| Size | Price | |
|---|---|---|
| Other Sizes |
Purity: ≥98%
| Targets |
(1S,2S)-Cyclohexane-1,2-diamine does not have a defined biological target as it is a chiral scaffold and chemical reagent rather than a pharmacologically active compound. Its function is chemical—it serves as a chiral building block for the synthesis of more complex molecules. The C2-symmetric vicinal diamine structure enables the formation of chiral metal complexes and ligands for asymmetric catalysis. When incorporated into pharmaceutical compounds, the cyclohexanediamine scaffold can interact with biological targets through hydrogen bonding and hydrophobic interactions. The compound itself is not evaluated for biological activity against specific targets. Its role is to provide chirality to synthetic intermediates and final drug candidates, enabling enantioselective synthesis and resolution.
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| ln Vitro |
For the production of goods with optical activity.
As a chemical reagent, (1S,2S)-cyclohexane-1,2-diamine exhibits no intrinsic pharmacological activity in vitro. Its utility is demonstrated in the synthesis of macrocyclic [3+3] hexa Schiff bases and in the preparation of multidentate ligands, chiral auxiliaries, and chiral stationary phases for chromatographic resolution. The compound serves as a privileged chiral scaffold in asymmetric catalysis, coordination chemistry, and chromatographic separation. In cell-based assays, the compound itself is not tested for biological activity. Instead, the products synthesized from this reagent are evaluated for their pharmacological properties. The compound is used exclusively as a chiral building block in organic synthesis and medicinal chemistry research. |
| ln Vivo |
(1S,2S)-Cyclohexane-1,2-diamine does not exhibit in vivo biological activity as it is not a therapeutic agent. The compound is used as a chiral scaffold in asymmetric catalysis and coordination chemistry. Any in vivo effects would be associated with the final products synthesized from this intermediate, not with the intermediate itself. The compound is not administered to animals in pharmacological studies and has no known physiological effects. Its role is strictly chemical—providing a versatile C2-symmetric diamine scaffold for constructing complex chiral molecules with potential pharmaceutical applications. The compound is intended for laboratory research use only and is not suitable for human or veterinary applications.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays are not applicable to (1S,2S)-cyclohexane-1,2-diamine as it is not a biologically active compound. Standard characterization protocols for this reagent include nuclear magnetic resonance (¹H NMR, ¹³C NMR) and mass spectrometry to confirm structure and purity. Optical rotation measurement is used to confirm enantiomeric purity. Melting point determination and GC or HPLC analysis (>98% purity) are used for quality control. For synthetic applications, typical reactions include the use of the diamine as a chiral ligand for metal-catalyzed asymmetric reactions (e.g., Ru-catalyzed hydrogenation), as a building block for macrocycle synthesis, and as a chiral stationary phase component for chromatographic resolution of racemic compounds.
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| Cell Assay |
Cell-based experiments are not performed with (1S,2S)-cyclohexane-1,2-diamine itself, as it is a chemical reagent rather than a test compound for biological activity. When the compound is used to synthesize drug candidates, those products may be tested in cell culture using standard protocols. Typically, final compounds are dissolved in DMSO and diluted in culture medium to achieve desired concentrations (typically 0.1-100 µM). Cells are incubated for 24-72 hours, and effects on cell viability, proliferation, or specific signaling pathways are measured using appropriate assays such as MTT, CellTiter-Glo, or flow cytometry. The intermediate itself is not evaluated in cellular systems as it is not intended to have biological activity.
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| Animal Protocol |
In vivo animal studies are not conducted with (1S,2S)-cyclohexane-1,2-diamine, as it is a research reagent for chemical synthesis. When the compound is used to synthesize drug candidates, those final products undergo standard preclinical evaluation. Typical protocols for drug candidates include pharmacokinetic studies in rodents (oral or intravenous administration, blood sampling for LC-MS/MS analysis), efficacy studies in disease models, and toxicology studies (acute and repeated-dose toxicity, histopathology). These studies evaluate the safety and efficacy of the final drug molecules, not the synthetic intermediate. The compound is not used as a therapeutic test article and has no established in vivo pharmacological profile.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of (1S,2S)-cyclohexane-1,2-diamine are not characterized as it is not a drug substance. Based on its physicochemical properties (molecular weight 114.19, very soluble in water, logP approximately -0.5), the compound would be expected to have low oral bioavailability due to poor membrane permeability. It would likely be distributed primarily in extracellular fluid and rapidly cleared via renal excretion. The compound may be metabolized via N-acetylation or oxidation. However, the compound is not intended for human exposure and has not been evaluated in formal pharmacokinetic studies. For drug candidates synthesized from this intermediate, pharmacokinetic properties are determined as part of drug development.
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| Toxicity/Toxicokinetics |
(1S,2S)-Cyclohexane-1,2-diamine may cause skin and eye irritation. Standard laboratory safety precautions should be followed when handling this compound, including the use of gloves, safety glasses, and working in a fume hood. The compound is a combustible solid (storage class 11) and should be stored in a cool, dry place away from moisture and strong oxidizing agents. No acute toxicity, mutagenicity, or carcinogenicity data are available. The compound is not intended for drug, household, or other uses. In case of contact, rinse with water and seek medical advice if irritation persists.
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| Additional Infomation |
(1S,2S)-Cyclohexane-1,2-diamine is a C2-symmetric vicinal diamine that serves as a privileged chiral scaffold in asymmetric catalysis, coordination chemistry, and chromatographic resolution. It is also known as (1S,2S)-(+)-1,2-diaminocyclohexane and (S,S)-DACH. The compound is used in the synthesis of macrocyclic [3+3] hexa Schiff bases and in the preparation of multidentate ligands, chiral auxiliaries, and chiral stationary phases. It is a key component in the synthesis of various chiral catalysts for enantioselective reactions. The compound has not undergone clinical trials and is not approved as a pharmaceutical. Its mechanism of action is chemical—serving as a chiral building block for asymmetric synthesis.
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| Molecular Formula |
C6H14N2
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|---|---|
| Molecular Weight |
114.19
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| Exact Mass |
114.115
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| CAS # |
21436-03-3
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| Related CAS # |
(1R,2R)-Cyclohexane-1,2-diamine;20439-47-8
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| PubChem CID |
479307
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| Appearance |
White to light yellow <40°C solid powder,>43°C liquid
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| Density |
0.9±0.1 g/cm3
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| Boiling Point |
193.6±0.0 °C at 760 mmHg
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| Melting Point |
40-43 °C(lit.)
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| Flash Point |
75.0±0.0 °C
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| Vapour Pressure |
0.5±0.3 mmHg at 25°C
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| Index of Refraction |
1.484
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| LogP |
-0.12
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
8
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| Complexity |
62.9
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| Defined Atom Stereocenter Count |
2
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| SMILES |
N([H])([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])[H]
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| InChi Key |
SSJXIUAHEKJCMH-WDSKDSINSA-N
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| InChi Code |
InChI=1S/C6H14N2/c7-5-3-1-2-4-6(5)8/h5-6H,1-4,7-8H2/t5-,6-/m0/s1
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| Chemical Name |
(1S,2S)-cyclohexane-1,2-diamine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.7573 mL | 43.7867 mL | 87.5733 mL | |
| 5 mM | 1.7515 mL | 8.7573 mL | 17.5147 mL | |
| 10 mM | 0.8757 mL | 4.3787 mL | 8.7573 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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