| Size | Price | Stock | Qty |
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| 10mg |
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| 50mg |
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| 100mg |
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| 500mg | |||
| 1g | |||
| Other Sizes |
| Targets |
Tetrachloroguaiacol targets renal xenobiotic elimination pathways, as it has been shown to inhibit renal excretion of xenobiotics. As a chlorinated phenol, it may interact with various cellular targets including transporters, enzymes, and membrane proteins. The compound's presence in wastewater and its formation from pentachlorophenol degradation make it an environmental contaminant of concern.
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| ln Vitro |
Renal xenobiotic removal is inhibited by tetrachloroguaiacol[1].
In vitro, Tetrachloroguaiacol inhibits renal xenobiotic elimination. The compound's effects on renal transport and excretion have been studied in cellular and tissue models. Its activity is concentration-dependent. Tetrachloroguaiacol is also studied as an environmental contaminant and its effects on biological systems are characterized. However, specific in vitro activity data are limited. |
| ln Vivo |
In vivo, Tetrachloroguaiacol is an environmental contaminant that can be detected in wastewater. Its effects on renal xenobiotic elimination have been observed in animal studies. The compound's presence in the environment and its potential toxicity to aquatic organisms and humans are concerns. However, detailed in vivo data are limited.
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| Enzyme Assay |
Non-cell-based assays for Tetrachloroguaiacol involve characterization of its chemical properties and environmental fate. The compound's structure is confirmed by NMR and MS. Its purity is determined by HPLC. The compound's chemical properties including molecular formula (C₇H₄Cl₄O₂) and molecular weight (261.92) are characterized. Its stability and degradation in environmental samples are studied.
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| Cell Assay |
Cellular assays for Tetrachloroguaiacol are performed using renal cell lines to study its effects on xenobiotic elimination. Cells are treated with the compound at various concentrations, and cellular responses are measured. Cell viability is measured by MTT assays. Transporter activity and xenobiotic efflux are measured. The compound's effects on cellular metabolism and signaling pathways may also be evaluated.
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| Animal Protocol |
In vivo experiments with Tetrachloroguaiacol are conducted in animal models to study its effects on renal function and xenobiotic elimination. Animals are treated with the compound, and renal clearance of xenobiotics is measured. The compound's toxicity and organ distribution may also be evaluated. However, detailed in vivo data are limited. The compound is primarily studied as an environmental contaminant.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Tetrachloroguaiacol have not been extensively characterized. As a chlorinated phenol with a molecular weight of 261.92, the compound is expected to have moderate lipophilicity and tissue distribution. Its absorption, distribution, metabolism, and excretion are not well-defined. The compound's environmental persistence is of greater concern than its pharmacokinetics.
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| Toxicity/Toxicokinetics |
The toxicity of Tetrachloroguaiacol is a concern as it is a chlorinated phenolic compound detected in wastewater. Chlorinated phenols can be toxic to aquatic organisms and may have adverse effects on human health. The compound has been shown to inhibit renal xenobiotic elimination, which may contribute to its toxicity. Comprehensive toxicological studies have been conducted for environmental risk assessment.
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| References | |
| Additional Infomation |
Tetrachlorocatechol methyl ether belongs to the methoxybenzene class and phenolic compounds. Tetrachloroguaiacol has been found in Mycena leaiana, and relevant data have been reported.
Tetrachloroguaiacol (CAS# 2539-17-5) is a major chlorinated phenol with the molecular formula C₇H₄Cl₄O₂ and a molecular weight of 261.92. It is also known as 2,3,4,5-tetrachloro-6-methoxyphenol. Tetrachloroguaiacol is produced during the chlorine bleaching process of wood pulp and is a product of pentachlorophenol degradation in fungal communities. It is detected in wastewater and inhibits renal xenobiotic elimination. As of current knowledge, Tetrachloroguaiacol is not approved as a therapeutic agent. |
| Molecular Formula |
C7H4CL4O2
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|---|---|
| Molecular Weight |
261.91746
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| Exact Mass |
259.896
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| CAS # |
2539-17-5
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| PubChem CID |
17343
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.6±0.1 g/cm3
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| Boiling Point |
316.0±37.0 °C at 760 mmHg
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| Melting Point |
119-121 °C (lit.)
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| Flash Point |
144.9±26.5 °C
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| Vapour Pressure |
0.0±0.7 mmHg at 25°C
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| Index of Refraction |
1.597
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| LogP |
4.6
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
13
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| Complexity |
180
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| Defined Atom Stereocenter Count |
0
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| SMILES |
ClC1C(Cl)=C(Cl)C(Cl)=C(OC)C=1O
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| InChi Key |
YZZVKLJKDFFSFL-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C7H4Cl4O2/c1-13-7-5(11)3(9)2(8)4(10)6(7)12/h12H,1H3
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| Chemical Name |
2,3,4,5-tetrachloro-6-methoxyphenol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.8180 mL | 19.0898 mL | 38.1796 mL | |
| 5 mM | 0.7636 mL | 3.8180 mL | 7.6359 mL | |
| 10 mM | 0.3818 mL | 1.9090 mL | 3.8180 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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