| Size | Price | Stock | Qty |
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| 10mg |
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| 50mg |
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| Other Sizes |
| Targets |
Serotonin receptors; tryptamine receptors. 5-PT (5-Propargyltryptamide) is a tryptamide derivative that may interact with serotonin receptors or other tryptamine targets. The propargyl group at the 5-position may confer unique pharmacological properties compared to other tryptamine derivatives. The compound's mechanism of action may involve binding to serotonin receptors or modulation of serotonin signaling. However, specific information about its target and mechanism is limited.
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| ln Vitro |
In vitro activity data for 5-PT are limited. As a tryptamide derivative, it may have biological activities related to serotonin receptor modulation. The compound's specific in vitro activities depend on the concentrations tested and the assay systems used. Further studies are needed to fully characterize its activity profile.
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| ln Vivo |
In vivo studies of 5-PT are limited. As a tryptamide derivative, it may have potential effects on serotonin signaling and related neurological functions. The compound may be evaluated in animal models of neurological or psychiatric disorders. Further studies are needed to characterize its specific in vivo activities, pharmacokinetic properties, and safety profile.
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| Enzyme Assay |
Non-cell-based assays for 5-PT include receptor binding assays using serotonin receptors or other relevant targets. Radioligand binding assays can be used to assess the compound's affinity for these receptors. Standard analytical methods including HPLC, NMR, and mass spectrometry are used for compound characterization and purity assessment.
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| Cell Assay |
Cell-based assays for 5-PT use various cell lines to assess its biological activities. Receptor activation can be assessed by measuring downstream signaling (e.g., calcium influx, cAMP modulation). Neuronal cell lines can be used to study effects on neuronal excitability and neurotransmitter release. Cytotoxicity is assessed using standard cell viability assays.
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| Animal Protocol |
In vivo studies of 5-PT are limited. Based on its structural similarity to tryptamine, potential animal models include: models of neurological or psychiatric disorders for evaluating effects on behavior and neurological function. Standard protocols for these models involve administration of the compound followed by measurement of relevant endpoints.
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| ADME/Pharmacokinetics |
5-PT (5-Propargyltryptamide) has a molecular formula of C₁₄H₁₄N₂O and a molecular weight of approximately 226.27 g/mol. The CAS number is 92085-05-7. It is a synthetic tryptamide derivative with a propargyl group at the 5-position of the indole ring. The compound is structurally related to tryptamine and other indole alkaloids. It should be stored under recommended conditions. It is intended for research use only.
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| Toxicity/Toxicokinetics |
Specific toxicity data for 5-PT are limited. As a tryptamide derivative, it may have biological activity at certain concentrations. Standard laboratory safety practices should be followed when handling this compound, including the use of personal protective equipment. It is intended for research use only.
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| References |
[1]. Lin JC, et al. Characterization of protein serotonylation via bioorthogonal labeling and enrichment. J Proteome Res. 2014 Aug 1;13(8):3523-9.
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| Additional Infomation |
5-PT (5-Propargyltryptamide) is a synthetic tryptamide derivative with a propargyl group at the 5-position of the indole ring. Tryptamine derivatives are a class of compounds known for their diverse biological activities, including interactions with serotonin receptors and other neurotransmitter systems. The compound is used as a research tool for studying tryptamine pharmacology and as a building block for the synthesis of more complex indole-containing compounds. It is for research use only.
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| Molecular Formula |
C13H14N2O
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|---|---|
| Molecular Weight |
214.26
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| Exact Mass |
214.11
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| CAS # |
92085-05-7
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| Related CAS # |
5-PT formic;2906227-87-8
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| PubChem CID |
86254606
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| Appearance |
Typically exists as solid at room temperature
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| LogP |
0.7
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
16
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| Complexity |
270
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C#CCOC1=CC2=C(C=C1)NC=C2CCN
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| InChi Key |
DTWYQMFAHVECJC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C13H14N2O/c1-2-7-16-11-3-4-13-12(8-11)10(5-6-14)9-15-13/h1,3-4,8-9,15H,5-7,14H2
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| Chemical Name |
2-(5-prop-2-ynoxy-1H-indol-3-yl)ethanamine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.6672 mL | 23.3361 mL | 46.6723 mL | |
| 5 mM | 0.9334 mL | 4.6672 mL | 9.3345 mL | |
| 10 mM | 0.4667 mL | 2.3336 mL | 4.6672 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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