| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Adamantane does not have a single defined biological target but is the structural backbone of numerous compounds. Adamantane derivatives have been used as antiviral agents, particularly against influenza A and HIV. Amantadine and rimantadine are well-known adamantane-based antivirals that target the M2 ion channel of the influenza virus. Adamantane has also shown antitumor activity.
|
|---|---|
| ln Vitro |
In vitro, adamantane is used as a structural scaffold for drug design and as a membrane anchor. It can be incorporated into liposomes for drug delivery research. Adamantane derivatives have shown antiviral activity against influenza A virus. It has potent antitumor activity and antiviral resistance.
|
| ln Vivo |
Adamantane is not a pharmacologically approved drug itself, but its derivatives, such as amantadine, are used to treat influenza A virus infections. Adamantane has been used to treat many human pathogens, including viruses, fungi, and bacteria. It is used in research on surface recognition and drug delivery.
|
| Enzyme Assay |
In vitro assays for adamantane focus on its physicochemical properties and use as a scaffold. Standard characterization includes nuclear magnetic resonance (¹H NMR, ¹³C NMR) and mass spectrometry. For membrane studies, adamantane is incorporated into lipid bilayers or liposomes, and its effects on membrane properties are studied using biophysical techniques.
|
| Cell Assay |
In vitro cell culture experiments with adamantane are not standard, as it is primarily a scaffold. When studying its derivatives, those compounds may be tested in cell culture.
|
| Animal Protocol |
In vivo animal studies are not conducted with adamantane itself. Its derivatives are studied in animal models of viral infection.
|
| ADME/Pharmacokinetics |
Pharmacokinetic properties of adamantane are not characterized, as it is not a drug substance. The compound is not intended for human exposure.
|
| Toxicity/Toxicokinetics |
Adamantane may cause skin and eye irritation. Standard laboratory safety precautions should be followed when handling this compound, including the use of gloves, safety glasses, and working in a fume hood.
|
| References | |
| Additional Infomation |
Adamantane is an adamantane compound, belonging to the polycyclic alkanes. Adamantane has been reported in guava (Psidium guajava), and relevant data are available. Adamantane is a mineral. It is a tricyclic bridged hydrocarbon.
Adamantane is a polycyclic cage molecule that serves as the structural backbone of numerous compounds, including antiviral drugs. It is used in research on surface recognition and drug delivery. It has not undergone clinical trials and is not approved as a pharmaceutical. |
| Molecular Formula |
C10H16
|
|---|---|
| Molecular Weight |
136.23
|
| Exact Mass |
136.125
|
| CAS # |
281-23-2
|
| Related CAS # |
Adamantane-d16; 30470-60-1
|
| PubChem CID |
9238
|
| Appearance |
White to off-white solid
|
| Density |
1.0±0.1 g/cm3
|
| Boiling Point |
187.1±7.0 °C at 760 mmHg
|
| Melting Point |
209-212 °C (subl.)(lit.)
|
| Flash Point |
48.9±11.7 °C
|
| Vapour Pressure |
0.9±0.2 mmHg at 25°C
|
| Index of Refraction |
1.517
|
| LogP |
4.22
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
0
|
| Rotatable Bond Count |
0
|
| Heavy Atom Count |
10
|
| Complexity |
75.1
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
C12CC3CC(C2)CC(C3)C1
|
| InChi Key |
RILYTVJVMAKLC-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C10H16/c1-7-2-9-4-8(1)5-10(3-7)6-9/h7-10H,1-6H2
|
| Chemical Name |
adamantane
|
| Synonyms |
Adamantane
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 2 mg/mL (14.68 mM)
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.3405 mL | 36.7026 mL | 73.4053 mL | |
| 5 mM | 1.4681 mL | 7.3405 mL | 14.6811 mL | |
| 10 mM | 0.7341 mL | 3.6703 mL | 7.3405 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
|
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
