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| Other Sizes |
| Targets |
Beeswax does not have a defined pharmacological target as it is a natural wax and excipient. The compound is commonly used in cosmetics, pharmaceuticals, and food applications. In pharmaceuticals, it serves as an excipient or inactive ingredient in drug formulations. It is also used in ointments and topical formulations.
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| ln Vitro |
No specific in vitro pharmacological activity data are available for Beeswax as a drug candidate. In research settings, the compound is evaluated for its physical properties and formulation performance rather than direct biological activity. It is used as an excipient and formulation component.
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| ln Vivo |
No specific in vivo pharmacological activity data have been documented for Beeswax as a therapeutic agent. The compound is used as a pharmaceutical excipient and cosmetic ingredient. It is generally considered pharmacologically inert and is not absorbed to a significant extent after topical administration.
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| Enzyme Assay |
For non-cellular assays, Beeswax is characterized by standard analytical techniques including FTIR and physical property testing to confirm identity and quality. The compound can be evaluated for its physical properties including melting point (61-65°C) and density (0.95-0.960).
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| Cell Assay |
For in vitro cell-based studies, Beeswax is not typically used as a direct test compound. The compound is used as an excipient in pharmaceutical formulations that are subsequently tested in cell-based assays. If handled in a biological laboratory context, standard safety precautions should be taken.
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| Animal Protocol |
For in vivo animal studies, Beeswax is used as an excipient in pharmaceutical formulations administered to animals. The compound is generally considered safe for use in topical and oral formulations. Dosing and administration follow the specific formulation protocol.
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| ADME/Pharmacokinetics |
Beeswax has a density of 0.95-0.960 and melting point of 61-65°C. It appears as a light yellow to yellow solid powder. Storage: keep in a cool, dry place protected from light and moisture. The compound is stable under recommended storage conditions.
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| Toxicity/Toxicokinetics |
Beeswax is generally regarded as safe for use as a pharmaceutical excipient and cosmetic ingredient. Standard laboratory safety practices should be followed when handling this compound. Appropriate personal protective equipment including gloves and safety glasses should be worn.
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| Additional Infomation |
Beeswax (CAS 8012-89-3) is also known as honeycomb wax, candle wax, and crude wax. It is a natural wax derived from the honeycombs of bees, consisting primarily of myricyl palmitate, cerotic acid and esters. Applications include cosmetics, pharmaceuticals, and food industries. No therapeutic claims exist for the compound itself.
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| CAS # |
8012-89-3
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|---|---|
| Appearance |
Light yellow to yellow solid powder
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| Density |
0.95-0.960
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| Melting Point |
61-65 °C(lit.)
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| Flash Point |
158 °F
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| Index of Refraction |
n20/D 1.485-1.505
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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