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| Other Sizes |
| Targets |
Diphenyliodonium iodide targets reactive oxygen species (ROS) generation. The compound inhibits the accumulation of bisdemethoxycurcumin in fresh-cut yam by inhibiting the phenylpropanoid pathway and the biosynthesis of bisdemethoxycurcumin, thereby preventing the yellowing of fresh-cut yam. It does not have a defined pharmacological target for therapeutic applications.
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| ln Vitro |
Diphenyliodonium iodide is a biochemical reagent that can be utilized in studies pertaining to life sciences as an organic substance or biological material.
In vitro studies have demonstrated that Diphenyliodonium iodide is an inhibitor of reactive oxygen species (ROS) generation. The compound can inhibit the phenylpropanoid pathway and the biosynthesis of bisdemethoxycurcumin. Its activity is assessed in terms of ROS inhibition and prevention of browning in plant tissues. |
| ln Vivo |
No specific in vivo pharmacological activity data have been documented for Diphenyliodonium iodide as a therapeutic agent. The compound is used in research applications including medicine and fruit preservation. It is not administered to animals for pharmacological evaluation as a drug candidate.
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| Enzyme Assay |
For non-cellular assays, Diphenyliodonium iodide is characterized by standard analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity and purity. The compound can be evaluated as an inhibitor of ROS generation in biochemical assays. Typical protocols involve measuring ROS levels in the presence of the compound. Purity: 95%.
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| Cell Assay |
For in vitro cell-based studies, Diphenyliodonium iodide can be used to assess inhibition of ROS generation. Cells are cultured under standard conditions and treated with the compound to evaluate effects on ROS levels and oxidative stress. The compound is typically dissolved in appropriate solvents and diluted in cell culture medium. Appropriate controls should be included.
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| Animal Protocol |
For in vivo animal studies, Diphenyliodonium iodide can be formulated using standard injection vehicles. The compound is a solid at room temperature. Dosing solutions should be freshly prepared and administered according to specific protocols with appropriate control groups. Standard handling procedures for iodonium compounds should be followed.
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| ADME/Pharmacokinetics |
Diphenyliodonium iodide has a molecular weight of 408.02 and molecular formula C12H10I2. Purity: 95%. Storage: keep in a cool, dry place protected from light and moisture. The compound is a solid at room temperature. Solubility: soluble in common organic solvents. The compound is stable under recommended storage conditions.
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| Toxicity/Toxicokinetics |
Diphenyliodonium iodide is for research use only and not for human consumption. Standard laboratory safety practices should be followed when handling this chemical. Iodonium compounds should be handled with care. Appropriate personal protective equipment including gloves and safety glasses should be worn. Specific LD50 values and detailed toxicological profiles have not been extensively reported.
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| Additional Infomation |
Diphenyliodonium iodide (CAS 2217-79-0) is an inhibitor of reactive oxygen species (ROS) generation. It finds applications in medicine and fruit preservation. The compound inhibits the phenylpropanoid pathway and the biosynthesis of bisdemethoxycurcumin, preventing yellowing of fresh-cut yam. It is used as a biochemical reagent in life science research.
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| Molecular Formula |
C12H10I2
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|---|---|
| Molecular Weight |
408.02
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| Exact Mass |
407.887
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| CAS # |
2217-79-0
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| Related CAS # |
10182-84-0 (Parent)
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| PubChem CID |
102228
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| Appearance |
White to yellow solid powder
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| Melting Point |
162-164°C
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
14
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| Complexity |
116
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| Defined Atom Stereocenter Count |
0
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| SMILES |
[I+](C1C([H])=C([H])C([H])=C([H])C=1[H])C1C([H])=C([H])C([H])=C([H])C=1[H].[I-]
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| InChi Key |
WQIRVUAXANLUPO-UHFFFAOYSA-M
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| InChi Code |
InChI=1S/C12H10I.HI/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12;/h1-10H;1H/q+1;/p-1
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| Chemical Name |
diphenyliodanium;iodide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4509 mL | 12.2543 mL | 24.5086 mL | |
| 5 mM | 0.4902 mL | 2.4509 mL | 4.9017 mL | |
| 10 mM | 0.2451 mL | 1.2254 mL | 2.4509 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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