| Size | Price | Stock | Qty |
|---|---|---|---|
| 25g |
|
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| Other Sizes |
| Targets |
Thiol-containing enzymes and proteins.
|
|---|---|
| ln Vitro |
Dipentamethylenethiuram Tetrasulfide is a thiuram compound that can interact with thiol groups in proteins and enzymes. It is used as a vulcanization accelerator in the rubber industry. The compound may have antimicrobial and antifungal properties.
|
| ln Vivo |
In vivo studies of dipentamethylenethiuram tetrasulfide are limited. As a rubber accelerator, it is primarily used in industrial applications. The compound may have toxicological effects and should be handled with care.
|
| Enzyme Assay |
The compound's interaction with thiol groups can be studied using biochemical assays. Enzyme inhibition assays can be used to assess its effects on thiol-containing enzymes.
|
| Cell Assay |
Cell-based assays for dipentamethylenethiuram tetrasulfide are limited. Cytotoxicity can be assessed in various cell lines.
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| Animal Protocol |
In vivo studies for dipentamethylenethiuram tetrasulfide are primarily toxicological. Standard toxicology protocols would apply.
|
| ADME/Pharmacokinetics |
Dipentamethylenethiuram Tetrasulfide is a sulfur-containing compound used in industrial applications. It is soluble in organic solvents. Standard laboratory storage conditions apply.
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| Toxicity/Toxicokinetics |
Dipentamethylenethiuram Tetrasulfide may have toxicological effects and should be handled with appropriate safety precautions. It is not intended for human or animal use.
|
| References |
[1]. Mai, Guanshui, et al. Gradient self-lubricating rubber material and preparation method thereof. Patent CN112876756A.
|
| Additional Infomation |
Dipentamethylenethiuram Tetrasulfide is a thiuram compound used as a vulcanization accelerator in the rubber industry. It is for research and industrial use only.
|
| Molecular Formula |
C12H20N2S6
|
|---|---|
| Molecular Weight |
384.69
|
| Exact Mass |
383.995
|
| CAS # |
120-54-7
|
| PubChem CID |
61049
|
| Appearance |
White to off-white solid powder
|
| Density |
1.4±0.1 g/cm3
|
| Boiling Point |
510.1±33.0 °C at 760 mmHg
|
| Flash Point |
262.3±25.4 °C
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| Vapour Pressure |
0.0±1.3 mmHg at 25°C
|
| Index of Refraction |
1.730
|
| LogP |
5.5
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
6
|
| Rotatable Bond Count |
5
|
| Heavy Atom Count |
20
|
| Complexity |
294
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
S(C(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=S)SSSC(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=S
|
| InChi Key |
VNDRMZTXEFFQDR-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C12H20N2S6/c15-11(13-7-3-1-4-8-13)17-19-20-18-12(16)14-9-5-2-6-10-14/h1-10H2
|
| Chemical Name |
(piperidine-1-carbothioyltrisulfanyl) piperidine-1-carbodithioate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5995 mL | 12.9975 mL | 25.9950 mL | |
| 5 mM | 0.5199 mL | 2.5995 mL | 5.1990 mL | |
| 10 mM | 0.2599 mL | 1.2997 mL | 2.5995 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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