| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 500mg |
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| 1g |
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| Other Sizes |
| Targets |
Naphthalene-d8 does not have specific pharmacological targets as it is primarily used as a stable isotope-labeled compound for analytical and research applications. It is used as a solvent in NMR spectroscopy of aromatic compounds and in OLED applications. As a deuterated compound, it may be used to study the effects of deuteration on pharmacokinetics and metabolic properties of drugs. However, it is not used as a therapeutic agent.
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| ln Vitro |
Drug compounds have included stable heavy isotopes of carbon, hydrogen, and other elements, mostly as quantitative tracers while the drugs were being developed. Because deuteration may have an effect on a drug's pharmacokinetics and metabolic properties, it is a cause for concern [1].
In vitro, Naphthalene-d8 is not evaluated for traditional biological activity as it is an analytical reference standard and deuterated solvent. It is used in NMR spectroscopy as a solvent for studying aromatic compounds. The compound's deuterium labeling makes it useful for tracing studies and mechanistic investigations in chemistry. It is also used in OLED applications and as a quantitative tracer in pharmaceutical development. |
| ln Vivo |
In vivo activity data for Naphthalene-d8 are not applicable as the compound is used as an analytical standard and deuterated solvent rather than a therapeutic agent. The compound is not administered to animals for pharmacological evaluation. Its applications are limited to analytical and research settings, including NMR spectroscopy and quality control.
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| Enzyme Assay |
Naphthalene-d8 is not evaluated in traditional enzyme/receptor binding assays. However, it is used as a solvent and internal standard in NMR spectroscopy for structural elucidation of organic compounds. The compound can be analyzed by GC or GC-MS for purity assessment and analytical applications. Its deuterium content and isotopic purity are important quality parameters for its use as a labeled compound.
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| Cell Assay |
Naphthalene-d8 is not evaluated in traditional cellular assays as it is used primarily as an analytical standard and NMR solvent. However, it may be used in cell culture studies as a solvent for hydrophobic compounds or as an internal standard for analytical quantification. The compound is a solvent and should be handled with appropriate safety precautions.
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| Animal Protocol |
Naphthalene-d8 is not used in in vivo animal experiments as it is primarily an analytical standard and NMR solvent. The compound is not administered to animals for pharmacological evaluation. Its applications are limited to laboratory research settings including NMR spectroscopy and quality control.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Naphthalene-d8 would be similar to those of naphthalene, with the deuterium substitution potentially affecting metabolic stability. The compound has a molecular weight of 136.22 g/mol and molecular formula C₁₀D₈. As a lipophilic aromatic hydrocarbon, it is expected to have good membrane permeability and tissue distribution. The compound is used as a solvent and should be handled with appropriate safety precautions.
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| Toxicity/Toxicokinetics |
The toxicological profile of Naphthalene-d8 is expected to be similar to that of naphthalene, a polycyclic aromatic hydrocarbon. Naphthalene can be toxic at high doses and is classified as a potential carcinogen. The deuterated analog may have altered metabolic stability and toxicity due to the isotope effect. Comprehensive toxicological evaluations have not been reported. Standard laboratory safety precautions should be followed.
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| References | |
| Additional Infomation |
Naphthalene-d8 (CAS# 1146-65-2, molecular formula C₁₀D₈, molecular weight 136.22) is the fully deuterated isotopologue of naphthalene. It is used as a solvent in NMR spectroscopy, in OLED applications, and as a quantitative tracer in pharmaceutical development. Also known as perdeuteronaphthalene and octadeuteronaphthalene. No clinical trials or regulatory approvals have been identified.
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| Molecular Formula |
C10D8
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|---|---|
| Molecular Weight |
136.22
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| Exact Mass |
136.112
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| CAS # |
1146-65-2
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| Related CAS # |
Naphthalene-13C10;219526-41-7;Naphthalene-sup>13C6;1192501-11-3
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| PubChem CID |
92148
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| Appearance |
White to off-white solid powder
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
221.5±7.0 °C at 760 mmHg
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| Melting Point |
80-82ºC(lit.)
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| Flash Point |
78.9±0.0 °C
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| Vapour Pressure |
0.2±0.2 mmHg at 25°C
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| Index of Refraction |
1.632
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| LogP |
3.45
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
0
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
10
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| Complexity |
80.6
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| Defined Atom Stereocenter Count |
0
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| SMILES |
[2H]C1=C(C(=C2C(=C(C(=C(C2=C1[2H])[2H])[2H])[2H])[2H])[2H])[2H]
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| InChi Key |
UFWIBTONFRDIAS-PGRXLJNUSA-N
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| InChi Code |
InChI=1S/C10H8/c1-2-6-10-8-4-3-7-9(10)5-1/h1-8H/i1D,2D,3D,4D,5D,6D,7D,8D
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| Chemical Name |
1,2,3,4,5,6,7,8-octadeuterionaphthalene
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.3411 mL | 36.7053 mL | 73.4107 mL | |
| 5 mM | 1.4682 mL | 7.3411 mL | 14.6821 mL | |
| 10 mM | 0.7341 mL | 3.6705 mL | 7.3411 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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