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| Other Sizes |
| Targets |
Tetramethylammonium fluoride tetrahydrate does not have a defined pharmacological target as it is a chemical reagent. The compound is used as a source of fluoride ion in organic synthesis. Its primary applications are in palladium-catalyzed reactions and fluorination reactions. It is not designed to interact with biological targets but is used as a reagent in chemical transformations.
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| ln Vitro |
Tetramethylammonium fluoride tetrahydrate is a biochemical reagent that can be utilized in life science research as an organic substance or biological material.
No specific in vitro pharmacological activity data are available for Tetramethylammonium fluoride tetrahydrate as it is a chemical reagent. In research settings, the compound is used as a fluoride source in organic synthesis. Its activity is assessed in terms of reactivity and synthetic utility rather than direct biological activity. |
| ln Vivo |
No specific in vivo pharmacological activity data have been documented for Tetramethylammonium fluoride tetrahydrate as it is not a therapeutic agent. The compound is used exclusively as a chemical reagent. It is not administered to animals for pharmacological evaluation. Its applications are limited to organic synthesis research.
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| Enzyme Assay |
For non-cellular assays, Tetramethylammonium fluoride tetrahydrate is characterized by standard analytical techniques including NMR and elemental analysis to confirm identity and purity. Purity is typically ≥98%. The compound has a melting point of 39-42°C. Solubility: soluble in water; slightly soluble in methanol. Storage: keep in dark place, sealed in dry, 2-8°C. The compound is hygroscopic.
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| Cell Assay |
For in vitro cell-based studies, Tetramethylammonium fluoride tetrahydrate is not typically used as a direct test compound. It is a chemical reagent for synthetic chemistry applications. If handled in a biological laboratory context, appropriate safety precautions should be taken due to the fluoride content. The compound is a solid at room temperature.
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| Animal Protocol |
For in vivo animal studies, Tetramethylammonium fluoride tetrahydrate is not typically administered as a test compound. It is used as a chemical reagent. If used in toxicological studies, it would be administered via appropriate routes with suitable formulations. Standard animal welfare guidelines should be followed.
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| ADME/Pharmacokinetics |
Tetramethylammonium fluoride tetrahydrate has a molecular weight of 165.21 and formula C₄H₁₂FN·4H₂O. It has a melting point of 39-42°C and flash point >230°F. Solubility: soluble in water; slightly soluble in methanol. Storage: keep in dark place, sealed in dry, 2-8°C. The compound is hygroscopic and appears as colorless to white crystalline low melting mass.
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| Toxicity/Toxicokinetics |
Tetramethylammonium fluoride tetrahydrate is classified with GHS07, signal word Warning, and hazard statements H315-H319-H335. Precautionary statements include P261-P264-P271-P280-P302+P352-P305+P351+P338. Risk statements: R36/37/38 (irritating to eyes, respiratory system, and skin). The compound is for research use only and not for human consumption. Appropriate personal protective equipment should be worn.
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| Additional Infomation |
Tetramethylammonium fluoride tetrahydrate (CAS 17787-40-5) is also known as tetramethylammonium fluoride tetrahydrate and methanaminium, N,N,N-trimethyl-, fluoride, tetrahydrate. It is used as a reactant for homocoupling of aryl halides, in cross-coupling reactions with alkenylsilanols, and in fluorination reactions. No clinical trials or therapeutic approvals exist.
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| Molecular Formula |
C4H22FNO5
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|---|---|
| Molecular Weight |
183.22
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| Exact Mass |
165.137
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| CAS # |
17787-40-5
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| PubChem CID |
2723808
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| Appearance |
Colorless to off-white <39°C powder,>42°C liquid
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| Melting Point |
39-42 °C(lit.)
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| Flash Point |
>230 °F
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
10
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| Complexity |
19.1
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| Defined Atom Stereocenter Count |
0
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| SMILES |
[F-].O([H])[H].O([H])[H].O([H])[H].O([H])[H].[N+](C([H])([H])[H])(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
|
| InChi Key |
HQFTZNVQVRRDLN-UHFFFAOYSA-M
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| InChi Code |
InChI=1S/C4H12N.FH.4H2O/c1-5(2,3)4;;;;;/h1-4H3;1H;4*1H2/q+1;;;;;/p-1
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| Chemical Name |
tetramethylazanium;fluoride;tetrahydrate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.4579 mL | 27.2896 mL | 54.5792 mL | |
| 5 mM | 1.0916 mL | 5.4579 mL | 10.9158 mL | |
| 10 mM | 0.5458 mL | 2.7290 mL | 5.4579 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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