| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
1,2-Diheptadecanoyl-sn-glycero-3-phosphorylcholine targets cellular membranes as a phospholipid component. As a derivative of phosphatidylcholine (PC), it is used to study membrane structure and function. The compound's two heptadecanoyl chains provide specific membrane properties for biophysical studies. It is used in biochemistry and cell biology research to investigate lipid bilayer properties, membrane protein interactions, and lipid signaling. The compound's targets are membrane-associated rather than specific biological receptors.
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| ln Vitro |
In vitro studies of 1,2-Diheptadecanoyl-sn-glycero-3-phosphorylcholine have focused on its role as a phospholipid for membrane studies. The compound is used as a model phospholipid in biophysical studies of lipid bilayers. Its membrane properties have been characterized. As a biologically active phospholipid compound and derivative of phosphatidylcholine, it is used to study membrane structure and function. These in vitro studies provide foundational data for understanding the compound's utility in membrane biology research.
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| ln Vivo |
In vivo studies of 1,2-Diheptadecanoyl-sn-glycero-3-phosphorylcholine are limited as the compound is primarily used as a research chemical for in vitro membrane studies. The compound is not intended for administration to living organisms for pharmacological evaluation. Its applications are limited to biochemistry and cell biology research. The compound is not approved for human therapeutic use and is intended for research purposes only.
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| Enzyme Assay |
In vitro membrane assays for 1,2-Diheptadecanoyl-sn-glycero-3-phosphorylcholine typically involve testing its properties as a phospholipid in model membranes. Liposomes or other membrane models are prepared with the compound and membrane properties are assessed using techniques such as fluorescence spectroscopy, differential scanning calorimetry, and microscopy. The compound's purity (99%) and identity are confirmed using analytical chemistry methods such as high-performance liquid chromatography and mass spectrometry.
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| Cell Assay |
In vitro cell-based assays for 1,2-Diheptadecanoyl-sn-glycero-3-phosphorylcholine involve culturing cells to evaluate its effects on membrane properties and cellular functions. Cells are treated with varying concentrations of the compound and membrane fluidity, permeability, and other properties are assessed. Cell viability is assessed using MTT or similar colorimetric assays. All experiments are performed in triplicate with appropriate controls to ensure statistical reliability.
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| Animal Protocol |
In vivo animal experiments for 1,2-Diheptadecanoyl-sn-glycero-3-phosphorylcholine are not applicable as the compound is primarily used as a research chemical for in vitro studies rather than as a therapeutic agent. The compound is not administered to animals for pharmacological evaluation. Its applications are limited to biochemistry and cell biology research. The compound is not intended for in vivo use.
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| ADME/Pharmacokinetics |
The pharmacokinetic properties of 1,2-Diheptadecanoyl-sn-glycero-3-phosphorylcholine are not applicable as the compound is a research chemical used for in vitro studies rather than a therapeutic agent. It has a molecular weight of 762.09 and the molecular formula C42H84NO8P. The compound has a purity of 99%. Its physicochemical properties including solubility and stability are characterized for its use as a research reagent.
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| Toxicity/Toxicokinetics |
The toxicity profile of 1,2-Diheptadecanoyl-sn-glycero-3-phosphorylcholine has been evaluated in the context of its use as a research chemical. As a phospholipid, it is expected to have low toxicity. The compound has a purity of 99%. Proper handling procedures including use of personal protective equipment are recommended when working with pure compound. The compound is not approved for human therapeutic use and is intended for research purposes only.
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| References | |
| Additional Infomation |
PC (17:0/17:0) is a phosphatidylcholine 34:0.
1,2-Diheptadecanoyl-sn-glycero-3-phosphorylcholine (CAS# 70897-27-7) is also known as DHPC. It has the molecular formula C42H84NO8P and a molecular weight of 762.09. The compound is a synthetic phospholipid and a biologically active derivative of phosphatidylcholine (PC). DHPC is commonly used in biochemistry and cell biology research. The compound has a purity of 99% and is intended for research use only. |
| Molecular Formula |
C42H84NO8P
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|---|---|
| Molecular Weight |
762.09
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| Exact Mass |
761.593
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| CAS # |
70897-27-7
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| PubChem CID |
24778784
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| Appearance |
White to off-white solid powder
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| LogP |
12.462
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
42
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| Heavy Atom Count |
52
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| Complexity |
857
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| Defined Atom Stereocenter Count |
1
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| SMILES |
CCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCC
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| InChi Key |
RTWAYAIMWLNAJW-RRHRGVEJSA-N
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| InChi Code |
InChI=1S/C42H84NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-41(44)48-38-40(39-50-52(46,47)49-37-36-43(3,4)5)51-42(45)35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h40H,6-39H2,1-5H3/t40-/m1/s1
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| Chemical Name |
[(2R)-2,3-di(heptadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.3122 mL | 6.5609 mL | 13.1218 mL | |
| 5 mM | 0.2624 mL | 1.3122 mL | 2.6244 mL | |
| 10 mM | 0.1312 mL | 0.6561 mL | 1.3122 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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