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| Other Sizes |
| Targets |
Tetrabutylammonium tetrafluoroborate does not have a defined pharmacological target as it is a phase transfer catalyst and electrolyte. The compound is used as an electrolyte for the synthesis of aryl ketones and as a phase transfer catalyst. Due to its low nucleophilicity and weak coordinating ability, it serves as a stable and non-interfering electrolyte. Its compatibility with organic solvents and high ionic conductivity make it valuable in electrolyte formulations.
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| ln Vitro |
Tetrabutylammonium fluoroborate is a biochemical reagent that can be utilized in research pertaining to life sciences as an organic compound or biological material.
No specific in vitro pharmacological activity data are available for Tetrabutylammonium tetrafluoroborate as it is a chemical reagent and electrolyte. In research settings, the compound is used as a phase transfer catalyst and electrolyte in electrochemical studies. Its activity is assessed in terms of ionic conductivity, catalytic efficiency, and electrochemical performance rather than biological activity. The compound is extensively used in organic synthesis, such as fluorination reactions, olefin addition and cyclization reactions. |
| ln Vivo |
No specific in vivo pharmacological activity data have been documented for Tetrabutylammonium tetrafluoroborate as a therapeutic agent. The compound is used exclusively as a chemical reagent and electrolyte. It is not administered to animals for pharmacological evaluation. Its applications are limited to organic synthesis, electrochemistry, and analytical chemistry laboratories.
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| Enzyme Assay |
For non-cellular assays, Tetrabutylammonium tetrafluoroborate is characterized by standard analytical techniques including NMR, HPLC, and elemental analysis to confirm identity and purity. Purity is ≥98.0% (with total nitrogen). The compound has a melting point of 160.0 to 163.0°C and appears as a white to almost white powder to crystal. Solubility: methanol: 0.1 g/mL, clear, colorless. Storage: −20°C.
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| Cell Assay |
For in vitro cell-based studies, Tetrabutylammonium tetrafluoroborate is not typically used as a direct test compound. It is a chemical reagent for synthetic chemistry and electrochemical applications. If handled in a biological laboratory context, appropriate safety precautions should be taken due to the hygroscopic nature and potential irritant properties. The compound is a solid at room temperature.
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| Animal Protocol |
For in vivo animal studies, Tetrabutylammonium tetrafluoroborate is not typically administered as a test compound. It is used as a chemical reagent and electrolyte. If used in toxicological studies, it would be administered via appropriate routes with suitable formulations. Standard animal welfare guidelines should be followed.
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| ADME/Pharmacokinetics |
The compound has a molecular weight of 329.27 and molecular formula C₁₆H₃₆BF₄N. It appears as a white to almost white powder to crystal with a melting point of 160.0 to 163.0°C. Solubility: slightly soluble in water; methanol: 0.1 g/mL, clear, colorless. Storage: −20°C. The compound is hygroscopic.
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| Toxicity/Toxicokinetics |
The compound is for research use only and not for human consumption. Standard laboratory safety practices should be followed when handling this chemical. The compound is hygroscopic and should be stored in a sealed container. Appropriate personal protective equipment including gloves and safety glasses should be worn. Specific LD₅₀ values and detailed toxicological profiles have not been extensively reported.
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| Additional Infomation |
When used with bis-GMA, it forms a resin that releases fluorides.
Tetrabutylammonium tetrafluoroborate (CAS 429-42-5) is also known as TBATFB and tetra-n-butylammonium tetrafluoroborate. It is a phase transfer catalyst and electrolyte used in organic synthesis reactions including fluorination reactions, olefin addition and cyclization reactions. Its compatibility with organic solvents and high ionic conductivity make it valuable in electrolyte formulations. The compound plays a vital role in advancing electrochemical technologies and analytical chemistry applications. No clinical trials or therapeutic approvals exist. |
| Molecular Formula |
C16H36BF4N
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|---|---|
| Molecular Weight |
329.27
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| Exact Mass |
329.287
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| CAS # |
429-42-5
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| PubChem CID |
67932
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| Appearance |
White to off-white solid powder
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| Melting Point |
155-161 °C(lit.)
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| LogP |
6.303
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
12
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| Heavy Atom Count |
22
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| Complexity |
135
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CCCC[N+](CCCC)(CCCC)CCCC.[B-](F)(F)(F)F
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| InChi Key |
NNZZSJSQYOFZAM-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H36N.BF4/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;2-1(3,4)5/h5-16H2,1-4H3;/q+1;-1
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| Chemical Name |
tetrabutylazanium;tetrafluoroborate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (303.70 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0370 mL | 15.1851 mL | 30.3702 mL | |
| 5 mM | 0.6074 mL | 3.0370 mL | 6.0740 mL | |
| 10 mM | 0.3037 mL | 1.5185 mL | 3.0370 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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