| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| Other Sizes |
| Toxicity/Toxicokinetics |
Effects During Pregnancy and Lactation
◉ Overview of Medication Use During Lactation No studies have been conducted on fluocinolone acetonide during lactation. Since only large-area application of potent corticosteroids is likely to have systemic effects on the mother, short-term topical application of corticosteroids is unlikely to pose a risk to the breastfeeding infant through breast milk. However, it is advisable to use the least potent medication on the smallest possible area of skin. It is especially important to ensure that the infant's skin does not come into direct contact with the treated area. Only low-potency corticosteroids should be used on the nipple or areola, where the infant may ingest the medication directly through the skin. Only water-soluble creams or gels should be applied to the breast, as ointments may expose the infant to high concentrations of mineral oil through licking. If topical corticosteroids are applied to the breast or nipple area, they should be thoroughly wiped off before breastfeeding. The risk to the breastfeeding infant from the mother's use of fluocinolone acetonide-containing ear drops or eye plugs is negligible. Currently, experts generally agree that fluocinolone acetonide implants can be used to treat diabetic macular edema in breastfeeding mothers. ◉ Effects on Breastfed Infants A mother applied a topical corticosteroid (isofluprednisolone acetate) with high mineralocorticoid activity to her nipples, resulting in QT interval prolongation, Cushing's syndrome-like symptoms, severe hypertension, growth retardation, and electrolyte imbalance in her 2-month-old breastfed infant. The mother had been using the cream to treat nipple pain since the infant's birth. ◉ Effects on Lactation and Breast Milk As of the revision date, no relevant published information was found. |
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| References |
[1]. Y Aizawa, et al. Effect of difluprednate on adrenocortical and gonadal function]. Nihon Yakurigaku Zasshi. 1984 Dec;84(6):553-61.
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| Additional Infomation |
Fluocinolone acetonide is a fluorinated steroid. Fluocinolone acetonide has been used in trials for the treatment and prevention of Candida albicans infections, oral lichen planus, macular degeneration, and choroidal neovascularization. Fluocinolone acetonide is a synthetic glucocorticoid with anti-inflammatory and antipruritic effects. Fluocinolone acetonide binds to glucocorticoid receptors, followed by translocation of the ligand-receptor complex to the nucleus, activating transcription of genes containing glucocorticoid response elements. Lipocorticin-1 is one of the factors induced by fluocinolone acetonide; it interacts with and inhibits the activity of cytoplasmic phospholipase 2α, thereby preventing the translocation of phospholipase to the perinuclear membrane, which in turn prevents the release of arachidonic acid and its conversion into inflammatory prostaglandins. Furthermore, MAPK phosphatase 1 is induced, thereby preventing the triggering of the MAPK cascade, which in turn inhibits Jun N-terminal kinase and c-Jun-mediated pro-inflammatory effects. Finally, fluocinolone acetonide directly binds to and inhibits nuclear factor κB, thereby inhibiting the transcription of cyclooxygenase 2 and subsequent prostaglandin synthesis.
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| Molecular Formula |
C21H26F2O6
|
|---|---|
| Molecular Weight |
412.42
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| Exact Mass |
412.17
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| CAS # |
807-38-5
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| PubChem CID |
91488
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| Appearance |
White to off-white solid powder
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| Density |
1.45g/cm3
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| Boiling Point |
589ºC at 760 mmHg
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| Flash Point |
310ºC
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| Index of Refraction |
1.603
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| LogP |
0.568
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
29
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| Complexity |
841
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| Defined Atom Stereocenter Count |
9
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| SMILES |
F[C@@]12[C@]3(C=CC(C=C3[C@@H](F)C[C@H]1[C@@H]1C[C@@H](O)[C@](O)(C(=O)CO)[C@]1(C[C@@H]2O)C)=O)C
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| InChi Key |
UUOUOERPONYGOS-CLCRDYEYSA-N
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| InChi Code |
InChI=1S/C21H26F2O6/c1-18-4-3-10(25)5-13(18)14(22)6-12-11-7-15(26)21(29,17(28)9-24)19(11,2)8-16(27)20(12,18)23/h3-5,11-12,14-16,24,26-27,29H,6-9H2,1-2H3/t11-,12-,14-,15+,16-,18-,19-,20-,21-/m0/s1
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| Chemical Name |
(6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,9-difluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 31.25 mg/mL (75.77 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4247 mL | 12.1236 mL | 24.2471 mL | |
| 5 mM | 0.4849 mL | 2.4247 mL | 4.8494 mL | |
| 10 mM | 0.2425 mL | 1.2124 mL | 2.4247 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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