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| Other Sizes |
| Targets |
(1R,2R)-1-Aminoindan-2-ol does not have a specific biological target. It is the inactive isomer of (1S,2R)-1-Aminoindan-2-ol and is used primarily as a chemical reagent and experimental control. Its value lies in its chemical properties as a chiral building block for organic synthesis rather than in any direct biological activity. The compound is not intended to interact with biological targets in a pharmacologically relevant manner.
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| ln Vitro |
(1R,2R)-1-Aminoindan-2-ol itself is not evaluated for in vitro biological activity, as it serves as an inactive control compound. Its "activity" is chemical, referring to its utility as a chiral auxiliary and synthetic intermediate. The compound is used in organic synthesis to prepare indene-based chiral auxiliaries for asymmetric aldol reactions and oxazoline-alcohol ligands. No pharmacological in vitro activity is associated with this compound.
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| ln Vivo |
(1R,2R)-1-Aminoindan-2-ol is not administered as a therapeutic agent in vivo. Its primary applications are in organic synthesis and as an experimental control. It is not used in animal models as an active treatment for any disease indication. The compound is strictly a laboratory reagent for chemical and biochemical research.
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| Enzyme Assay |
As a chiral chemical reagent, (1R,2R)-1-Aminoindan-2-ol is not subjected to typical enzyme or receptor binding assays. Its performance is assessed by its chemical purity and optical purity, which are confirmed by techniques such as HPLC, NMR, and polarimetry. The compound is used as a starting material in the synthesis of chiral auxiliaries and ligands. Its reactivity and selectivity in chemical reactions are the primary measures of its utility.
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| Cell Assay |
(1R,2R)-1-Aminoindan-2-ol is not used in standard cell culture for pharmacological studies. It is a chemical reagent used in organic synthesis to prepare compounds that may later be tested in biological systems. The compound itself is not added to cell culture media for any biological effect. Its applications are strictly chemical, not biological.
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| Animal Protocol |
Animal studies are not conducted with (1R,2R)-1-Aminoindan-2-ol as an active compound. Its purpose is to serve as a reagent for the synthesis of compounds that may later be tested in vivo. The compound is never administered to animals for therapeutic or investigative purposes. It is a chemical intermediate, not a drug candidate.
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| ADME/Pharmacokinetics |
(1R,2R)-1-Aminoindan-2-ol has a molecular weight of 149.18 g/mol and a molecular formula of C9H11NO. It is a chiral, optically active compound with a standard purity of 98%. The compound is typically stored at room temperature and is soluble in organic solvents. It is available as a solid powder. Its physical and chemical properties are well-characterized for use in organic synthesis.
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| Toxicity/Toxicokinetics |
Toxicological data for (1R,2R)-1-Aminoindan-2-ol are not extensively detailed, as it is a research compound. It is not intended for human or veterinary use. Standard laboratory safety precautions, including the use of personal protective equipment (PPE), should be followed when handling the compound. Its safety profile would be established through dedicated toxicology studies if it were to be developed further.
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| References | |
| Additional Infomation |
(1R,2R)-1-Aminoindan-2-ol is the inactive isomer of (1S,2R)-1-Aminoindan-2-ol and is used as an experimental control. It can be used as a starting material to prepare an indene-based chiral auxiliary for aldol reactions and in the synthesis of oxazoline-alcohol ligands. The compound is a biochemical reagent used in life science related research. It is not approved for therapeutic use and is strictly for laboratory research.
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| Molecular Formula |
C9H11NO
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|---|---|
| Molecular Weight |
149.19
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| Exact Mass |
149.084
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| CAS # |
163061-73-2
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| Related CAS # |
(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol;126456-43-7
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| PubChem CID |
6931154
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| Appearance |
White to off-white solid powder
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| Density |
1.212 g/cm3
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| Boiling Point |
290ºC at 760 mmHg
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| Melting Point |
142-146ºC
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| Vapour Pressure |
0.000978mmHg at 25°C
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| Index of Refraction |
1.626
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| LogP |
1.303
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
11
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| Complexity |
149
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| Defined Atom Stereocenter Count |
2
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| SMILES |
C1[C@H]([C@@H](C2=CC=CC=C21)N)O
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| InChi Key |
LOPKSXMQWBYUOI-RKDXNWHRSA-N
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| InChi Code |
InChI=1S/C9H11NO/c10-9-7-4-2-1-3-6(7)5-8(9)11/h1-4,8-9,11H,5,10H2/t8-,9-/m1/s1
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| Chemical Name |
(1R,2R)-1-amino-2,3-dihydro-1H-inden-2-ol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.7029 mL | 33.5143 mL | 67.0286 mL | |
| 5 mM | 1.3406 mL | 6.7029 mL | 13.4057 mL | |
| 10 mM | 0.6703 mL | 3.3514 mL | 6.7029 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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