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| Other Sizes |
| Targets |
Cyclohexyldiphenylphosphine does not have a defined pharmacological target as it is a chemical reagent and ligand. The compound is widely utilized in transition metal catalysis, including palladium-catalyzed cross-couplings and rhodium-catalyzed hydroformylation. Its primary function is to serve as a ligand that stabilizes metal catalysts and enhances their reactivity and selectivity in organic transformations.
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| ln Vitro |
No specific in vitro pharmacological activity data are available for Cyclohexyldiphenylphosphine as it is a chemical reagent. In research settings, the compound is used as a ligand in catalytic reactions. Its activity is assessed in terms of catalytic efficiency and ligand performance rather than direct biological activity. The compound is a biochemical reagent for biomedical research.
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| ln Vivo |
No specific in vivo pharmacological activity data have been documented for Cyclohexyldiphenylphosphine as a therapeutic agent. The compound is used exclusively as a chemical reagent and ligand in catalysis. It is not administered to animals for pharmacological evaluation. Its applications are limited to organic synthesis and catalysis research.
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| Enzyme Assay |
For non-cellular assays, Cyclohexyldiphenylphosphine is characterized by standard analytical techniques including GC, HPLC, NMR, and mass spectrometry to confirm identity and purity. Purity is min. 97.0%. The compound has a melting point of 59.0 to 62.0°C. Storage: room temperature in a cool and dark place (<15°C). Typical protocols involve using the compound as a ligand in transition metal-catalyzed reactions.
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| Cell Assay |
For in vitro cell-based studies, Cyclohexyldiphenylphosphine is not typically used as a direct test compound. It is a ligand and chemical reagent for catalytic applications. If handled in a biological laboratory context, standard safety precautions should be taken. The compound should be stored in a cool, dry place protected from light and moisture.
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| Animal Protocol |
For in vivo animal studies, Cyclohexyldiphenylphosphine is not typically administered as a test compound. It is used as a chemical reagent and ligand in catalysis research. If used in toxicological studies, it would be administered via appropriate routes with suitable formulations. Standard animal welfare guidelines should be followed.
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| ADME/Pharmacokinetics |
Cyclohexyldiphenylphosphine has a molecular weight of 268.34 g/mol and molecular formula C₁₈H₂₁P. It has a melting point of 59.0 to 62.0°C. Purity: min. 97.0%. Storage: room temperature in a cool and dark place (<15°C). The compound appears as a white to almost white powder to crystal.
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| Toxicity/Toxicokinetics |
Cyclohexyldiphenylphosphine is for research use only and not for human consumption. Standard laboratory safety practices should be followed when handling this chemical. Phosphine derivatives should be handled with care. Appropriate personal protective equipment including gloves and safety glasses should be worn. Specific LD₅₀ values and detailed toxicological profiles have not been extensively reported.
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| Additional Infomation |
Cyclohexyldiphenylphosphine (CAS 6372-42-5) is also known as dicyclohexylphenylphosphine and CyPPh₂. It is a monodentate tertiary phosphine ligand widely utilized in transition metal catalysis, including palladium-catalyzed cross-couplings and rhodium-catalyzed hydroformylation. The compound is a biochemical reagent for biomedical research. No clinical trials or therapeutic approvals exist.
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| Molecular Formula |
C18H21P
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|---|---|
| Molecular Weight |
268.34
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| Exact Mass |
268.138
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| CAS # |
6372-42-5
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| PubChem CID |
80756
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| Appearance |
White to off-white solid powder
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| Boiling Point |
374.0±11.0 °C at 760 mmHg
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| Melting Point |
58-62 °C(lit.)
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| Flash Point |
189.4±25.6 °C
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| Vapour Pressure |
0.0±0.8 mmHg at 25°C
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| LogP |
6.38
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
0
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
19
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| Complexity |
226
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
P(C1C([H])=C([H])C([H])=C([H])C=1[H])(C1C([H])=C([H])C([H])=C([H])C=1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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| InChi Key |
ZXKWUYWWVSKKQZ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C18H21P/c1-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-2,4-7,10-13,18H,3,8-9,14-15H2
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| Chemical Name |
cyclohexyl(diphenyl)phosphane
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7266 mL | 18.6331 mL | 37.2662 mL | |
| 5 mM | 0.7453 mL | 3.7266 mL | 7.4532 mL | |
| 10 mM | 0.3727 mL | 1.8633 mL | 3.7266 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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