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| Other Sizes |
| Targets |
2-Ethoxyphenol inhibits bacterial growth by binding to the enzyme monoethyl ether reductase (MEOR), preventing the formation of a functional MEOR complex and blocking the production of NADPH, which is essential for aerobic respiration. It is a smoke flavour compound and forms complexes with iron (III). It has been shown to have activity in the ER agonist pathway.
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| ln Vitro |
2-Ethoxyphenol is a biochemical reagent that can be utilized in life science research as an organic compound or biological material.
In vitro studies have shown that 2-Ethoxyphenol inhibits bacterial growth by binding to the enzyme monoethyl ether reductase (MEOR). It has been used as a carbon and energy supplement in the growth medium of Rhodococcus rhodochrous strain 116. The compound is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
| ln Vivo |
No specific in vivo pharmacological activity data have been documented for 2-Ethoxyphenol as a therapeutic agent. The compound is used as a flavoring agent and biochemical reagent. It is not administered to animals for pharmacological evaluation. Its applications are limited to flavor, food, and biochemical research.
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| Enzyme Assay |
For non-cellular assays, 2-Ethoxyphenol is characterized by standard analytical techniques including GC, HPLC, NMR, and mass spectrometry to confirm identity and purity. The compound has a molecular weight of 138.16 and molecular formula C₈H₁₀O₂. Purity: typically ≥98%. Storage: room temperature in a cool and dry place. The compound is a liquid at room temperature.
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| Cell Assay |
For in vitro cell-based studies, 2-Ethoxyphenol can be used to assess antibacterial activity. Bacteria are cultured under standard conditions and treated with the compound to evaluate effects on growth and metabolism. The compound is typically dissolved in appropriate solvents and diluted in culture medium. Appropriate controls should be included in the experimental design.
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| Animal Protocol |
For in vivo animal studies, 2-Ethoxyphenol is not typically administered as a test compound. It is used as a flavoring agent and biochemical reagent. If used in animal studies for specific research purposes, it would be administered via appropriate routes with suitable formulations. Standard animal welfare guidelines should be followed.
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| ADME/Pharmacokinetics |
2-Ethoxyphenol has a molecular weight of 138.16 and molecular formula C₈H₁₀O₂. Purity: typically ≥98%. Storage: keep in a cool, dry place protected from light and moisture. The compound is a liquid at room temperature. Solubility: soluble in organic solvents.
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| Toxicity/Toxicokinetics |
2-Ethoxyphenol is for research use only and not for human consumption. Standard laboratory safety practices should be followed when handling this chemical. Appropriate personal protective equipment including gloves and safety glasses should be worn. Specific LD₅₀ values and detailed toxicological profiles have been established for flavor safety assessment.
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| Additional Infomation |
2-Ethoxyphenol is an aromatic ether, formed by the alkylation of a hydroxyl group in a catechol molecule. It is a smoky flavor compound with a low melting point (20-25℃) and a high boiling point (216-217℃), and can be used as a flavoring agent. It is an aromatic ether, belonging to the class of volatile organic compounds and is a member of the phenolic family. Its functional group is related to catechol.
2-Ethoxyphenol (CAS 94-71-3) is also known as guaiacol ethyl ether and guethol. It is a smoke flavour compound that inhibits bacterial growth by binding to monoethyl ether reductase (MEOR). It is commonly used as a flavoring agent in foods. No clinical trials or therapeutic approvals exist. |
| Molecular Formula |
C8H10O2
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|---|---|
| Molecular Weight |
138.16
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| Exact Mass |
138.068
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| CAS # |
94-71-3
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| Related CAS # |
2-Ethoxyphenol-d5;117320-30-6
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| PubChem CID |
66755
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| Appearance |
Colorless to off-white <20°C solid powder,>25°C liquid
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
219.4±13.0 °C at 760 mmHg
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| Melting Point |
20-25 °C(lit.)
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| Flash Point |
91.1±0.0 °C
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| Vapour Pressure |
0.1±0.4 mmHg at 25°C
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| Index of Refraction |
1.527
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| LogP |
1.72
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
10
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| Complexity |
93.3
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| Defined Atom Stereocenter Count |
0
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| SMILES |
OC1C(OCC)=CC=CC=1
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| InChi Key |
MOEFFSWKSMRFRQ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C8H10O2/c1-2-10-8-6-4-3-5-7(8)9/h3-6,9H,2H2,1H3
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| Chemical Name |
2-ethoxyphenol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.2380 mL | 36.1899 mL | 72.3798 mL | |
| 5 mM | 1.4476 mL | 7.2380 mL | 14.4760 mL | |
| 10 mM | 0.7238 mL | 3.6190 mL | 7.2380 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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