| Size | Price | |
|---|---|---|
| Other Sizes |
Purity: ≥97%
| Targets |
trans-2-Decenal acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC50 of 9.484 μg/mL against H. pylori urease. It reduces the urease activity of H. pylori and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It disrupts cell wall integrity and damages membrane integrity.
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|---|---|
| ln Vitro |
In vitro studies have demonstrated that trans-2-Decenal exhibits potent antibacterial activity against Helicobacter pylori. The compound alters the morphology of H. pylori, induces bacterial rupture, inhibits biofilm formation, and reduces the number of mature biofilms. It triggers intracellular reactive oxygen species (ROS) accumulation and disrupts mitochondrial membrane potential.
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| ln Vivo |
No specific in vivo pharmacological activity data have been documented for trans-2-Decenal as a therapeutic agent. The compound is used primarily as a flavoring agent, fragrance, and chemical intermediate. It is applicable to studies related to Helicobacter pylori and plant diseases induced by Phytophthora capsici.
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| Enzyme Assay |
For non-cellular assays, trans-2-Decenal is characterized by standard analytical techniques including GC, HPLC, NMR, and mass spectrometry to confirm identity and purity. The compound can be evaluated as a urease inhibitor using enzyme activity assays. Typical protocols involve incubating the compound with urease and measuring residual enzyme activity. Purity: typically ≥95% to ≥98%.
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| Cell Assay |
For in vitro cell-based studies, trans-2-Decenal can be used to assess antibacterial activity against Helicobacter pylori. Bacteria are cultured under standard conditions and treated with the compound to evaluate effects on growth, biofilm formation, and morphology. The compound is typically dissolved in DMSO or appropriate solvents and diluted in culture medium.
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| Animal Protocol |
For in vivo animal studies, trans-2-Decenal can be formulated using standard injection vehicles. The compound is a liquid at room temperature. Dosing solutions should be freshly prepared and administered according to specific protocols with appropriate control groups. The compound is for research use only.
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| ADME/Pharmacokinetics |
trans-2-Decenal has a molecular weight of 154.24 and molecular formula C10H18O. It is a liquid at room temperature. Purity: typically ≥95% to ≥98%. Storage: keep in a cool, dry place protected from light and moisture. The compound is stable under recommended storage conditions. Boiling point: not specified.
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| Toxicity/Toxicokinetics |
trans-2-Decenal is for research use only and not for human consumption. Standard laboratory safety practices should be followed when handling this chemical. Aldehydes can be irritating to skin, eyes, and respiratory system. Appropriate personal protective equipment including gloves and safety glasses should be worn.
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| Additional Infomation |
(2E)-Dec-2-enal is a dec-2-enal with an E configuration in its olefinic double bond. It can be used as an alarm pheromone, nematicide, and mutagen. 2-Decenal has been reported in blueberry (Vaccinium macrocarpon), Cynomorium songaricum, and other organisms with relevant data.
trans-2-Decenal (CAS 3913-81-3) is also known as (E)-dec-2-enal. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals, and dyes. The compound acts as a urease inhibitor and antibacterial agent against Helicobacter pylori. It is also used as a flavoring agent and fragrance component. |
| Molecular Formula |
C10H18O
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|---|---|
| Molecular Weight |
154.25
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| Exact Mass |
154.135
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| CAS # |
3913-81-3
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| PubChem CID |
5283345
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| Appearance |
Colorless to light yellow liquid
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| Density |
0.8±0.1 g/cm3
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| Boiling Point |
230.0±0.0 °C at 760 mmHg
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| Melting Point |
-8.92 °C. @ 760.00 mm Hg
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| Flash Point |
96.1±0.0 °C
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| Vapour Pressure |
0.1±0.4 mmHg at 25°C
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| Index of Refraction |
1.440
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| LogP |
3.7
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| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
7
|
| Heavy Atom Count |
11
|
| Complexity |
105
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CCCCCCC/C=C/C=O
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| InChi Key |
MMFCJPPRCYDLLZ-CMDGGOBGSA-N
|
| InChi Code |
InChI=1S/C10H18O/c1-2-3-4-5-6-7-8-9-10-11/h8-10H,2-7H2,1H3/b9-8+
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| Chemical Name |
(E)-dec-2-enal
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.4830 mL | 32.4149 mL | 64.8298 mL | |
| 5 mM | 1.2966 mL | 6.4830 mL | 12.9660 mL | |
| 10 mM | 0.6483 mL | 3.2415 mL | 6.4830 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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