| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
(±)-Reticuline does not have a defined pharmacological target as it is a natural product and biochemical reagent. The compound serves as a precursor for the synthesis of S-reticuline. Reticuline is an isoquinolinol and benzylisoquinoline alkaloid that is a plant metabolite. It has been reported in various organisms and is involved in maintaining the structural integrity of organs as a component of reticuline fibers.
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| ln Vitro |
No specific in vitro pharmacological activity data are available for (±)-Reticuline as a drug candidate. In research settings, the compound is used as a biochemical reagent and natural product reference standard. Its activity is assessed in terms of its role as a precursor for alkaloid synthesis and its natural product chemistry properties rather than direct biological activity.
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| ln Vivo |
No specific in vivo pharmacological activity data have been documented for (±)-Reticuline as a therapeutic agent. The compound is used as a biochemical reagent and natural product. It is not administered to animals for pharmacological evaluation. Its applications are limited to natural product chemistry and biochemical research.
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| Enzyme Assay |
For non-cellular assays, (±)-Reticuline is characterized by standard analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity and purity. Purity is typically ≥98%. The compound has a density of 1.2±0.1 g/cm³, boiling point of 504.9±50.0°C, and LogP of 2.09. It has 2 hydrogen bond donors, 5 acceptors, and 4 rotatable bonds. Storage: powder at -20°C for 3 years or 4°C for 2 years.
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| Cell Assay |
For in vitro cell-based studies, (±)-Reticuline is not typically used as a direct test compound. It is used as a biochemical reagent and natural product reference standard. If handled in a biological laboratory context, standard safety precautions should be taken. The compound should be stored in a sealed, protected environment.
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| Animal Protocol |
For in vivo animal studies, (±)-Reticuline can be formulated using standard injection vehicles. The compound is a solid at room temperature. Dosing solutions should be freshly prepared and administered according to specific protocols with appropriate control groups. The compound is stable at ambient temperature for a few days during shipping.
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| ADME/Pharmacokinetics |
(±)-Reticuline has a molecular weight of 329.39 and formula C₁₉H₂₃NO₄. It has a density of 1.2±0.1 g/cm³, boiling point of 504.9±50.0°C, and flash point of 259.2±30.1°C. LogP: 2.09. The compound has 2 hydrogen bond donors, 5 acceptors, and 4 rotatable bonds. Storage: powder at -20°C for 3 years or 4°C for 2 years; in solvent at -80°C for 6 months or -20°C for 1 month.
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| Toxicity/Toxicokinetics |
(±)-Reticuline is for research use only and not for human consumption. Standard laboratory safety practices should be followed when handling this chemical. Appropriate personal protective equipment including gloves and safety glasses should be worn. Specific LD₅₀ values and detailed toxicological profiles have not been extensively reported.
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| References | |
| Additional Infomation |
Reticuline is an isoquinolinol, benzyltetrahydroisoquinoline, and benzylisoquinoline alkaloid. It is a plant metabolite and the conjugate base of reticularin (1+). Reticuline has been reported in Corydalis ternata, Neolitsea konishii, and other organisms with relevant data. Reticuline is a hard protein fiber mainly composed of type III collagen. Reticuline fibers are very fine, ranging from 0.5 to 2 micrometers in diameter. They are involved in maintaining the structural integrity of various organs. See also: Reticuline (note moved to).
(±)-Reticuline (CAS 1699-46-3) is also known as 1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinol and (RS)-reticuline. It is a natural product extracted from Peumus boldus Molina that serves as a precursor for the synthesis of S-reticuline. No clinical trials or therapeutic approvals exist. |
| Molecular Formula |
C19H23NO4
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|---|---|
| Molecular Weight |
329.39
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| Exact Mass |
329.162
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| CAS # |
1699-46-3
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| Related CAS # |
485-19-8;3968-19-2
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| PubChem CID |
10233
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| Appearance |
White to off-white solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
504.9±50.0 °C at 760 mmHg
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| Flash Point |
259.2±30.1 °C
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| Vapour Pressure |
0.0±1.3 mmHg at 25°C
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| Index of Refraction |
1.604
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| LogP |
2.09
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
24
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| Complexity |
407
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CN1CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)O)O)OC
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| InChi Key |
BHLYRWXGMIUIHG-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C19H23NO4/c1-20-7-6-13-10-19(24-3)17(22)11-14(13)15(20)8-12-4-5-18(23-2)16(21)9-12/h4-5,9-11,15,21-22H,6-8H2,1-3H3
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| Chemical Name |
1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0359 mL | 15.1796 mL | 30.3591 mL | |
| 5 mM | 0.6072 mL | 3.0359 mL | 6.0718 mL | |
| 10 mM | 0.3036 mL | 1.5180 mL | 3.0359 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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