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| Other Sizes |
| Targets |
(-)-Terpinen-4-ol does not have a single well-defined biological target. As a monoterpene alcohol, it may interact with multiple cellular components, including ion channels and receptors. Its arrhythmogenic activity suggests it may affect cardiac ion channels, while its anticonvulsant activity indicates potential modulation of central nervous system targets. The compound's biological effects are likely mediated through multiple mechanisms.
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| ln Vitro |
In vitro, (-)-Terpinen-4-ol induces extrasystoles in isolated rat left atria when used at a concentration of 100 µM. This demonstrates its arrhythmogenic activity. Its anticonvulsant activity can be assessed in neuronal cell cultures by measuring its ability to modulate neuronal excitability or to protect against seizure-like activity. The compound's effects on ion channels and neurotransmitter systems can be evaluated.
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| ln Vivo |
(-)-Terpinen-4-ol has been found to have arrhythmogenic and anticonvulsant activities in vivo. It can be studied in animal models of epilepsy to evaluate its anticonvulsant potential. Its arrhythmogenic effects can be assessed in cardiovascular models. However, specific in vivo study details are not extensively documented in general references.
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| Enzyme Assay |
As a monoterpene alcohol, (-)-Terpinen-4-ol is not typically subjected to standard enzyme or receptor binding assays. Its biological activity is assessed through functional assays, such as measuring its effects on cardiac tissue or neuronal activity. The compound's purity and identity are confirmed by analytical techniques such as GC and NMR spectroscopy.
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| Cell Assay |
(-)-Terpinen-4-ol is used in cell-based and tissue-based assays to evaluate its biological activities. Its arrhythmogenic activity can be assessed in isolated cardiac tissue preparations. Its anticonvulsant activity can be evaluated in neuronal cell cultures by measuring its effects on neuronal firing or seizure-like activity. The compound's effects on various cellular targets can be studied.
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| Animal Protocol |
The in vivo effects of (-)-Terpinen-4-ol can be studied in animal models of epilepsy and cardiac arrhythmias. The compound is administered to animals, and its effects on seizure susceptibility and cardiac function are assessed. However, specific animal study protocols are not detailed in general references. The compound is primarily used in research settings.
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| ADME/Pharmacokinetics |
(-)-Terpinen-4-ol has a molecular weight of 154.25 g/mol and a molecular formula of C10H18O. It is a liquid at room temperature with a flash point of 79°C and an optical rotation of -25±5° (neat). The compound has a purity of ≥95%. It is soluble in organic solvents. As a monoterpene, its pharmacokinetic properties would be characteristic of this class of compounds.
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| Toxicity/Toxicokinetics |
Toxicological data for (-)-Terpinen-4-ol are not extensively detailed, as it is a research compound. It is not intended for human or veterinary use. Standard laboratory safety precautions, including the use of personal protective equipment (PPE), should be followed when handling the compound. Its safety profile would be established through dedicated toxicology studies if it were to be developed further.
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| References | |
| Additional Infomation |
p-Meth-1-en-4-OL is a p-menthane monoterpene compound. It has been reported to be found in thyme (Thymus marschallianus), citrus (Citrus reticulata), and several other organisms with relevant data. See also: 4-terpineol, (+/-)- (Note moved here).
(-)-Terpinen-4-ol is a monoterpene alcohol that has been found in A. zerumbet and has arrhythmogenic and anticonvulsant activities. It induces extrasystoles in isolated rat left atria when used at a concentration of 100 µM. The compound can be extracted from Bark Beetle Polygraphus poligraphus. It is a research-grade compound not approved for clinical use. |
| Molecular Formula |
C10H18O
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|---|---|
| Molecular Weight |
154.25
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| Exact Mass |
154.136
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| CAS # |
20126-76-5
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| PubChem CID |
5325830
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| Appearance |
Colorless to light yellow liquid
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| Density |
0.933
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| Boiling Point |
212ºC
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| Flash Point |
90ºC
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| Vapour Pressure |
0.0478mmHg at 25°C
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| Index of Refraction |
1.476-1.482
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| LogP |
2.503
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
11
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| Complexity |
170
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| Defined Atom Stereocenter Count |
1
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| SMILES |
CC(C)[C@@]1(CC=C(C)CC1)O
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| InChi Key |
WRYLYDPHFGVWKC-JTQLQIEISA-N
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| InChi Code |
InChI=1S/C10H18O/c1-8(2)10(11)6-4-9(3)5-7-10/h4,8,11H,5-7H2,1-3H3/t10-/m0/s1
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| Chemical Name |
(1R)-4-methyl-1-propan-2-ylcyclohex-3-en-1-ol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.4830 mL | 32.4149 mL | 64.8298 mL | |
| 5 mM | 1.2966 mL | 6.4830 mL | 12.9660 mL | |
| 10 mM | 0.6483 mL | 3.2415 mL | 6.4830 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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