| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| Other Sizes |
| Targets |
Dimethylamine-d6 hydrochloride does not have a biological target as it is an analytical standard rather than a therapeutic agent. Dimethylamine hydrochloride (the non-deuterated form) is the immediate precursor of dimethylnitrosamine, a known potent carcinogen in a wide variety of animal species. The deuterated form serves as a stable isotope-labeled analog for analytical and research purposes.
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| ln Vitro |
In vitro, Dimethylamine-d6 hydrochloride is used as an internal standard for the quantification of dimethylamine in biological and environmental samples by LC-MS/MS or GC-MS. The compound is added to samples at a known concentration, and the ratio of labeled to unlabeled dimethylamine is measured to determine the concentration of the endogenous compound.
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| ln Vivo |
In vivo, Dimethylamine-d6 hydrochloride is not administered as a therapeutic agent. It is used in metabolic studies to trace the fate of dimethylamine in biological systems. The deuterated compound can be administered to animals to study the absorption, distribution, metabolism, and excretion of dimethylamine. However, such studies are specialized and not routine.
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| Enzyme Assay |
Non-cell-based assays for Dimethylamine-d6 hydrochloride involve analytical chemistry methods including LC-MS/MS and GC-MS for quantification. The compound serves as an internal standard for the measurement of dimethylamine and related metabolites. Its chemical properties (molecular weight 87.58, formula C₂H₂D₆ClN) are characterized. Its stability in biological samples is evaluated.
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| Cell Assay |
Cellular assays for Dimethylamine-d6 hydrochloride are not performed as the compound is an analytical standard. However, samples prepared using the compound as an internal standard may be used in metabolic studies of cell cultures. The compound itself does not have biological activity.
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| Animal Protocol |
In vivo experiments with Dimethylamine-d6 hydrochloride typically involve its use as a tracer or internal standard in metabolic studies. Animals are administered the deuterated compound, and plasma, urine, or tissue samples are collected. The compound and its metabolites are quantified by LC-MS/MS or GC-MS. The deuterium labeling allows for precise tracking of the compound's fate in the body.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties are not applicable to Dimethylamine-d6 hydrochloride as it is an analytical standard rather than a therapeutic agent. The compound is a stable isotope-labeled form of dimethylamine hydrochloride with identical chemical properties to the non-deuterated form. Its stability in biological samples and chromatographic behavior are characterized for analytical applications. No PK data are available.
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| Toxicity/Toxicokinetics |
The toxicity of Dimethylamine-d6 hydrochloride has not been evaluated as it is an analytical standard. Dimethylamine hydrochloride (the non-deuterated form) is the immediate precursor of dimethylnitrosamine, a known potent carcinogen. The deuterated form is expected to have similar properties but is handled with appropriate safety precautions. It is for research use only and is not intended for human consumption.
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| References | |
| Additional Infomation |
Dimethylamine-d6 hydrochloride (CAS# 53170-19-7) is a deuterium labeled form of dimethylamine hydrochloride with the molecular formula C₂H₂D₆ClN and a molecular weight of 87.58. It is also known as Dimethyl-d6 Amine Hydrochloride. The compound is a stable isotope-labeled internal standard used in analytical chemistry. Dimethylamine hydrochloride is the immediate precursor of dimethylnitrosamine, a known potent carcinogen. As of current knowledge, Dimethylamine-d6 hydrochloride is not approved as a therapeutic agent.
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| Molecular Formula |
C2H2D6CLN
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|---|---|
| Molecular Weight |
87.58
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| Exact Mass |
87.072
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| CAS # |
53170-19-7
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| PubChem CID |
12199012
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| Appearance |
White to off-white solid powder
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| Boiling Point |
47ºC at 760 mmHg
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| Melting Point |
170-173ºC(lit.)
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| LogP |
1.028
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
4
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| Complexity |
2.8
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| Defined Atom Stereocenter Count |
0
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| SMILES |
[2H]C([2H])([2H])NC([2H])([2H])[2H].Cl
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| InChi Key |
IQDGSYLLQPDQDV-TXHXQZCNSA-N
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| InChi Code |
InChI=1S/C2H7N.ClH/c1-3-2;/h3H,1-2H3;1H/i1D3,2D3;
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| Chemical Name |
1,1,1-trideuterio-N-(trideuteriomethyl)methanamine;hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 11.4181 mL | 57.0907 mL | 114.1813 mL | |
| 5 mM | 2.2836 mL | 11.4181 mL | 22.8363 mL | |
| 10 mM | 1.1418 mL | 5.7091 mL | 11.4181 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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