| Size | Price | Stock | Qty |
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| 5g |
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| Targets |
Palmityl acetate does not have a defined biological target as it is a fatty acid ester and research reagent rather than a pharmacologically active compound. Its function is biochemical—it serves as a lipid standard for analytical chemistry and as a model compound for studying fatty acid ester metabolism. As a fatty acid ester, it can be hydrolyzed by esterases to release hexadecanol and acetate. The compound itself is not evaluated for biological activity against specific targets. Its interactions with biological systems are limited to its role as a lipid molecule.
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| ln Vitro |
In vitro, palmityl acetate exhibits no pharmacological activity as it is a fatty acid ester. Its utility is demonstrated in lipid analysis as a chromatographic standard for the identification and quantification of fatty acid esters by GC or LC-MS. The compound is also used in studies of lipid metabolism and esterase activity. In cell-based assays, fatty acid esters can be taken up by cells and incorporated into lipid droplets or metabolized by esterases. However, palmityl acetate is not used as a therapeutic agent. Its role is strictly analytical and biochemical.
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| ln Vivo |
Palmityl acetate is not a pharmacologically active agent and does not exhibit in vivo therapeutic activity. It is used as a lipid standard and research reagent. The compound is not intended for human or animal exposure as a therapeutic agent. It is used in research laboratories for lipid analysis and biochemical studies. No therapeutic efficacy has been reported for this compound. The compound is not administered to animals in pharmacological studies.
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| Enzyme Assay |
In vitro assays for palmityl acetate focus on its use as a lipid standard rather than receptor binding. A standard protocol involves preparing solutions of the compound in organic solvents (hexane, chloroform) and using it as a standard for GC or LC-MS analysis of fatty acid esters. The compound is also used as a substrate for esterase activity assays, where esterase enzymes hydrolyze the ester bond, and the released hexadecanol or acetate is measured by enzymatic or colorimetric methods. Quality control includes GC purity analysis and melting point determination.
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| Cell Assay |
In vitro cell culture experiments with palmityl acetate typically involve studies of lipid metabolism. Cells are cultured in appropriate media and treated with the fatty acid ester at concentrations ranging from 1-100 µM for 24-72 hours. Cellular lipid content is measured by lipid extraction followed by GC or LC-MS analysis. Esterase activity can be measured by monitoring the hydrolysis of the ester bond. Cell viability is assessed using MTT assays to ensure that observed effects are not due to cytotoxicity.
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| Animal Protocol |
In vivo animal studies with palmityl acetate are not well documented, as the compound is primarily used as a research reagent and lipid standard. If conducted, typical protocols for fatty acid ester administration would involve oral gavage or intravenous injection in rodents. Blood samples would be collected for pharmacokinetic analysis and lipid profiling. However, such studies are not standard for this compound as it is not a drug candidate.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of palmityl acetate are not well characterized as it is not a drug substance. As a long-chain fatty acid ester with a molecular weight of 284.48 and high lipophilicity, the compound would be expected to be absorbed through the gastrointestinal tract and metabolized by esterases to hexadecanol and acetate. The fatty alcohol would be further metabolized via fatty acid oxidation pathways. However, formal pharmacokinetic studies have not been conducted as the compound is not intended for human use.
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| Toxicity/Toxicokinetics |
Toxicity Summary
It is safe at the current usage and concentration. Ingredient, concentration, and usage information can be found at: https://cir-reports.cir-safety.org Palmityl acetate is generally considered to have low toxicity as a fatty acid ester. Standard laboratory precautions should be followed when handling the compound, including the use of gloves and safety glasses. The compound should be stored in a cool, dry place away from light and moisture. No acute toxicity data are available. The compound is not intended for drug, household, or other uses. |
| Additional Infomation |
Palmityl acetate is an acetate derived from hexadecane-1-ol (palmitol); it can be used as an emollient, masking agent, and skin conditioning agent; it is also a pheromone component in various mice, arachnids, and insects. It possesses multiple functions, including cosmetic, pheromone, and epitope effects. Its functions are related to hexadecane-1-ol. Hexadecyl acetate has been reported in Sesamia grisescens, Flavobacterium, and other organisms with relevant data.
Palmityl acetate is a fatty acid ester used as a chromatographic standard for lipid analysis and in biochemical research. It is also known as hexadecyl acetate. The compound has not undergone clinical trials and is not approved as a pharmaceutical. Its mechanism of action is biochemical—serving as a standard and model compound for lipid analysis and esterase studies. |
| Molecular Formula |
C18H36O2
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|---|---|
| Molecular Weight |
284.48
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| Exact Mass |
284.272
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| CAS # |
629-70-9
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| PubChem CID |
12393
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| Appearance |
Colorless to light yellow liquid
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| Density |
0.864g/cm3
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| Boiling Point |
323.5ºC at 760 mmHg
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| Flash Point |
146.1ºC
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| Index of Refraction |
1.442
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| LogP |
6.03
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
16
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| Heavy Atom Count |
20
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| Complexity |
202
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CCCCCCCCCCCCCCCCOC(C)=O
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| InChi Key |
LSTDYDRCKUBPDI-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C18H36O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20-18(2)19/h3-17H2,1-2H3
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| Chemical Name |
hexadecyl acetate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.5152 mL | 17.5759 mL | 35.1519 mL | |
| 5 mM | 0.7030 mL | 3.5152 mL | 7.0304 mL | |
| 10 mM | 0.3515 mL | 1.7576 mL | 3.5152 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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