| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| Other Sizes |
| Targets |
Padmatin does not have a single well-defined biological target. As a flavonoid, it may interact with multiple cellular pathways and enzymes. Its biological effects are thought to be mediated through various mechanisms, including antioxidant, anti-inflammatory, and other activities. The compound is primarily studied for its potential pharmacological properties as a natural product.
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| ln Vitro |
In vitro, Padmatin exhibits the biological activities characteristic of flavonoids. Its antioxidant activity can be assessed by measuring its ability to scavenge free radicals in cell-free assays. Its anti-inflammatory activity can be evaluated by measuring the inhibition of pro-inflammatory mediators in cell culture. As a dihydroflavonol, it may also exhibit other biological activities.
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| ln Vivo |
Specific in vivo activity data for Padmatin are limited. As a component of the herbal preparation PADMA 28, it has been utilized in European traditional medicine since the 1960s for various medical conditions. However, comprehensive in vivo studies for the pure compound are not widely documented. Its potential therapeutic applications require further investigation in animal models.
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| Enzyme Assay |
As a natural product, Padmatin is not typically subjected to standard enzyme or receptor binding assays. Its biological activity is assessed through cell-based screening rather than through specific receptor binding studies. The compound's purity and identity are confirmed by analytical techniques such as HPLC and NMR spectroscopy. It is typically stored desiccated at -20°C.
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| Cell Assay |
Padmatin is used in cell-based assays to evaluate its potential biological activities. Cells are treated with varying concentrations of the compound, and various endpoints such as cell viability, antioxidant capacity, and inflammatory markers are measured. As a flavonoid, it may exhibit cytoprotective or anti-inflammatory effects in cultured cells.
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| Animal Protocol |
Specific in vivo animal studies for Padmatin are not well documented. As a research compound, it may be used in animal models to study its pharmacokinetics, toxicity, and potential therapeutic effects. However, comprehensive in vivo data are not available in general references. The compound is primarily used for in vitro research purposes.
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| ADME/Pharmacokinetics |
Padmatin has a molecular weight of 318.28 g/mol and a molecular formula of C16H14O7. It is also known as Blumeatin C or Taxifolin 7-methyl ether. The compound is typically stored desiccated at -20°C. It is soluble in DMSO and other organic solvents. As a flavonoid, its pharmacokinetic properties would be characteristic of this class of natural products.
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| Toxicity/Toxicokinetics |
Toxicological data for Padmatin are not extensively detailed, as it is a research compound. It is not intended for human or veterinary use. Standard laboratory safety precautions, including the use of personal protective equipment (PPE), should be followed when handling the compound. Its safety profile would be established through dedicated toxicology studies if it were to be developed further.
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| References | |
| Additional Infomation |
Padmatine has reportedly been found in cherry plums, hornwort, and other organisms for which data is available.
Padmatin is a naturally occurring dihydroflavonol isolated from the heartwood of Prunus puddum. It is also known as Blumeatin C or Taxifolin 7-methyl ether. The compound is classified as a flavonoid. Padmatin is also known as PADMA 28, a multi-component herbal preparation with origins in Tibetan medicine that has been utilized in Europe since the 1960s. It is a research-grade compound not approved for clinical use. |
| Molecular Formula |
C16H14O7
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|---|---|
| Molecular Weight |
318.28
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| Exact Mass |
318.073
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| CAS # |
80453-44-7
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| PubChem CID |
12313901
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| Appearance |
White to off-white solid
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| Density |
1.6±0.1 g/cm3
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| Boiling Point |
665.0±55.0 °C at 760 mmHg
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| Flash Point |
252.0±25.0 °C
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| Vapour Pressure |
0.0±2.1 mmHg at 25°C
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| Index of Refraction |
1.695
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| LogP |
2
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
23
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| Complexity |
442
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| Defined Atom Stereocenter Count |
2
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| SMILES |
O=C1[C@H](O)[C@@H](C2C=CC(O)=C(O)C=2)OC2C=C(C=C(C1=2)O)OC
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| InChi Key |
MRPJBTFHICBFNE-JKSUJKDBSA-N
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| InChi Code |
InChI=1S/C16H14O7/c1-22-8-5-11(19)13-12(6-8)23-16(15(21)14(13)20)7-2-3-9(17)10(18)4-7/h2-6,15-19,21H,1H3/t15-,16+/m0/s1
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| Chemical Name |
(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-2,3-dihydrochromen-4-one
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| Synonyms |
Padmatin
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1419 mL | 15.7094 mL | 31.4189 mL | |
| 5 mM | 0.6284 mL | 3.1419 mL | 6.2838 mL | |
| 10 mM | 0.3142 mL | 1.5709 mL | 3.1419 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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