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| Targets |
5-Hydroxyquinoline is a synthetic intermediate and fragment molecule with chelating properties. As a building block, it does not have specific biological receptors as its primary targets. The quinoline scaffold is a privileged structure in medicinal chemistry, found in many drugs including antimalarials and antibacterials. The hydroxyl group provides a handle for further derivatization, and the compound can act as a lipophilic chelator for metal ions. Its primary applications are as a synthetic intermediate for drug discovery and as a chelating agent.
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| ln Vitro |
5-Hydroxyquinoline is a biochemical reagent that can be utilized in research pertaining to life sciences as an organic compound or biological material.
In vitro, 5-hydroxyquinoline is used as a biochemical reagent and organic compound for biomedical research. It is used as an internal standard for measuring morphine concentration in serum or plasma and as a lipophilic chelator. It is a fragment molecule for drug discovery. Cellular assays may evaluate its chelating properties, cytotoxicity, or the activity of compounds synthesized from it. The compound's quinoline scaffold allows for various chemical transformations. |
| ln Vivo |
In vivo data for 5-hydroxyquinoline is limited, as it is primarily a research reagent and synthetic intermediate. The compound is classified for research use only and is not intended for human or veterinary therapeutic applications. Its use as an internal standard for measuring morphine concentration suggests it is used in analytical methods rather than as a therapeutic agent. The compound's primary value lies in its use as a synthetic intermediate and research tool. Specific in vivo data for therapeutic applications is not available in the public literature.
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| Enzyme Assay |
In vitro assays for 5-hydroxyquinoline typically evaluate its chelating properties or its use as an analytical standard. A standard protocol for chelation studies involves incubating the compound with metal ions in appropriate buffer systems. Chelation is assessed by UV-Vis spectroscopy or fluorescence spectroscopy. For analytical applications, the compound is used as an internal standard in HPLC or LC-MS methods for measuring morphine concentration. The compound's purity and stability are critical for analytical applications. The compound's binding affinity for metal ions can be determined from titration experiments.
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| Cell Assay |
Cellular assays for 5-hydroxyquinoline are not standard, as the compound is primarily used as an analytical standard and synthetic intermediate. The compound's quinoline structure and chelating properties suggest potential for cytotoxicity at high concentrations. Any cellular studies would focus on evaluating the compound's cytotoxicity or its effects on metal ion homeostasis. A typical protocol would involve culturing appropriate cell lines in growth medium at 37°C with 5% CO₂. Cells would be treated with varying concentrations of the compound. Cell viability would be assessed using MTT or similar assays.
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| Animal Protocol |
In vivo animal studies for 5-hydroxyquinoline are not standard, as it is primarily a research reagent. The compound is classified for research use only and is not intended for human or veterinary applications. Any animal studies would be limited to evaluating its use as an analytical standard or its toxicological profile. The compound's primary value lies in its use as a synthetic intermediate and research tool. Specific in vivo protocols are not available in the public literature.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for 5-hydroxyquinoline is limited, as it is primarily a research reagent. The compound has a molecular weight of 145.16 g/mol and a molecular formula of C₉H₇NO. It is a solid at room temperature with a melting point of 223-226°C. It has a LogP of 1.94. As a hydroxyquinoline, it may undergo metabolic conjugation (glucuronidation, sulfation) and oxidation. Specific ADME data is not available. The compound is stored in a dry, cool place.
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| Toxicity/Toxicokinetics |
5-Hydroxyquinoline is classified for research use only and is not intended for human or veterinary applications. Standard safety precautions include handling with appropriate personal protective equipment (gloves, lab coat, safety goggles) in a well-ventilated area. The compound should be stored in a dry, cool place away from incompatible materials. Acute toxicity data is not readily available in the public literature. As with all research chemicals, appropriate laboratory safety practices should be followed. No specific LD₅₀ values are available in the public domain.
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| Additional Infomation |
Quinolin-5-ol is a monohydroxyquinoline.
5-Hydroxyquinoline (Quinolin-5-ol, CAS 578-67-6) is a biochemical reagent with the molecular formula C₉H₇NO and a molecular weight of 145.16 g/mol. It is used as an internal standard for measuring morphine concentration in serum or plasma and as a lipophilic chelator. The compound is classified as a research-use-only reagent and is available from multiple commercial suppliers. |
| Molecular Formula |
C9H7NO
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|---|---|
| Molecular Weight |
145.16
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| Exact Mass |
145.052
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| CAS # |
578-67-6
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| PubChem CID |
135441757
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| Appearance |
Light green to green solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
313.0±15.0 °C at 760 mmHg
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| Melting Point |
223-226 °C(lit.)
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| Flash Point |
143.1±20.4 °C
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| Vapour Pressure |
0.0±0.7 mmHg at 25°C
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| Index of Refraction |
1.691
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| LogP |
1.45
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
11
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| Complexity |
138
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O([H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=N2
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| InChi Key |
GYESAYHWISMZOK-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C9H7NO/c11-9-5-1-4-8-7(9)3-2-6-10-8/h1-6,11H
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| Chemical Name |
quinolin-5-ol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.8890 mL | 34.4448 mL | 68.8895 mL | |
| 5 mM | 1.3778 mL | 6.8890 mL | 13.7779 mL | |
| 10 mM | 0.6889 mL | 3.4445 mL | 6.8890 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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