| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
N-Feruloylserotonin does not have a defined biological target. It exhibits antioxidant activity by scavenging free radicals and may have anti-inflammatory and neuroprotective effects. It may interact with serotonin receptors or other signaling pathways due to its serotonin moiety. It is a natural product with a serotonin-ferulic acid conjugate structure.
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|---|---|
| ln Vitro |
In vitro, N-feruloylserotonin exhibits antioxidant activity by scavenging free radicals. It may also show anti-inflammatory activity by inhibiting the production of pro-inflammatory mediators. It has been studied for its neuroprotective effects in neuronal cell cultures. It is used in research on oxidative stress and inflammation.
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| ln Vivo |
N-Feruloylserotonin is not a pharmacologically approved drug. It is a natural product and research compound with antioxidant, anti-inflammatory, and neuroprotective activities. It has not been evaluated in clinical trials.
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| Enzyme Assay |
In vitro assays for N-feruloylserotonin typically involve antioxidant and anti-inflammatory activity measurements. A standard protocol for antioxidant activity involves incubating the compound with DPPH or ABTS radicals and measuring the reduction in absorbance. For anti-inflammatory activity, cells are treated with the compound and stimulated with LPS, and cytokine production is measured.
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| Cell Assay |
In vitro cell culture experiments with N-feruloylserotonin typically involve neuronal cells or immune cells. Cells are cultured in appropriate media and treated with the compound at concentrations ranging from 1-100 µM for 24 hours. Antioxidant and anti-inflammatory markers are measured.
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| Animal Protocol |
In vivo animal studies with N-feruloylserotonin are not well documented. It is used primarily as a research compound.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of N-feruloylserotonin are not characterized, as it is not a drug substance. The compound is not intended for human exposure.
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| Toxicity/Toxicokinetics |
N-Feruloylserotonin may cause skin and eye irritation. Standard laboratory safety precautions should be followed when handling this compound, including the use of gloves, safety glasses, and working in a fume hood.
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| References | |
| Additional Infomation |
N-Feruloylserotonin is a hydroxyindole compound and an N-feruloyl derivative of serotonin. It is a plant metabolite. It belongs to the hydroxyindole, cinnamamide, phenol, aromatic ether, and secondary carboxamide classes. Its function is related to ferulic acid. It has been reported that thymol is present in Amberboa moschata, Centaurea arenaria, and other organisms with relevant data.
N-Feruloylserotonin is a natural product with antioxidant, anti-inflammatory, and neuroprotective activities. It has not undergone clinical trials and is not approved as a pharmaceutical. |
| Molecular Formula |
C20H20N2O4
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|---|---|
| Molecular Weight |
352.38
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| Exact Mass |
352.142
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| CAS # |
68573-23-9
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| PubChem CID |
5969616
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| Appearance |
White to off-white solid
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| Density |
1.338g/cm3
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| Boiling Point |
705.6ºC at 760 mmHg
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| Melting Point |
110-114 °C
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| Flash Point |
380.5ºC
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| Index of Refraction |
1.703
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| LogP |
3.35
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
26
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| Complexity |
498
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| Defined Atom Stereocenter Count |
0
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| SMILES |
OC1=CC=C2C(C(CCNC(=O)/C=C/C3C=CC(O)=C(OC)C=3)=CN2)=C1
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| InChi Key |
WGHKJYWENWLOMY-XVNBXDOJSA-N
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| InChi Code |
InChI=1S/C20H20N2O4/c1-26-19-10-13(2-6-18(19)24)3-7-20(25)21-9-8-14-12-22-17-5-4-15(23)11-16(14)17/h2-7,10-12,22-24H,8-9H2,1H3,(H,21,25)/b7-3+
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| Chemical Name |
(E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide
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| Synonyms |
(E/Z)-Moschamine; N-Feruloylserotonin
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (283.78 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8378 mL | 14.1892 mL | 28.3785 mL | |
| 5 mM | 0.5676 mL | 2.8378 mL | 5.6757 mL | |
| 10 mM | 0.2838 mL | 1.4189 mL | 2.8378 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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