| Size | Price | Stock | Qty |
|---|---|---|---|
| 25g |
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| 50g |
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| Other Sizes |
| Targets |
Glycofurol does not have a defined pharmacological target as it is a pharmaceutical solvent and excipient. The compound is used as a solvent in parenteral products during intravenous or intramuscular injection. It is also used as a penetration enhancer and solvent in topical and intranasal formulations. Its primary function is to dissolve water-insoluble active molecules.
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|---|---|
| ln Vitro |
No specific in vitro pharmacological activity data are available for Glycofurol as a drug candidate. In research settings, the compound is evaluated for its solubilizing properties and biocompatibility. Its activity is assessed in terms of formulation performance and safety rather than direct biological activity.
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| ln Vivo |
No specific in vivo pharmacological activity data have been documented for Glycofurol as a therapeutic agent. The compound is used as a pharmaceutical solvent and excipient. It is generally considered pharmacologically inert and is not administered for therapeutic purposes but as a formulation component.
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| Enzyme Assay |
For non-cellular assays, Glycofurol is characterized by standard analytical techniques including physical property testing to confirm identity and quality. The compound is a liquid with excellent solubility in both polar and non-polar systems. It is a low-volatility, low-toxicity solvent alternative. Purity: typically ≥99%. Storage: keep in a cool, dry place protected from light and moisture.
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| Cell Assay |
For in vitro cell-based studies, Glycofurol may be used as a solvent for hydrophobic test compounds in cell culture. The compound is typically dissolved in aqueous buffers or cell culture medium at appropriate concentrations. Cells are cultured under standard conditions and exposed to Glycofurol-containing formulations to assess biocompatibility.
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| Animal Protocol |
For in vivo animal studies, Glycofurol may be used as an excipient in drug formulations for administration via various routes including intravenous and intramuscular injection. The compound is typically formulated with active pharmaceutical ingredients to improve solubility. Dosing solutions should be prepared according to the specific formulation protocol. Standard animal welfare guidelines should be followed.
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| ADME/Pharmacokinetics |
Glycofurol has a CAS number of 31692-85-0. It appears as a liquid. Purity: typically ≥99%. Storage: keep in a cool, dry place protected from light and moisture. The compound is a low-volatility, low-toxicity solvent with excellent solubility in both polar and non-polar systems.
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| Toxicity/Toxicokinetics |
Glycofurol is for research and pharmaceutical use only and not for human consumption without regulatory approval. Standard laboratory safety practices should be followed when handling this compound. Appropriate personal protective equipment including gloves and safety glasses should be worn. The compound is generally regarded as safe for use as a pharmaceutical excipient at appropriate concentrations.
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| Additional Infomation |
See also: Glycofurol (note moved to).
Glycofurol (CAS 31692-85-0) is also known as poly(ethylene glycol) tetrahydrofurfuryl ether, tetraglycol, and tetrahydrofurfuryl alcohol polyethyleneglycol ether. It is used as a solvent in parenteral products, as a penetration enhancer in topical and intranasal formulations, and in inks, coatings, and resin systems. No therapeutic claims exist for the compound itself. |
| Molecular Formula |
(C2H4O)NC5H10O2
|
|---|---|
| Molecular Weight |
233.28
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| Exact Mass |
146.094
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| CAS # |
31692-85-0
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| Related CAS # |
31692-85-0
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| PubChem CID |
110717
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| Appearance |
Colorless to light yellow liquid
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| Density |
1.061g/cm3
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| Boiling Point |
256.2ºC at 760mmHg
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| Flash Point |
108.7ºC
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| Index of Refraction |
1.454
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| LogP |
-0.2
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
10
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| Complexity |
84.9
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| Defined Atom Stereocenter Count |
0
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| SMILES |
OCCOCC1CCCO1
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| InChi Key |
CTPDSKVQLSDPLC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C7H14O3/c8-3-5-9-6-7-2-1-4-10-7/h7-8H,1-6H2
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| Chemical Name |
2-(oxolan-2-ylmethoxy)ethanol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.2867 mL | 21.4335 mL | 42.8669 mL | |
| 5 mM | 0.8573 mL | 4.2867 mL | 8.5734 mL | |
| 10 mM | 0.4287 mL | 2.1433 mL | 4.2867 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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