| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
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| Other Sizes |
Purity: ≥98%
| Targets |
Carboxybetaine methacrylate does not have a defined pharmacological target as it is a biochemical reagent and monomer. The compound is used to prepare tissue engineering scaffolds, drug carriers, and other biomedical materials. Its zwitterionic nature provides high hydrophilicity and biocompatibility, making it ideal for developing biomedical materials. Its primary applications are in materials science and biomedical engineering.
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|---|---|
| ln Vitro |
No specific in vitro pharmacological activity data are available for Carboxybetaine methacrylate as a drug candidate. In research settings, the compound is evaluated for its polymerization properties, biocompatibility, and ability to form hydrogels. Its activity is assessed in terms of material performance rather than direct biological activity. The compound is used as a monomer for polymer synthesis.
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| ln Vivo |
No specific in vivo pharmacological activity data have been documented for Carboxybetaine methacrylate as a therapeutic agent. The compound is used as a monomer and biomaterial for preparing tissue engineering scaffolds and drug delivery systems. It is not administered to animals for pharmacological evaluation. Its applications are limited to materials science and biomedical engineering research.
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| Enzyme Assay |
For non-cellular assays, Carboxybetaine methacrylate is characterized by standard analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity and purity. Purity is typically ≥98%. The compound has a melting point of 101°C (dec.), LogP of -3.87, and a topological polar surface area of 66.4 Ų. It has 0 hydrogen bond donors and 4 acceptors. Storage: powder at -20°C for 3 years or 4°C for 2 years.
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| Cell Assay |
For in vitro cell-based studies, Carboxybetaine methacrylate is not typically used as a direct test compound. It is used as a monomer for synthesizing polymers that are subsequently evaluated in cell-based assays for biocompatibility and tissue engineering applications. If handled in a biological laboratory context, standard safety precautions should be taken.
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| Animal Protocol |
For in vivo animal studies, Carboxybetaine methacrylate is not typically administered as a test compound. It is used to prepare tissue engineering scaffolds and drug delivery systems that are subsequently evaluated in animal models. The compound can be formulated using vehicles such as DMSO:Tween 80:Saline (10:5:85) if required.
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| ADME/Pharmacokinetics |
Carboxybetaine methacrylate has a molecular weight of 229.27 and formula C₁₁H₁₉NO₄. It has a melting point of 101°C (dec.) and LogP of -3.87. The compound has 0 hydrogen bond donors and 4 acceptors. Storage: powder at -20°C for 3 years or 4°C for 2 years; in solvent at -80°C for 6 months or -20°C for 1 month. Shipping: room temperature.
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| Toxicity/Toxicokinetics |
Carboxybetaine methacrylate is for research use only and not for human consumption. Standard laboratory safety practices should be followed when handling this chemical. Appropriate personal protective equipment including gloves and safety glasses should be worn. The compound should be stored in a sealed and protected environment, avoiding exposure to moisture.
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| Additional Infomation |
Carboxybetaine methacrylate (CAS 24249-95-4) is also known as 3-[[2-(methacryloyloxy)ethyl]dimethylammonio]propionate and CBMA. It is an amphoteric ionic monomer with high hydrophilicity, antistatic properties, and biocompatibility. Applications include tissue engineering scaffolds, drug delivery carriers, and other biomedical materials. No clinical trials or therapeutic approvals exist.
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| Molecular Formula |
C11H19NO4
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|---|---|
| Molecular Weight |
229.27
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| Exact Mass |
229.131
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| CAS # |
24249-95-4
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| Related CAS # |
26338-17-0
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| PubChem CID |
57605655
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| Appearance |
White to off-white solid powder
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| Melting Point |
101 °C(dec.)
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| LogP |
-3.87
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
16
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| Complexity |
278
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O(C(C(=C([H])[H])C([H])([H])[H])=O)C([H])([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)[O-]
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| InChi Key |
CSWRCKVZMMKVDC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C11H19NO4/c1-9(2)11(15)16-8-7-12(3,4)6-5-10(13)14/h1,5-8H2,2-4H3
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| Chemical Name |
3-[dimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azaniumyl]propanoate
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| Synonyms |
24249-95-4; 3-[[2-(Methacryloyloxy)ethyl]dimethylammonio]propionate; 3-((2-(Methacryloyloxy)ethyl)dimethylammonio)propanoate; MFCD28386109; 3-[dimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azaniumyl]propanoate; SCHEMBL536434; DTXSID201299321; BS-45751;
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.3617 mL | 21.8083 mL | 43.6167 mL | |
| 5 mM | 0.8723 mL | 4.3617 mL | 8.7233 mL | |
| 10 mM | 0.4362 mL | 2.1808 mL | 4.3617 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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