| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
| Targets |
Bistrifluron targets the larval stage of insects, acting as a chitin synthesis inhibitor. It disrupts normal cuticle formation during molting, leading to larval mortality. It also affects adult longevity, reproduction, and hatchability.
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|---|---|
| ln Vitro |
Bistrifluron has insecticidal effects on larval stages, with activity against various lepidopteran pests including the cotton caterpillar Palpita indica. It reduces adult lifespan, impairs reproductive capacity, and decreases egg hatchability. Its effects are both immediate (larval mortality) and delayed (reproductive impact).
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| ln Vivo |
In vivo insecticidal activity has been demonstrated in pest control studies targeting Lepidoptera species. Efficacy is typically evaluated in laboratory and field settings by measuring larval mortality, pupation rates, adult emergence, and reproductive output.
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| Enzyme Assay |
Insecticide activity is assessed using standard insect bioassays. Larvae are exposed to treated diet or surfaces at various concentrations. Mortality is recorded at regular intervals, and LC50 values are calculated. Reproductive effects are evaluated by monitoring adult longevity, fecundity, and hatchability.
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| Cell Assay |
In vitro assays are not typically used for insecticide evaluation. Cell-based assays may involve insect cell lines to assess cytotoxicity or chitin synthesis inhibition, but standardized protocols for Bistrifluron are not well-documented in the literature.
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| Animal Protocol |
In vivo efficacy is evaluated using established insect pest models. Larvae are reared on artificial diet treated with Bistrifluron at defined concentrations. Mortality, development time, and adult reproductive parameters are recorded. Field trials may also be conducted.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for Bistrifluron are not extensively reported. The compound has solubility in DMSO at 250 mg/mL. As an agricultural insecticide, it is formulated for field application. Storage at -20°C is recommended.
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| Toxicity/Toxicokinetics |
Toxicological data indicate insecticidal activity primarily targeting chitin synthesis in insects. The compound has low mammalian toxicity but is designed to be effective against target pests. Handling precautions for agricultural chemicals apply.
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| References | |
| Additional Infomation |
Bistrifluron is an insecticide registered for agricultural use. It is not intended for human therapeutic applications. It is a member of the benzoylphenylurea class of insect growth regulators that interfere with chitin deposition.
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| Molecular Formula |
C16H7CLF8N2O2
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|---|---|
| Molecular Weight |
446.68
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| Exact Mass |
446.007
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| CAS # |
201593-84-2
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| PubChem CID |
10275455
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| Appearance |
White to off-white solid powder
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| Density |
1.606g/cm3
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| Melting Point |
172 - 175°C (lit.)
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| Index of Refraction |
1.515
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| LogP |
6.206
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
10
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
29
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| Complexity |
605
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
YNKFZRGTXAPYFD-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H7ClF8N2O2/c17-12-7(16(23,24)25)4-6(15(20,21)22)5-10(12)26-14(29)27-13(28)11-8(18)2-1-3-9(11)19/h1-5H,(H2,26,27,28,29)
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| Chemical Name |
N-[[2-chloro-3,5-bis(trifluoromethyl)phenyl]carbamoyl]-2,6-difluorobenzamide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 250 mg/mL (559.68 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2387 mL | 11.1937 mL | 22.3874 mL | |
| 5 mM | 0.4477 mL | 2.2387 mL | 4.4775 mL | |
| 10 mM | 0.2239 mL | 1.1194 mL | 2.2387 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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