| Size | Price | Stock | Qty |
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| 100mg |
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| 500mg |
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| 1g |
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| Other Sizes |
| Targets |
The specific drug target of Taloxin has not been reported in the public literature. As a biochemical reagent, its structure contains a sulfonamide group and an indoxyl ester moiety, suggesting potential enzyme inhibitory activity. Research indicates that certain derivatives in this class may act as AHAS (acetohydroxyacid synthase) inhibitors, a key enzyme in branched-chain amino acid biosynthesis. However, direct evidence of Taloxin itself acting on this target is currently unavailable.
Taloxin does not have a defined pharmacological target as it is a chromogenic substrate and biochemical reagent. The compound is characterized by a tosyl-protected L-alanine ester linked to an indole moiety. As a chromogenic indoxyl ester substrate, it is used in enzyme assays and biochemical research. |
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| ln Vitro |
In vitro activity of Taloxin is assessed in chromogenic enzyme assays. The compound serves as a substrate for enzymes that cleave the ester bond, releasing a colored product. This property makes it useful for detecting and measuring enzyme activity in biochemical research.
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| ln Vivo |
No specific in vivo pharmacological activity data have been documented for Taloxin as a therapeutic agent. The compound is used as a chromogenic substrate and biochemical reagent. It is not administered to animals for pharmacological evaluation. Its applications are limited to in vitro biochemical research.
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| Enzyme Assay |
For non-cellular assays, Taloxin is characterized by standard analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. The compound can be evaluated as a chromogenic substrate in enzyme assays. Typical protocols involve incubating the compound with enzyme samples and detecting the colored product. Molecular weight: 358.41.
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| Cell Assay |
For in vitro cell-based studies, Taloxin is not typically used as a direct test compound. The compound is used as a chromogenic substrate in biochemical assays. If handled in a biological laboratory context, standard safety precautions should be taken.
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| Animal Protocol |
For in vivo animal studies, Taloxin is not typically administered as a test compound. The compound is used as a chromogenic substrate in biochemical research. If used in animal studies for specific research purposes, it would be administered via appropriate routes with suitable formulations.
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| ADME/Pharmacokinetics |
Taloxin has a molecular weight of 358.41 and molecular formula C18H18N2O4S. Storage: keep in a cool, dry place protected from light and moisture. The compound is a solid at room temperature. Solubility: soluble in common organic solvents.
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| Toxicity/Toxicokinetics |
Taloxin is for research use only and not for human consumption. Standard laboratory safety practices should be followed when handling this chemical. Appropriate personal protective equipment including gloves and safety glasses should be worn. Specific LD50 values and detailed toxicological profiles have not been extensively reported.
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| Additional Infomation |
Taloxin (CAS 75062-54-3) is also known as (S)-1H-Indol-3-yl 2-(4-methylphenylsulfonamido)propanoate and N-Tosyl-L-alanine 3-indoxyl ester. It is a chromogenic indoxyl ester substrate used in enzyme assays and biochemical research. No clinical trials or therapeutic approvals exist.
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| Molecular Formula |
C18H18N2O4S
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|---|---|
| Molecular Weight |
358.41
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| Exact Mass |
358.098
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| CAS # |
75062-54-3
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| PubChem CID |
14032422
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| Appearance |
White to off-white solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
577.9±60.0 °C at 760 mmHg
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| Melting Point |
38-39ºC
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| Flash Point |
303.3±32.9 °C
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| Vapour Pressure |
0.0±1.6 mmHg at 25°C
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| Index of Refraction |
1.634
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| LogP |
3.71
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
25
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| Complexity |
566
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| Defined Atom Stereocenter Count |
1
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| SMILES |
CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](C)C(=O)OC2=CNC3=CC=CC=C32
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| InChi Key |
CBIVSVOVPJAVRE-ZDUSSCGKSA-N
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| InChi Code |
InChI=1S/C18H18N2O4S/c1-12-7-9-14(10-8-12)25(22,23)20-13(2)18(21)24-17-11-19-16-6-4-3-5-15(16)17/h3-11,13,19-20H,1-2H3/t13-/m0/s1
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| Chemical Name |
1H-indol-3-yl (2S)-2-[(4-methylphenyl)sulfonylamino]propanoate
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| Synonyms |
75062-54-3; 1H-Indol-3-yl N-((4-methylphenyl)sulphonyl)-L-alaninate; DTXSID10226037; RefChem:1090702; DTXCID10148528;
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ～125 mg/mL (348.8 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7901 mL | 13.9505 mL | 27.9010 mL | |
| 5 mM | 0.5580 mL | 2.7901 mL | 5.5802 mL | |
| 10 mM | 0.2790 mL | 1.3951 mL | 2.7901 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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