6H11NaO2. It appears as a white solid. Purity: 99%. Storage: keep in a cool, dry place protected from light and moisture. The compound is stable under recommended storage conditions.
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| Toxicity/Toxicokinetics |
N-Caproicacid sodium is for research use only and not for human consumption. Standard laboratory safety practices should be followed when handling this chemical. Appropriate personal protective equipment including gloves and safety glasses should be worn. Specific LD50 values and detailed toxicological profiles have been established for food additive safety assessment.
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| Additional Infomation |
Sodium hexanoate is an organic sodium salt formed by replacing the proton on the carboxyl group of hexanoate with a sodium ion. It plays a role in human metabolism. It contains the hexanoate ion.
N-Caproicacid sodium (CAS 10051-44-2) is also known as sodium hexanoate, sodium caproate, and hexanoic acid sodium salt. It is a highly pure biochemical reagent that acts as an agonist for Hydroxycarboxylic acid receptor 2 (EC50=113 μM). It is used as a food preservative, surfactant, and in pharmaceutical formulations. |
| Molecular Formula |
C6H11NAO2
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|---|---|
| Molecular Weight |
138.14
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| Exact Mass |
138.066
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| CAS # |
10051-44-2
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| Related CAS # |
N-Caproicacid-d11 sodium;340257-58-1;N-Caproicacid-d3 sodium;1219794-91-8
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| PubChem CID |
4087444
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| Appearance |
White to off-white solid powder
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| Boiling Point |
204.6ºC at 760mmHg
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| Melting Point |
-3.4ºC
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| Flash Point |
90.3ºC
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| Vapour Pressure |
0.158mmHg at 25°C
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| LogP |
0.316
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
9
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| Complexity |
73.5
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
[Na+].[O-]C(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=O
|
| InChi Key |
UDWXLZLRRVQONG-UHFFFAOYSA-M
|
| InChi Code |
InChI=1S/C6H12O2.Na/c1-2-3-4-5-6(7)8;/h2-5H2,1H3,(H,7,8);/q;+1/p-1
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| Chemical Name |
sodium;hexanoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.2390 mL | 36.1952 mL | 72.3903 mL | |
| 5 mM | 1.4478 mL | 7.2390 mL | 14.4781 mL | |
| 10 mM | 0.7239 mL | 3.6195 mL | 7.2390 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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