| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
|
||
| Other Sizes |
| Targets |
Specific molecular targets of 1-Methoxyindole-3-carboxylic acid have not been extensively characterized. As a natural indole alkaloid from Isatis species, it may share biological activities with other indole compounds, including antimicrobial, anti-inflammatory, or antioxidant properties. Indole-3-carboxylic acid derivatives are known for various biological activities. However, specific molecular targets for 1-Methoxyindole-3-carboxylic acid have not been identified in the available literature.
|
|---|---|
| ln Vitro |
In vitro activity data for 1-Methoxyindole-3-carboxylic acid are limited in the published literature. The compound has been primarily characterized as a natural product from Isatis species. As an indole alkaloid, it may exhibit various biological activities including antimicrobial, anti-inflammatory, or antioxidant effects in cell-based assays. However, detailed in vitro activity data including IC₅₀ values have not been extensively published. The compound can be used as a reference standard.
|
| ln Vivo |
In vivo activity data for 1-Methoxyindole-3-carboxylic acid are not available in the published literature. The compound has been primarily characterized as a natural product from Isatis species. No in vivo pharmacological studies have been reported for this compound. Given its presence in Isatis, a plant used in traditional medicine, it may contribute to the therapeutic effects of the plant. However, dedicated in vivo studies for this compound have not been conducted or reported.
|
| Enzyme Assay |
In vitro assays for 1-Methoxyindole-3-carboxylic acid are not extensively documented. As an indole alkaloid, potential assays could include antimicrobial activity evaluation using broth microdilution or disc diffusion methods, antioxidant activity using DPPH or ABTS radical scavenging assays, or anti-inflammatory activity by measuring cytokine production in immune cells. The compound's structure can be confirmed by NMR and MS. Purity is ≥98%. The compound is soluble in DMSO.
|
| Cell Assay |
In vitro cellular assays for 1-Methoxyindole-3-carboxylic acid are not extensively documented. Potential cellular assays could include evaluation of antimicrobial activity in bacterial or fungal culture systems, anti-inflammatory activity in immune cells, or antioxidant effects in cell-based oxidative stress models. Cells are treated with the compound and cell viability, cytokine production, or other readouts are measured. The compound is typically handled as a solid and is soluble in DMSO for cell culture applications.
|
| Animal Protocol |
In vivo animal experiments for 1-Methoxyindole-3-carboxylic acid have not been reported in the published literature. The compound has been studied primarily as a natural product from Isatis species. No animal studies have been conducted to evaluate its pharmacological effects, toxicity, or pharmacokinetics. Further research would be required to investigate its potential therapeutic applications in vivo.
|
| ADME/Pharmacokinetics |
Pharmacokinetic properties of 1-Methoxyindole-3-carboxylic acid have not been characterized. The compound has a molecular weight of 191.2 g/mol and a molecular formula of C₁₀H₉NO₃. As a small, moderately lipophilic indole carboxylic acid, it is expected to have reasonable membrane permeability and oral bioavailability. The compound is a natural product of Isatis, Brassicaceae. Storage: desiccated at -20°C. Purity ≥98%.
|
| Toxicity/Toxicokinetics |
The toxicological profile of 1-Methoxyindole-3-carboxylic acid has not been extensively documented. As a natural indole alkaloid from Isatis species, it is expected to have a relatively favorable safety profile. However, comprehensive toxicological evaluations including acute toxicity, genotoxicity, and repeated-dose studies have not been reported. Standard laboratory safety precautions should be followed when handling this compound.
|
| References | |
| Additional Infomation |
There have been reports of 1-methoxyindole-3-carboxylic acid being found in Arabidopsis thaliana and Acacia japonica, and relevant data are available for reference.
1-Methoxyindole-3-carboxylic acid (CAS# 91913-76-7, molecular formula C₁₀H₉NO₃, molecular weight 191.2) is a natural indole alkaloid from Isatis, Brassicaceae. Also known as 1H-Indole-3-carboxylic acid, 1-methoxy-. Can be used as a reference standard. No clinical trials or regulatory approvals have been identified. Purity ≥98%. Storage: desiccated at -20°C. |
| Molecular Formula |
C10H9NO3
|
|---|---|
| Molecular Weight |
191.18
|
| Exact Mass |
191.058
|
| CAS # |
91913-76-7
|
| PubChem CID |
124476
|
| Appearance |
Typically exists as solid at room temperature
|
| Density |
1.3±0.1 g/cm3
|
| Boiling Point |
382.0±34.0 °C at 760 mmHg
|
| Flash Point |
184.8±25.7 °C
|
| Vapour Pressure |
0.0±0.9 mmHg at 25°C
|
| Index of Refraction |
1.599
|
| Source |
Originated from plants: Brassicaceae Isatis tinctoria L.
Originated from plants: Cruciferae Isatis tinctoria L. |
| LogP |
2.69
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
14
|
| Complexity |
231
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O=C(C1C2C(=CC=CC=2)N(OC)C=1)O
|
| InChi Key |
NYXZLEZAQMDQPX-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C10H9NO3/c1-14-11-6-8(10(12)13)7-4-2-3-5-9(7)11/h2-6H,1H3,(H,12,13)
|
| Chemical Name |
1-methoxyindole-3-carboxylic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.2307 mL | 26.1534 mL | 52.3067 mL | |
| 5 mM | 1.0461 mL | 5.2307 mL | 10.4613 mL | |
| 10 mM | 0.5231 mL | 2.6153 mL | 5.2307 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
