| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
The primary target of dopamine-d4 hydrochloride is the Dopamine D4 receptor (D4R), a G protein-coupled receptor member of the D2-like subfamily of dopamine receptors. These receptors play important roles in cognition, attention, and decision-making. The compound may also interact with other dopamine receptor subtypes and adrenergic receptors. As a deuterated internal standard, dopamine-d4 hydrochloride is not typically evaluated for intrinsic biological activity, but it retains the pharmacological properties of dopamine.
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| ln Vitro |
Drug compounds have included stable heavy isotopes of carbon, hydrogen, and other elements, mostly as quantitative tracers while the drugs were being developed. Because deuteration may have an effect on a drug's pharmacokinetics and metabolic properties, it is a cause for concern [1].
Dopamine-d4 hydrochloride is an analytical standard and is not evaluated for intrinsic biological activity. It retains the pharmacological properties of dopamine but is used analytically rather than therapeutically. Its isotopic labeling does not significantly alter receptor binding affinity. The compound's primary utility is in analytical chemistry rather than pharmacological evaluation. |
| ln Vivo |
No in vivo activity is evaluated for this compound as a therapeutic agent. It is used as a quantitative tracer in drug development and neurochemical research to study dopamine metabolism and pharmacokinetics. The compound is used as an internal standard for the quantification of dopamine in biological samples.
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| Enzyme Assay |
Not applicable for this compound's primary use as an analytical standard. Receptor binding studies may be performed using dopamine-d4 as a tracer in competitive binding assays to quantify dopamine receptor occupancy, but these are analytical rather than pharmacological applications. The compound is used as an internal standard in mass spectrometry.
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| Cell Assay |
Not applicable; no cell-based assays are performed with dopamine-d4 hydrochloride as a test compound. It may be used as an internal standard in cell culture experiments where dopamine or its metabolites are being quantified by mass spectrometry.
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| Animal Protocol |
Not applicable; dopamine-d4 hydrochloride is not administered to animals as a therapeutic agent. It may be used in pharmacokinetic studies as a tracer to quantify endogenous dopamine levels or to study dopamine metabolism.
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| ADME/Pharmacokinetics |
Deuteration may affect the pharmacokinetic and metabolic profiles of drugs, which is a consideration in drug development. As an analytical standard, dopamine-d4 is used to study dopamine's metabolic pathways and pharmacokinetics with precise quantification. No specific PK data are available for this compound.
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| Toxicity/Toxicokinetics |
Dopamine-d4 hydrochloride is a labeled compound intended for research use only. No specific toxicity data have been reported, but as a deuterated analog of dopamine, it is expected to have a similar safety profile to dopamine hydrochloride. Standard laboratory safety precautions should be followed. The compound is a certified reference material.
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| References | |
| Additional Infomation |
Dopamine-d4 hydrochloride is not an approved drug; it is exclusively a research tool for analytical chemistry and neuropharmacology. Its value lies in enabling precise quantification of dopamine in biological samples, supporting research on neurodegenerative diseases, neuropharmacology, and receptor binding assays. Stable isotope labeling ensures reliable analytical results for studying dopamine metabolism and neurochemical interactions. The compound is used as a certified reference material for diagnostic testing and clinical chemistry.
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| Molecular Formula |
C8H8D4CLNO2
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|---|---|
| Molecular Weight |
193.66
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| Exact Mass |
193.081
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| CAS # |
203633-19-6
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| PubChem CID |
45039112
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| Appearance |
White to off-white solid powder
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| Melting Point |
241ºC(dec)
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| Flash Point |
11℃
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| LogP |
2.101
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
12
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| Complexity |
119
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| Defined Atom Stereocenter Count |
0
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| SMILES |
[2H]C([2H])(C1=CC(=C(C=C1)O)O)C([2H])([2H])N.Cl
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| InChi Key |
CTENFNNZBMHDDG-URZLSVTISA-N
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| InChi Code |
InChI=1S/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H/i3D2,4D2;
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| Chemical Name |
4-(2-amino-1,1,2,2-tetradeuterioethyl)benzene-1,2-diol;hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.1637 mL | 25.8184 mL | 51.6369 mL | |
| 5 mM | 1.0327 mL | 5.1637 mL | 10.3274 mL | |
| 10 mM | 0.5164 mL | 2.5818 mL | 5.1637 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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