| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Not applicable (chemical reagent). Chloropyrazine is a chemical reagent used in organic synthesis and does not have a defined pharmacological target. It is used as a building block for the synthesis of bioactive compounds rather than as a pharmacologically active agent itself.
|
|---|---|
| ln Vitro |
Chloropyrazine is a chemical reagent used in organic synthesis and does not exhibit direct in vitro biological activity in pharmacological assays. It is used to synthesize compounds with biological activities, including antimalarial and β-lactamase inhibitory activities.
|
| ln Vivo |
In vivo studies of chloropyrazine are not applicable as the compound is a chemical reagent rather than a pharmacologically active compound. It is used in organic synthesis to produce bioactive compounds that may be evaluated in vivo.
|
| Enzyme Assay |
Non-cell-based assays for chloropyrazine are analytical in nature. Standard methods including GC, HPLC, NMR, and mass spectrometry are used for identification, quantification, and purity assessment. Physicochemical properties such as boiling point, density, and refractive index are determined using standard protocols.
|
| Cell Assay |
Cell-based assays for chloropyrazine are not commonly performed, as the compound is a chemical reagent rather than a pharmacologically active compound. Compounds synthesized using this reagent may be tested in cell-based assays.
|
| Animal Protocol |
In vivo animal studies for chloropyrazine are not applicable as the compound is a chemical reagent rather than a pharmacologically active compound.
|
| ADME/Pharmacokinetics |
Chloropyrazine has a molecular formula of C₄H₃ClN₂ and a molecular weight of 114.53 g/mol. It is a colorless or slightly yellow transparent liquid with a boiling point of 153-154°C and a density of 1.283 g/mL. The compound should be stored below +30°C. It is used as a reagent in organic synthesis.
|
| Toxicity/Toxicokinetics |
Specific toxicity data for chloropyrazine are limited. As a chemical reagent, it may cause irritation to the skin, eyes, and respiratory tract. Standard laboratory safety practices should be followed when handling this compound.
|
| References | |
| Additional Infomation |
2-Chloropyrazine is a type of pyrazine compound.
Chloropyrazine (2-Chloropyrazine) is a heterocyclic compound used as a reagent in organic synthesis. It is used in the synthesis of hetaryloxy benzoxaborole compounds with antimalarial activity and in the preparation of serine β-lactamase inhibitors. The compound is for research use only. |
| Molecular Formula |
C4H3CLN2
|
|---|---|
| Molecular Weight |
114.53
|
| Exact Mass |
113.998
|
| CAS # |
14508-49-7
|
| PubChem CID |
73277
|
| Appearance |
Colorless to light yellow liquid
|
| Density |
1.3±0.1 g/cm3
|
| Boiling Point |
155.3±20.0 °C at 760 mmHg
|
| Flash Point |
57.8±0.0 °C
|
| Vapour Pressure |
3.9±0.3 mmHg at 25°C
|
| Index of Refraction |
1.535
|
| LogP |
0.64
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
0
|
| Heavy Atom Count |
7
|
| Complexity |
57.7
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
ClC1C([H])=NC([H])=C([H])N=1
|
| InChi Key |
GELVZYOEQVJIRR-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C4H3ClN2/c5-4-3-6-1-2-7-4/h1-3H
|
| Chemical Name |
2-chloropyrazine
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (873.13 mM)
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.7313 mL | 43.6567 mL | 87.3134 mL | |
| 5 mM | 1.7463 mL | 8.7313 mL | 17.4627 mL | |
| 10 mM | 0.8731 mL | 4.3657 mL | 8.7313 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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