| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
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| Other Sizes |
| Targets |
As a deuterated solvent and NMR reagent, Ethylene glycol-(OD)2 does not have a specific biological target. Its primary function is as an analytical tool for studying molecular interactions and reaction mechanisms through isotopic labeling.
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|---|---|
| ln Vitro |
Drug compounds have included stable heavy isotopes of carbon, hydrogen, and other elements, mostly as quantitative tracers while the drugs were being developed. Because deuteration may have an effect on a drug's pharmacokinetics and metabolic properties, it is a cause for concern [1].
The compound is not evaluated for traditional in vitro biological activity. Its "activity" is physicochemical, enabling precise monitoring of hydrogen bonding, solvent effects, and deuterium exchange in various experimental systems. |
| ln Vivo |
No in vivo activity is applicable for Ethylene glycol-(OD)2, as it is not a therapeutic agent. Its use is confined to the laboratory for analytical chemistry, NMR spectroscopy, and materials science research. The compound is not administered to living organisms for any biological effect.
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| Enzyme Assay |
The binding of Ethylene glycol-(OD)2 is not assessed through biological receptor assays. Its utility lies in its chemical properties as a deuterated solvent. The compound's purity (≥95%) and isotopic enrichment are typically verified by NMR spectroscopy and mass spectrometry.
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| Cell Assay |
Ethylene glycol-(OD)2 is not used in standard cell culture for pharmacological studies. It is a chemical reagent used in analytical and materials science applications. Researchers focus on its physicochemical properties, such as density, boiling point, and isotopic purity, rather than any cellular effects.
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| Animal Protocol |
Animal studies are not conducted with Ethylene glycol-(OD)2, as it is a research reagent. Its purpose is to serve as an analytical standard or deuterated solvent in laboratory experiments. The compound is never administered to animals for therapeutic or investigative purposes.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties are not relevant for Ethylene glycol-(OD)2, as it is not a therapeutic agent. Its chemical properties include a molecular weight of 64.08 g/mol, density of 1.148 g/mL at 25 °C, boiling point of 196-198 °C, and melting point of -13 °C. It is slightly soluble in water and is hygroscopic. The compound should be stored at -20°C and protected from moisture.
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| Toxicity/Toxicokinetics |
Based on safety data, Ethylene glycol-(OD)2 is classified with hazard symbol Xn (Harmful) and risk category R22 (Harmful if swallowed). It is classified under WGK Germany 3 (highly hazardous to water) and storage class 10 (flammable liquids). The compound is also classified for Acute Toxicity Category 4 (Oral) and Specific Target Organ Toxicity - Repeated Exposure Category 2.
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| References | |
| Additional Infomation |
Ethylene glycol-(OD)2 is a research-grade compound used in NMR spectroscopy, analytical chemistry, and materials science. Its deuterium labeling allows for the precise study of hydrogen bonding, solvent effects, and reaction mechanisms. The compound is not approved for therapeutic use and is strictly for laboratory research. It is available as a high-purity chemical reagent (≥95%) from various commercial suppliers.
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| Molecular Formula |
C2H4D2O2
|
|---|---|
| Molecular Weight |
64.08
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| Exact Mass |
64.049
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| CAS # |
2219-52-5
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| PubChem CID |
10986148
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| Appearance |
Colorless to light yellow liquid
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
197.5±0.0 °C at 760 mmHg
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| Melting Point |
-13ºC(lit.)
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| Flash Point |
108.2±13.0 °C
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| Vapour Pressure |
0.1±0.8 mmHg at 25°C
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| Index of Refraction |
1.422
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| LogP |
-1.69
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
4
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| Complexity |
6
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| Defined Atom Stereocenter Count |
0
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| SMILES |
[2H]OCCO[2H]
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| InChi Key |
LYCAIKOWRPUZTN-NMQOAUCRSA-N
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| InChi Code |
InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2/i3D,4D
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| Chemical Name |
1,2-dideuteriooxyethane
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 15.6055 mL | 78.0275 mL | 156.0549 mL | |
| 5 mM | 3.1211 mL | 15.6055 mL | 31.2110 mL | |
| 10 mM | 1.5605 mL | 7.8027 mL | 15.6055 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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