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| Other Sizes |
| Targets |
Pentaerythrityl tetrastearate does not have a defined pharmacological target as it is a pharmaceutical excipient and biochemical reagent. The compound is utilized within the pharmaceutical sector as an excipient for drug formulations, boasting exceptional lubricating attributes. It also exhibits good emulsifying properties, which can enhance the texture and consistency of products. Its primary function is as an excipient and formulation component rather than as a therapeutic agent.
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| ln Vitro |
Pentaerythrityl tetrastearate is a biochemical reagent that can be utilized in studies pertaining to life sciences as an organic substance or biological material.
No specific in vitro pharmacological activity data are available for Pentaerythrityl tetrastearate as it is a pharmaceutical excipient and biochemical reagent. In research settings, the compound is evaluated for its lubricating properties, emulsifying properties, and compatibility with active pharmaceutical ingredients. Its activity is assessed in terms of formulation performance and physical properties rather than direct biological activity. The compound is generally regarded as safe for use in food and cosmetic applications. |
| ln Vivo |
No specific in vivo pharmacological activity data have been documented for Pentaerythrityl tetrastearate as a therapeutic agent. The compound is used as a pharmaceutical excipient and is generally considered pharmacologically inert. It is not administered for therapeutic purposes but as a formulation component in drug products. Its applications are limited to pharmaceutical formulation and cosmetic product development.
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| Enzyme Assay |
For non-cellular assays, Pentaerythrityl tetrastearate is characterized by standard analytical techniques including HPLC, FTIR, and physical property testing to confirm identity and quality. The compound can be evaluated for its lubricating properties, melting point, and emulsifying properties. Typical protocols involve testing the compound's physical and chemical properties. Density: 0.915-0.94 g/cm³. Flash point: 342.4°C. Melting point: 60-66°C.
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| Cell Assay |
For in vitro cell-based studies, Pentaerythrityl tetrastearate is not typically used as a direct test compound. It is used as an excipient in pharmaceutical formulations that are subsequently tested in cell-based assays. If handled in a biological laboratory context, standard safety precautions should be taken. The compound is a solid at room temperature and should be stored in a cool, dry place.
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| Animal Protocol |
For in vivo animal studies, Pentaerythrityl tetrastearate may be used as an excipient in drug formulations for administration via various routes. The compound is generally considered safe for use in pharmaceutical formulations at appropriate concentrations. Dosing and administration follow the specific formulation protocol. Standard animal welfare guidelines should be followed for all in vivo studies.
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| ADME/Pharmacokinetics |
Pentaerythrityl tetrastearate has a molecular weight of approximately 1202.02 g/mol and molecular formula C₇₇H₁₄₈O₈. It appears as a white, waxy solid at room temperature with a melting point of 60-66°C. Density: 0.915-0.94 g/cm³. Flash point: 342.4°C. Solubility: insoluble in water, soluble in organic solvents such as oils and fats. Storage: keep in a cool, dry place.
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| Toxicity/Toxicokinetics |
Toxicity Summary
It is safe at the current usage and concentration. Ingredient, concentration, and usage information can be found at: https://cir-reports.cir-safety.org Pentaerythrityl tetrastearate is for research use only and not for human consumption without appropriate formulation and regulatory approval. Standard laboratory safety practices should be followed when handling this compound. Appropriate personal protective equipment including gloves and safety glasses should be worn. The compound is generally regarded as safe for use in food and cosmetic applications at appropriate concentrations. |
| Additional Infomation |
Pentaerythrityl tetrastearate (CAS 115-83-3) is also known as pentaerythritol tetrastearate. It is a synthetic wax ester utilized within the pharmaceutical sector as an excipient for drug formulations, boasting exceptional lubricating attributes. It exhibits good emulsifying properties, which can enhance the texture and consistency of products. The compound is generally regarded as safe for use in food and cosmetic applications. No therapeutic claims exist for the compound itself.
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| Molecular Formula |
C146H280O16
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|---|---|
| Molecular Weight |
2291.78
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| Exact Mass |
1201.117
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| CAS # |
115-83-3
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| PubChem CID |
61037
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| Appearance |
White to off-white solid powder
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| Density |
0.9±0.1 g/cm3
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| Boiling Point |
998.5±60.0 °C at 760 mmHg
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| Melting Point |
60-66 °C
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| Flash Point |
342.4±32.9 °C
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| Vapour Pressure |
0.0±0.3 mmHg at 25°C
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| Index of Refraction |
1.469
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| LogP |
34.01
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
76
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| Heavy Atom Count |
85
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| Complexity |
1180
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CCCCCCCCCCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCCCCCCCC)(COC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC
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| InChi Key |
OCKWAZCWKSMKNC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C77H148O8/c1-5-9-13-17-21-25-29-33-37-41-45-49-53-57-61-65-73(78)82-69-77(70-83-74(79)66-62-58-54-50-46-42-38-34-30-26-22-18-14-10-6-2,71-84-75(80)67-63-59-55-51-47-43-39-35-31-27-23-19-15-11-7-3)72-85-76(81)68-64-60-56-52-48-44-40-36-32-28-24-20-16-12-8-4/h5-72H2,1-4H3
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| Chemical Name |
[3-octadecanoyloxy-2,2-bis(octadecanoyloxymethyl)propyl] octadecanoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.4363 mL | 2.1817 mL | 4.3634 mL | |
| 5 mM | 0.0873 mL | 0.4363 mL | 0.8727 mL | |
| 10 mM | 0.0436 mL | 0.2182 mL | 0.4363 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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