| Size | Price | Stock | Qty |
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| 250mg |
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| 500mg |
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| Targets |
2-Hydroxymethyl-5-hydroxypyridine is a natural product isolated from S. lychnophora seeds. As a pyridine derivative with both hydroxymethyl and hydroxyl substituents, it may interact with various biological targets. The compound's natural occurrence suggests it may have ecological or physiological functions in the plant. Its use as an analytical standard indicates it is used for identification and quantification purposes. Further research is needed to identify its specific molecular targets and biological activities. The compound's structure suggests potential for hydrogen bonding and metal chelation interactions.
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| ln Vitro |
In vitro studies of 2-Hydroxymethyl-5-hydroxypyridine have focused on its isolation and characterization from S. lychnophora seeds. The compound has been identified as a natural product with a purity of 99.67%. Its chemical structure has been confirmed using analytical methods. The compound is used as an analytical standard for research and analytical applications. These in vitro studies provide foundational data for understanding the compound's properties and its potential applications in natural product research and analytical chemistry. Further biological studies are needed to characterize its activities.
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| ln Vivo |
In vivo studies of 2-Hydroxymethyl-5-hydroxypyridine are limited, as the compound is primarily used as a research chemical and analytical standard. Its isolation from S. lychnophora seeds suggests it may have ecological or physiological functions in the plant. As a natural product, it may be metabolized through standard xenobiotic pathways if consumed. However, comprehensive in vivo studies specifically targeting this compound are not well documented in the available literature. Further research is needed to fully characterize its in vivo pharmacokinetic and pharmacodynamic properties.
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| Enzyme Assay |
In vitro enzyme and receptor binding assays for 2-Hydroxymethyl-5-hydroxypyridine are not well documented, as the compound is primarily used as an analytical standard and natural product. Its purity and identity are assessed using analytical chemistry methods such as high-performance liquid chromatography, nuclear magnetic resonance spectroscopy, and mass spectrometry. The compound's solubility and stability are characterized for research applications. For potential biological activities, relevant assays would need to be developed based on its structural features. All assays are performed with appropriate controls and standardized protocols to ensure reproducibility of results.
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| Cell Assay |
In vitro cell-based assays for 2-Hydroxymethyl-5-hydroxypyridine are limited, as the compound is primarily used as an analytical standard and natural product. Its effects on cells would need to be evaluated in the context of its natural occurrence. Cells could be treated with varying concentrations of the compound and cell viability assessed using MTT or similar colorimetric assays. Potential biological activities such as antioxidant, antimicrobial, or cytotoxic effects could be evaluated. However, comprehensive cell-based studies specifically targeting this compound are not well documented in the available literature.
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| Animal Protocol |
In vivo animal experiments for 2-Hydroxymethyl-5-hydroxypyridine are not well documented, as the compound is primarily used as a research chemical and analytical standard. For potential pharmacological studies, animals would be administered the compound and relevant parameters assessed. Parameters assessed would include body weight, organ weights, blood biochemistry, and histopathology. Control groups receiving vehicle alone would be included for comparison. All procedures would comply with institutional animal care and use committee guidelines. Comprehensive in vivo studies are not well documented in the available literature.
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| ADME/Pharmacokinetics |
The pharmacokinetic properties of 2-Hydroxymethyl-5-hydroxypyridine reflect its nature as a small pyridine derivative. It has a molecular weight of 125.13 and the molecular formula C6H7NO2. The compound has a purity of 99.67%. As a small hydrophilic molecule with both hydroxymethyl and hydroxyl groups, it is expected to be water-soluble. The compound is stored under appropriate conditions for research applications. Complete pharmacokinetic profiling including absorption, distribution, metabolism, excretion, half-life, and bioavailability would require further systematic studies using appropriate analytical methods such as high-performance liquid chromatography-mass spectrometry.
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| Toxicity/Toxicokinetics |
The toxicity profile of 2-Hydroxymethyl-5-hydroxypyridine has been evaluated in the context of its use as a research chemical. As a natural product isolated from S. lychnophora seeds, it is expected to have a favorable safety profile at research concentrations. Proper handling procedures including use of personal protective equipment are recommended when working with pure compound. The compound is not approved for human therapeutic use and is intended for research purposes only. Long-term toxicity studies would be needed to fully establish its safety profile for pharmaceutical applications. The compound's natural occurrence suggests it may be safe at low concentrations.
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| References | |
| Additional Infomation |
5-Hydroxy-2-pyridinemethanol is a hydroxypyridine. 6-(hydroxymethyl)pyridine-3-ol has been reportedly found in Codonopsis pilosula, and relevant data are available.
2-Hydroxymethyl-5-hydroxypyridine (CAS# 40222-77-3) is also known as 6-(hydroxymethyl)pyridin-3-ol. It has the molecular formula C6H7NO2 and a molecular weight of 125.13. The compound is isolated from the matured, ripened, and dried seeds of S. lychnophora. It has a purity of 99.67%. The compound is used as an analytical standard for research and analytical applications. The IUPAC name is 6-(hydroxymethyl)pyridin-3-ol. The compound is intended for research use only. |
| Molecular Formula |
C6H7NO2
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|---|---|
| Molecular Weight |
125.13
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| Exact Mass |
125.047
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| CAS # |
40222-77-3
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| PubChem CID |
419490
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| Appearance |
Yellow to brown solid
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
419.5±30.0 °C at 760 mmHg
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| Melting Point |
123-125ºC
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| Flash Point |
207.5±24.6 °C
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| Vapour Pressure |
0.0±1.0 mmHg at 25°C
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| Index of Refraction |
1.605
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| LogP |
-0.54
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
9
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| Complexity |
87.1
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O([H])C([H])([H])C1C([H])=C([H])C(=C([H])N=1)O[H]
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| InChi Key |
NESFDGDRYVANBC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H7NO2/c8-4-5-1-2-6(9)3-7-5/h1-3,8-9H,4H2
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| Chemical Name |
6-(hydroxymethyl)pyridin-3-ol
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| Synonyms |
2-Hydroxymethyl-5-hydroxypyridine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.9917 mL | 39.9584 mL | 79.9169 mL | |
| 5 mM | 1.5983 mL | 7.9917 mL | 15.9834 mL | |
| 10 mM | 0.7992 mL | 3.9958 mL | 7.9917 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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