| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
Phosphocholine chloride disodium does not have a defined pharmacological target as it is a biochemical reagent and liposome component. The compound is used to prepare cell membranes and liposomes for drug delivery systems. In the pharmaceutical industry, it serves as a stabilizer and surfactant. Its primary function is formulation-based rather than therapeutic, as it provides structural support for lipid-based delivery vehicles and enhances the solubility of incorporated active pharmaceutical ingredients.
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| ln Vitro |
No specific in vitro pharmacological activity data are available for Phosphocholine chloride disodium as a drug candidate. In research settings, the compound is evaluated for its ability to form stable liposomes and cell membrane mimics. Its activity is assessed in terms of liposome formation efficiency, encapsulation capacity, and membrane integrity rather than direct biological activity. The compound is used as a biochemical reagent for life science research.
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| ln Vivo |
No specific in vivo pharmacological activity data have been documented for Phosphocholine chloride disodium as a therapeutic agent. The compound is used as a biomaterial and formulation component for drug delivery systems. It is not administered directly to animals for pharmacological evaluation. Its applications are limited to ex vivo formulation development and in vitro biochemical research. The compound is not intended for diagnostic or therapeutic use.
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| Enzyme Assay |
For non-cellular assays, Phosphocholine chloride disodium is characterized by standard analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. The compound can be evaluated for its ability to form liposomes and cell membrane structures. Typical protocols involve dissolving the compound in aqueous buffers and assessing liposome formation using dynamic light scattering and electron microscopy. Purity is typically ≥98.0%. The compound should be stored as a powder at -20°C for up to 3 years or at 4°C for up to 2 years; in solvent at -80°C for 6 months or -20°C for 1 month.
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| Cell Assay |
For in vitro cell-based studies, Phosphocholine chloride disodium may be used as a component of liposomal formulations for drug delivery research. The compound is typically dissolved in aqueous buffers and incorporated into liposome preparations. Cells are cultured under standard conditions and treated with liposome-encapsulated compounds to assess delivery efficiency and biocompatibility. Appropriate controls including liposomes without the compound should be included in the experimental design.
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| Animal Protocol |
For in vivo animal studies, Phosphocholine chloride disodium may be used as an excipient in liposomal drug formulations for administration via various routes. The compound is typically formulated with active pharmaceutical ingredients to improve solubility and bioavailability. Dosing solutions should be prepared according to the specific formulation protocol. Standard animal welfare guidelines should be followed for all in vivo studies. The compound is not intended for therapeutic use in animals without appropriate formulation and regulatory approval.
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| ADME/Pharmacokinetics |
Phosphocholine chloride disodium has a molecular weight of 263.57 g·mol⁻¹ and molecular formula C₅H₁₃ClNNa₂O₄P. It appears as a white to off-white solid. Storage: powder at -20°C for up to 3 years or at 4°C for up to 2 years; in solvent at -80°C for 6 months or -20°C for 1 month. Transport: room temperature in continental US. The compound is soluble in aqueous buffers. Purity: ≥98.0%.
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| Toxicity/Toxicokinetics |
Phosphocholine chloride disodium is for research use only and not for human therapeutic or diagnostic use. Standard laboratory safety practices should be followed when handling this chemical. Specific LD₅₀ values and detailed toxicological profiles have not been extensively reported. Appropriate personal protective equipment including gloves and safety glasses should be worn when handling the compound. The compound should be stored in a sealed container away from moisture and incompatible materials.
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| Additional Infomation |
Phosphocholine chloride disodium (CAS 16904-96-4) is also known as phosphatidylcholine sodium salt. It is a biochemical compound containing phosphate, choline, and chloride ions. The compound is commonly employed in preparing cell membranes and liposomes for drug delivery systems. In the pharmaceutical industry, it has various applications, particularly as a stabilizer and surfactant. No clinical trials or regulatory approvals for human use exist, as the product is exclusively for research purposes.
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| Molecular Formula |
C5H13CLNNA2O4P
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|---|---|
| Molecular Weight |
263.57
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| Exact Mass |
263.006
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| CAS # |
16904-96-4
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| PubChem CID |
85635
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| Appearance |
White to off-white solid powder
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
14
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| Complexity |
147
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C[N+](C)(C)CCOP(=O)([O-])[O-].[Na+].[Na+].[Cl-]
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| InChi Key |
HMCRHROSIPYRGL-UHFFFAOYSA-L
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| InChi Code |
InChI=1S/C5H14NO4P.ClH.2Na/c1-6(2,3)4-5-10-11(7,8)9;;;/h4-5H2,1-3H3,(H-,7,8,9);1H;;/q;;2*+1/p-2
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| Chemical Name |
disodium;2-(trimethylazaniumyl)ethyl phosphate;chloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O: 250 mg/mL (948.51 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7941 mL | 18.9703 mL | 37.9406 mL | |
| 5 mM | 0.7588 mL | 3.7941 mL | 7.5881 mL | |
| 10 mM | 0.3794 mL | 1.8970 mL | 3.7941 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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