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| Other Sizes |
| Targets |
4-Aminobenzamide targets poly(ADP-ribose) polymerase (PARP) as an inhibitor, studied for its potential in cancer therapy and DNA repair modulation. By inhibiting PARP, the compound interferes with DNA repair mechanisms in cancer cells. It is also used as an anti-tuberculosis drug, inhibiting the activity of Mycobacterium tuberculosis. The compound serves as a pharmacological tool for studying DNA repair pathways.
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| ln Vitro |
4-Aminobenzamide is employed as a poly(ADP-ribose) polymerase (PADPRP) inhibitor to investigate how cytotoxic effector cells cause target cell death via ribozyme poly(ADP-ribose) polymerase (PADPRP).
In vitro studies have demonstrated that 4-Aminobenzamide acts as a PARP inhibitor, making it a valuable tool for studying DNA repair mechanisms. The compound has been investigated for its anticancer properties and its ability to sensitize cancer cells to DNA-damaging agents. It also exhibits anti-tuberculosis activity. Its activity is assessed in enzyme inhibition assays and cell-based DNA repair studies. |
| ln Vivo |
No specific in vivo pharmacological activity data have been documented for 4-Aminobenzamide as a therapeutic agent in humans. The compound is a research chemical and PARP inhibitor studied for its potential in cancer therapy. If used in animal studies, it would be administered for DNA repair research or anti-tuberculosis studies. Its applications are primarily in research settings.
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| Enzyme Assay |
For non-cellular assays, 4-Aminobenzamide is characterized by standard analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. Purity is typically ≥98%. The compound has a melting point of 181-185°C and molecular weight of 136.15. Storage: room temperature in a cool and dark place (<15°C). The compound appears as a white to off-white crystalline solid.
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| Cell Assay |
For in vitro cell-based studies, 4-Aminobenzamide is used as a PARP inhibitor to study DNA repair mechanisms. Cells are cultured under standard conditions and treated with the compound to evaluate effects on PARP activity and DNA damage response. The compound is typically dissolved in DMSO or appropriate buffers and diluted in cell culture medium. Appropriate controls should be included in the experimental design.
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| Animal Protocol |
For in vivo animal studies, 4-Aminobenzamide can be formulated using standard injection vehicles. The compound is a solid at room temperature. Dosing solutions should be freshly prepared and administered according to specific protocols with appropriate control groups. Standard handling procedures for amides should be followed. The compound is studied for its potential in cancer therapy and DNA repair modulation.
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| ADME/Pharmacokinetics |
4-Aminobenzamide has a molecular weight of 136.15 and formula C₇H₈N₂O. It has a melting point of 181-185°C. Purity: ≥98%. Storage: room temperature in a cool and dark place (<15°C). The compound appears as a white to off-white crystalline solid. Solubility: soluble in organic solvents.
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| Toxicity/Toxicokinetics |
4-Aminobenzamide is for research use only and not for human consumption. Standard laboratory safety practices should be followed when handling this chemical. Appropriate personal protective equipment including gloves and safety glasses should be worn. Specific LD₅₀ values and detailed toxicological profiles have not been extensively reported.
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| Additional Infomation |
4-Aminobenzamide is a type of benzamide compound.
4-Aminobenzamide (CAS 2835-68-9) is also known as p-aminobenzamide. It is a poly(ADP-ribose) polymerase (PARP) inhibitor studied for its potential in cancer therapy and DNA repair modulation. It is also used as an anti-tuberculosis drug and as an intermediate in pharmaceutical production. No clinical trials or therapeutic approvals exist for this compound as a drug. |
| Molecular Formula |
C7H8N2O
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|---|---|
| Molecular Weight |
136.15
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| Exact Mass |
136.063
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| CAS # |
2835-68-9
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| PubChem CID |
76079
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| Appearance |
White to off-white solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
349.0±25.0 °C at 760 mmHg
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| Melting Point |
181-183 °C(lit.)
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| Flash Point |
164.9±23.2 °C
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| Vapour Pressure |
0.0±0.8 mmHg at 25°C
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| Index of Refraction |
1.633
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| LogP |
0.09
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
10
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| Complexity |
128
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C(N)C1=CC=C(N)C=C1
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| InChi Key |
QIKYZXDTTPVVAC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C7H8N2O/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H2,9,10)
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| Chemical Name |
4-aminobenzamide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.3448 mL | 36.7242 mL | 73.4484 mL | |
| 5 mM | 1.4690 mL | 7.3448 mL | 14.6897 mL | |
| 10 mM | 0.7345 mL | 3.6724 mL | 7.3448 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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