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| Targets |
3-Hydroxymorindone does not have a well-defined pharmacological target. As an anthraquinone compound, it may exert its biological effects through multiple mechanisms including antioxidant activity, modulation of cellular redox balance, and interaction with various enzymes and signaling pathways. Its potential antioxidative activity suggests that it may scavenge free radicals and reduce oxidative stress. The compound's pigment properties may also be relevant to its biological activities.
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| ln Vitro |
In vitro, 3-Hydroxymorindone may have antioxidative activity. As an anthraquinone, the compound may scavenge free radicals and reduce oxidative stress in cellular systems. Its pigment properties suggest potential interactions with cellular components. However, specific in vitro activity data for 3-Hydroxymorindone are limited. The compound is primarily characterized as a natural pigment and anthraquinone. Further studies are needed to fully characterize its biological activities.
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| ln Vivo |
In vivo, 3-Hydroxymorindone has not been extensively studied as a therapeutic agent. As a naturally occurring pigment found in Morinda citrifolia (Noni) and Pentas suswaensis, its presence in these plants may contribute to their traditional medicinal properties. However, specific in vivo data for 3-Hydroxymorindone are lacking. The compound is primarily used as a research tool for studying anthraquinone pigments and their biological activities.
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| Enzyme Assay |
Non-cell-based assays for 3-Hydroxymorindone involve characterization of its chemical properties and pigment characteristics. The compound's structure is confirmed by NMR and MS. Its purity is determined by HPLC. Antioxidant activity may be assessed by DPPH radical scavenging assays or ORAC assays. The compound's solubility and stability are characterized for research applications. Its pigment properties are characterized by UV-Vis spectroscopy.
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| Cell Assay |
Cellular assays for 3-Hydroxymorindone are performed using various cell lines including cancer cells and normal cells. Cells are treated with the compound at various concentrations, and cellular responses are measured. Cell viability is measured by MTT assays. Antioxidant activity is assessed by measuring intracellular ROS levels, glutathione levels, and antioxidant enzyme activities. The compound's effects on cellular signaling pathways may also be evaluated. However, specific data are limited.
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| Animal Protocol |
In vivo experiments with 3-Hydroxymorindone are limited as the compound is primarily used as a research tool. Animal studies may involve administration of the compound to evaluate its antioxidant or other biological effects. However, detailed in vivo data are not available. The compound is for research use only and is not intended for human consumption.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of 3-Hydroxymorindone have not been characterized. As an anthraquinone with a molecular weight of 286.24, the compound is expected to have moderate oral bioavailability. Its absorption, distribution, metabolism, and excretion are not defined. The compound's stability in biological matrices and its metabolic fate are not known. Comprehensive PK studies are lacking.
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| Toxicity/Toxicokinetics |
The toxicity profile of 3-Hydroxymorindone has not been comprehensively evaluated. As a naturally occurring anthraquinone pigment, the compound is generally considered to have low toxicity. However, some anthraquinones can be cytotoxic or genotoxic at high concentrations. Comprehensive toxicological studies including genotoxicity, organ toxicity, and maximum tolerated dose have not been fully characterized. The compound is for research use only.
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| References | |
| Additional Infomation |
3-hydroxymorinone has been reported to have been found in Pentas suswaensis and noni fruit, and relevant data are available for reference.
3-Hydroxymorindone (CAS# 80368-74-7) is an anthraquinone compound and pigment with the molecular formula C₁₅H₁₀O₆ and a molecular weight of 286.24. It is also known as 1,3,5,6-tetrahydroxy-2-methylanthracene-9,10-dione. 3-Hydroxymorindone is found in Morinda citrifolia (Noni) and Pentas suswaensis and may have antioxidative activity. As of current knowledge, 3-Hydroxymorindone is not approved as a therapeutic agent. |
| Molecular Formula |
C15H10O6
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|---|---|
| Molecular Weight |
286.24
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| Exact Mass |
286.047
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| CAS # |
80368-74-7
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| PubChem CID |
86012754
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.7±0.1 g/cm3
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| Boiling Point |
576.9±45.0 °C at 760 mmHg
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| Flash Point |
316.8±25.2 °C
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| Vapour Pressure |
0.0±1.7 mmHg at 25°C
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| Index of Refraction |
1.781
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| LogP |
5.15
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
21
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| Complexity |
463
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C1C2C(=CC(=C(C)C=2O)O)C(=O)C2C1=CC=C(C=2O)O
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| InChi Key |
JCZGUFVZKUDRMM-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C15H10O6/c1-5-9(17)4-7-11(12(5)18)13(19)6-2-3-8(16)15(21)10(6)14(7)20/h2-4,16-18,21H,1H3
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| Chemical Name |
1,3,5,6-tetrahydroxy-2-methylanthracene-9,10-dione
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4936 mL | 17.4679 mL | 34.9357 mL | |
| 5 mM | 0.6987 mL | 3.4936 mL | 6.9871 mL | |
| 10 mM | 0.3494 mL | 1.7468 mL | 3.4936 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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